Oral Modified Drug Release Solid Dosage Form with Special Reference to Design; An Overview

Abstract

Oral drug delivery is the most widely utilized route of administration among all the routes that have been explored for systemic delivery of drugs via pharmaceutical products of different dosage form and this oral route provides maximum active surface area among all drug delivery system for administration of various drugs. The attractiveness of these dosage forms is due to awareness of toxicity and ineffectiveness of drugs when administered by oral conventional method in the form of tablets and capsules. Usually, conventional dosage form produces wide range of fluctuation in drug concentration in the bloodstream and tissues with consequent undesirable toxicity and poor efficiency. The maintenance of concentration of drug in plasma within therapeutic index is very critical for effective treatment. These factors as well as factors such as repetitive dosing and unpredictable absorption lead to the concept of oral modified drug delivery systems like Sustained release, prolonged release, modified release, extended release. These formulations are used to identify drug delivery systems that are designed to achieve or extend therapeutic effect by continuously releasing medication over an extended period of time after administration of a single dose. This review describes the basic information regarding modified release dosage form like designed to release their medication in controlled manner, criteria for selecting modified release dosage form and factors influencing the dosage and release pattern.

Evaluation of Community Pharmacists Knowledge, Attitude and Practice towards Modified Release Dosage Forms

“…There were 175 responses from participants to the questionnaire. The demographic data of the questionnaire participants are shown in Table (1). The Cronbach Alpha coefficient was used where its value was (0.67).…”

“…Modified release dosage forms can be defined as drug products that alter the timing and/or the release pattern of the active drug substance (1) . They come into different classes including extended release, delayed release, repeated action and targeted release dosage forms (2) .…”

Polymeric Nanofibers for Drug Delivery Applications: A Recent Review

“…Oral administration is currently the clinically main technique of administration, with oral pharmaceuticals accounting for more than half of all FDA-approved drugs [ 95 ]. The medicine is absorbed into the body through the digestive system, disseminated into the blood circulation by the drug molecule, and carried to the target tissue/organ to exert its medical action following oral delivery [ 96 ]. Oral administration contains the advantages of low price, convenience, easy and stable transportation, portability, and no direct damage to the skin.…”

Influence of Prunus domestica gum on the release profiles of propranolol HCl floating tablets

“…Bulk and Tapped densities ranged from 0.43 to 0.46 g/cm 3 and 0.50 to 0.53 g/cm 3 respectively. These values are closer to each other which indicates non-significant inter-particulate interactions among the formulations excipients good packing characteristics, important for storage, flow and compaction of the powder during manufacturing [34].…”

“…But these demerits can be surpassed by developing a controlled-release oral delivery system. The system is considered advantageous over conventional oral dosage forms in terms of producing a uniform and prolonged drug release, decreasing the frequency of drug dosing and reducing variation in the therapeutic index [2][3][4]. Besides the advantages, variations in gastrointestinal transit (GT) and gastric residence time (GRT) have been observed with the controlled drug therapy due to the physiological variabilities among the individuals.…”