Oral manifestations of graft-versus-host disease in patients submitted to allogeneic hematopoietic stem cell transplantation: the experience of a Brazilian Cancer Center

Scaraficci, Ana Claúdia; Fernandes, Patrícia Maria; Alves, Fábio Abreu; Filho, Jayr Schmidt; Jaguar, Graziella Chagas

doi:10.1007/s00520-021-06349-9

Cited by 2 publications

(1 citation statement)

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“…We also found that the site most affected by oral mucosal disease of cGVHD was the buccal mucosa, which is similar to that of a prior study by Scaraficci AC et al . ( 12 ). Moreover, we found the most severely affected site that presented with ulcerative lesions was also the buccal mucosa, followed by the ventral tongue.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of oral chronic graft-versus-host disease according to the 2014 National Institutes of Health (USA) consensus criteria

Pengpis

Prueksrisakul²,

Chanswangphuwana³

2023

Med Oral

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Background Chronic graft-versus-host disease (cGVHD) is a serious and common complication of allogeneic hematopoietic cell transplantation (alloHCT). The oral cavity is the second most common site affected by cGVHD. In 2014, the 2005 National Institutes of Health (NIH) consensus criteria were revised to address areas of controversy. The aim of this study was to evaluate the clinical characteristics of oral cGVHD using the 2014 NIH consensus criteria. Material and Methods The baseline data of oral manifestation of patients, who were diagnosed with oral cGVHD, in the first dental visit were analyzed (n=22). The oral mucosal disease was evaluated by NIH modified Oral Mucosa Rating Scale (OMRS) and Thongprasom sign score. The salivary gland disease and sclerotic disease were determined by the presence of signs and symptoms. The functional impact was assessed by the organ-specific severity score. Results The median time from transplant to oral cGVHD diagnosis was 11.9 months. White striae with an erosive area was found in 72.7% of the patients. The mean ± SD of NIH modified OMRS was 6.1 ± 3.0. The most common and severely affected site of lichen planus-like features was buccal mucosa. Xerostomia, superficial mucocele and limited mouth opening were found in 18.2%, 9.1%, and 9.1%, respectively, of the patients. Almost all patients (90.9%) had partial limitation of oral intake. There were no significant differences in NIH modified OMRS or organ-specific severity score among the patient characteristic groups. Moreover, there was no association between the oral manifestations of cGVHD and the patient characteristics. Conclusions The most common oral manifestation of cGVHD was white striae with an erosive area of oral mucosal disease, followed by xerostomia, superficial mucocele, and limited mouth opening. The 2014 NIH consensus criteria for diagnostic and severity assessment are informative and feasible in real-world practice. Key words: Oral chronic graft-versus-host disease, 2014 National Institutes of Health consensus criteria, oral mucosal disease, hematopoietic cell transplantation.

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Section: Discussionmentioning

confidence: 99%