Oral Manifestations of Exudative Erythema Multiforme in a Patient with COVID-19

Dalipi, Zana Sllamniku; Dragidella, Fatmir; Dragidella, Donika

doi:10.1155/2021/1148945

Cited by 14 publications

(30 citation statements)

References 22 publications

(19 reference statements)

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“…The use of drugs for the treatment of some oral lesions has been reported, including topical agents such as 2% chlorhexidine for lacerations, hyaluronic acid, tranexamic acid for local bleeding, and miconazole for patients with a cytological diagnosis of candidiasis [ 57 ]. Cases have been described of patients with erythema multiforme-like lesions using topical antiseptic medications of 0.2% chlorhexidine solution, in addition to the prescription of vitamin C, B complex, systemic corticosteroids, and panthenol-calcium with pantothenic acid (locally applied tablets); promotion of healing of the labial mucosa in these patients was performed with the typical application of Vaseline [ 48 , 140 ].…”

Section: Pharmacological Therapy For the Treatment Of Oral Lesions In...mentioning

confidence: 99%

Oral Lesions Associated with COVID-19 and the Participation of the Buccal Cavity as a Key Player for Establishment of Immunity against SARS-CoV-2

Gutiérrez-Camacho

Ávila-Carrasco

Martinez-Vazquez

et al. 2022

IJERPH

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Background: Some oral lesions have been described in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); the possibility has been raised that the buccal lesions observed in patients with the coronavirus disease 2019 (COVID-19) are due to this virus and the patient’s systemic condition. The aim of this review was to integrate the knowledge related to the oral lesions associated with COVID-19 and the participation of the buccal cavity in the establishment of immunity against SARS-CoV-2. Methods: A literature search on the manifestations of buccal lesions from the beginning of the pandemic until October 2021 was carried out by using the PubMed database. A total of 157 scientific articles were selected from the library, which included case reports and reports of lesions appearing in patients with COVID-19. Results: Oral lesions included erosions, ulcers, vesicles, pustules, plaques, depapillated tongue, and pigmentations, among others. The oral cavity is a conducive environment for the interaction of SARS-CoV-2 with the mucosal immune system and target cells; direct effects of the virus in this cavity worsen the antiviral inflammatory response of underlying oral disorders, immunodeficiencies, and autoimmunity primarily. Conclusions: The oral cavity is an accessible and privileged environment for the interaction of SARS-CoV-2 with the mucosal immune system and target cells; the direct effects of the virus in this cavity worsen the antiviral inflammatory response of underlying oral disorders, in particular those related to immunodeficiencies and autoimmunity.

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Section: Pharmacological Therapy For the Treatment Of Oral Lesions In...mentioning

confidence: 99%

Oral Lesions Associated with COVID-19 and the Participation of the Buccal Cavity as a Key Player for Establishment of Immunity against SARS-CoV-2

Gutiérrez-Camacho

Ávila-Carrasco

Martinez-Vazquez

et al. 2022

IJERPH

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“…Such findings agree with the presented case report. About the cutaneous manifestations in patients with COVID-19 infection, several syndromes were related to it [11,12]. Among these, EM lesions are of great importance [12,13].…”

Section: Discussionmentioning

confidence: 99%

“…About the cutaneous manifestations in patients with COVID-19 infection, several syndromes were related to it [11,12]. Among these, EM lesions are of great importance [12,13]. EM is an acute, immune-mediated disease appearing with typical 'target' lesions [13].…”

Section: Discussionmentioning

confidence: 99%

Erythema Multiforme as Early Manifestation of COVID-19: A Case Report

et al. 2022

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Background: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a viral infection involving multi-organ manifestations. The main oral symptoms of COVID-19 associated are taste loss and xerostomia, but literature has reported other oral manifestation, such as oral blisters, ulcers, vesicles and other immunological lesions. This case report showed an Erythema Multiforme (EM) manifesting as oral mucosa lesions in a patient with a late diagnosis of COVID-19 infection. Case Presentation: A 30 years-old Caucasian woman was sent to an oral medicine office, in order to manage painful and oral mucosa lesions associated with target symmetrical skin lesions. Oral examination revealed extensive ulcers in the mouth and crusts on the lips. Based on clinical examinations, a diagnosis of Erythema Multiforme major was made and a drug therapy with steroids was administered. Five days after the specialist visit, the patient discovered that she was positive for COVID-19. The complete recovery occurred in 3 weeks. Conclusion: Confirming the literature studies, EM is an early disease associated with COVID-19 infection.

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“…Coronavirus disease 2019 (COVID‐19), caused by a single‐chain RNA virus, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has resulted in global healthcare crisis, with grave health and socioeconomic impact. 1 , 2 The worst affected countries included United States, India and Brazil, as more than 50% of all the cases were reported from these nations. 3 The primary manifestations of COVID‐19 include pneumonia and acute respiratory distress syndrome, although many organ systems have been affected including the gastrointestinal tract, liver, central nervous systems, blood vessels, heart and kidneys.…”

Section: Introductionmentioning

confidence: 99%

“…The most commonly reported manifestations include symptoms common to other viral infections such as fever, cough, sore throat, myalgia, arthralgia, headache, dyspnoea, and excessive sputum production. However, an increasing number of atypical clinical presentations have been reported, such as gastrointestinal symptoms like anorexia, tremors, nausea, vomiting, and diarrhoea, 1 dermatological manifestations, and chemosensory dysfunctions. 2 COVID‐19 also causes direct injury to myocardial cells mediated by angiotensin‐converting enzyme 2 (ACE2) receptors and additionally by systemic inflammation causing indirect myocyte injury.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of oral manifestations in COVID‐19: A systematic review

Sharma

Malik

Wadhwan

et al. 2022

Reviews in Medical Virology

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Coronavirus disease 2019 (COVID‐19) is a novel disease caused by a newly identified virus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) causing diverse systemic manifestations. The oral cavity too is not spared and the symptoms appear either independently, concurrently, or sequentially. In view of the rising documented cases of oral lesions of COVID‐19, this systematic review aims to assess the prevalence of oral manifestations in COVID‐19 confirmed individuals. An extensive literature search was conducted in databases like Scopus, Pubmed/Medline, Livivo, Lilacs and Google Scholar and varied oral signs and symptoms were reported as per the PRISMA guidelines. Studies published in English language literature only were included and were subjected to the risk of bias using the Joana Briggs Institute Appraisal tools for prevalence studies, case series and case reports. In a two‐phase selection, 34 studies were included: 21 observational, 3 case‐series and 10 case reports. These observational studies included approximately 14,003 patients from 10 countries. In this review, we explored the most commonly encountered oral and dental manifestations in COVID‐19 and identified that loss of taste acuity, xerostomia and anosmia were frequently reported. Elevated incidence of opportunistic infections like mucormycosis and aspergillosis were reported during the treatment due to prolonged intake of steroids. Immunosuppression and poor oral hygiene led to secondary manifestations like enanthematous lesions. However, it is not clear that oral signs and symptoms are due to COVID‐19 infection itself or are the result of extensive treatment regimen followed [PROSPERO CRD42021258264].

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Oral Manifestations of Exudative Erythema Multiforme in a Patient with COVID-19

Cited by 14 publications

References 22 publications

Oral Lesions Associated with COVID-19 and the Participation of the Buccal Cavity as a Key Player for Establishment of Immunity against SARS-CoV-2

Oral Lesions Associated with COVID-19 and the Participation of the Buccal Cavity as a Key Player for Establishment of Immunity against SARS-CoV-2

Erythema Multiforme as Early Manifestation of COVID-19: A Case Report

Prevalence of oral manifestations in COVID‐19: A systematic review

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