Oral lichen planus: A benign lesion

Suitability/Unsuitability of Cell Proliferation as an Indicator of Malignant Potential in Oral Lichen Planus: an Immunohistochemical Study

“…Histopathological diagnostic criteria described by Eisenberg, (2000) were used for oral lichen planus diagnosis. Any case exposed to risk factors of oral cancer such as smoking/drinking behaviors were excluded.…”

Estudo comparativo das alterações celulares no líquen plano e no carcinoma epidermóide bucal

“…[1][2][3][4][5] Some authors, however, believe that malignant transformation has not been sufficiently documented to justify the classification of OLP as a precancerous lesion, as proposed by the WHO.6 For these authors, both clinical and histopathological criteria for diagnosing OLP with greater precision are lacking; this situation questions the cases of malignant transformation of OLP reported in the literature. [7][8] Our study revealed that cell alterations, such as an increased nucleus/cytoplasm ratio, irregular distribution of chromatin, thickening of the nuclear membrane, loss of cell adhesion, increased size and number of nucleoli, and bi-or multinucleation may be seen both in OLP and in the epidermoid carcinoma. This is probably because some of the inflammatory features are similar to those seen in malignancies, particularly those that indicate increased proliferation due to the many growth factors released to epithelial cells in chronic inflammation.…”

“…Most of the cases of malignant transformation would thus not be considered as such, since in these cases there probably were histopathological signs suggesting a malignancy at the moment of the initial diagnosis, which would void the hypothesis of OLP. [7][8] Van der Meij and Van der Waal 9 (2003) illustrated this difficulty in the diagnosis of OLP. These authors found that there was no consensus in the histopathological diagnosis of 42% of cases in which the clinical diagnosis was clear.…”

Expressão imuno-histoquímica de Bcl-2, Ki-67 e caspase-3 ativa em líquen plano oral e leucoplasia com diferentes graus de displasia

“…Os achados histopatológicos do LPO incluem liquefação da camada basal acompanhada por intenso infiltrado inflamatório disposto em banda, subjacente ao epitélio, composto principalmente de linfócitos T e histiócitos; presença de numerosos corpúsculos colóides eosinofílicos na interface epitélio-conjuntivo (corpos de Civatte); cristas epiteliais interpapilares ausentes, hiperplásicas ou, frequentemente, projetadas em "dentes de serra"; variações da espessura da camada espinhosa e graus variados de orto ou paraqueratose (EISENBERG, 2000;REGEZI et al, 2000;EDWARDS et al, 2002;NEVILLE et al, 2004).…”

“…Contudo, muitos autores acreditam que não haja dados suficientes que provem uma associação entre líquen plano e câncer (SOUSA et al, 2009). Para esses autores, a maioria dos casos que sofreram transformação maligna é decorrente de falhas no diagnóstico inicial da lesão, que se baseia na presença de uma banda de infiltração de linfócitos T na interface epitélio-tecido conjuntivo (EISENBERG, 2000). Por outro lado, o potencial de algumas lesões de LPO para transformação maligna é atualmente reconhecido, embora sua etiologia e patogênese não sejam bem elucidadas (KÜFFER et al, 2002).…”