Oral leukoplakia and the long‐term risk of upper gastrointestinal cancer deaths in the Linxian dysplasia population

Yang, Huan; Zhang, Su; Wang, Jianbing; Fan, Jin‐Hu; Qiao, You‐Lin; Taylor, Philip R.

doi:10.1111/1759-7714.13595

Cited by 5 publications

(4 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thirdly, socioeconomic status (SES) is a major confounder and a powerful determinant of common chronic diseases. Despite we included education level as a surrogate factor of SES according to the previous study, [ 44 ] the confounding bias caused by missing SES information needs to be acknowledged. Finally, other baseline information was collected by questionnaire, which may lead to a limited extrapolation of our study.…”

Section: Discussionmentioning

confidence: 99%

Weight change and all-cause and cause-specific mortality: A 25-year follow-up study

Yang,

Wang,

Wang

et al. 2024

Chinese Medical Journal

Self Cite

View full text Add to dashboard Cite

Background: Whether the dynamic weight change is an independent risk factor for mortality remains controversial. This study aimed to examine the association between weight change and risk of all-cause and cause-specific mortality based on the Linxian Nutrition Intervention Trial (NIT) cohort. Methods: Body weight of 21,028 healthy residents of Linxian, Henan province, aged 40–69 years was measured two times from 1986 to 1991. Outcome events were prospectively collected up to 2016. Weight maintenance group (weight change <2 kg) or stable normal weight group was treated as the reference. Cox proportional hazard model was performed to calculate hazard ratios (HRs) and 95% confidence intervals (95% CIs) to estimate the risk of mortality. Results: A total of 21,028 subjects were included in the final analysis. Compared with the weight maintenance group, subjects with weight loss ≥2 kg had an increased risk of death from all-cause (HRAll-cause = 1.14, 95% CI: 1.09–1.19, P <0.001), cancer (HRCancer = 1.12, 95% CI: 1.03–1.21, P = 0.009), and heart disease (HRHeart diseases = 1.21, 95% CI: 1.11–1.31, P <0.001), whereas subjects with weight gain ≥5 kg had 11% (HRCancer = 0.89, 95% CI: 0.79–0.99, P = 0.033) lower risk of cancer mortality and 23% higher risk of stroke mortality (HRStroke=1.23,95% CI: 1.12–1.34). For the change of weight status, both going from overweight to normal weight and becoming underweight within 5 years could increase the risk of total death (HROverweight to normal = 1.18, 95% CI: 1.09–1.27; HRBecoming underweight = 1.35, 95% CI: 1.25–1.46) and cancer death (HROverweight to normal = 1.20, 95% CI: 1.04–1.39; HRBecoming underweight = 1.44, 95% CI: 1.24–1.67), while stable overweight could increase the risk of total death (HRStable overweight = 1.11, 95% CI: 1.05–1.17) and death from stroke (HRStable overweight = 1.44, 95% CI: 1.33–1.56). Interaction effects were observed between age and weight change on cancer mortality, as well as between baseline BMI and weight change on all-cause, heart disease, and stroke mortality (all P interaction <0.01). Conclusions: Weight loss was associated with an increased risk of all-cause, cancer, and heart disease mortality, whereas excessive weight gain and stable overweight were associated with a higher risk of stroke mortality. Efforts of weight management should be taken to improve health status. Trial registration: NCT00342654, https://classic.clinicaltrials.gov/.

show abstract

Section: Discussionmentioning

confidence: 99%

Weight change and all-cause and cause-specific mortality: A 25-year follow-up study

Yang,

Wang,

Wang

et al. 2024

Chinese Medical Journal

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, research on the relationship between risk factors and UGI cancer in the dysplasia population is limited. Some studies have suggested that body mass index, oral leukoplakia, and tooth loss increase the risk of death from UGI cancer in this population ( 6 , 19 , 22 ). However, no study suggests the association between family history of UGI cancer and the risk of its death.…”

Section: Introductionmentioning

confidence: 99%

“…Through the comparison of the general group and dysplasia group in the Linxian Nutrition Intervention Trial, we found differences of age, body mass index, alcohol consumption, and fresh vegetable intake between the two groups ( 8 , 17 , 18 ). By comparing the incidence and death of cancers in these two groups, with 30 years of follow-up, it was found that esophageal cancer death in the general population accounted for 44.47% of the total death of malignant cancers and the death of gastric cancer accounted for 33.48%, while in high-risk groups, esophageal cancer and gastric cancer accounted for 51.2% and 34.0%, respectively ( 6 , 19 ). At present, studies on the relationship between risk factors and UGI cancer in the general population have provided reliable and sufficient information ( 8 , 20 , 21 ).…”

Section: Introductionmentioning

confidence: 99%

The Association Between Family History of Upper Gastrointestinal Cancer and the Risk of Death from Upper Gastrointestinal Cancer–based on Linxian Dysplasia Nutrition Intervention Trial (NIT) Cohort

Sun

Yang²,

Wang³

et al. 2022

Front. Oncol.

Self Cite

View full text Add to dashboard Cite

ObjectiveExplore the influence of family history of upper gastrointestinal (UGI) cancer on UGI cancer death, based on the Linxian Dysplasia Nutrition Intervention Trial (NIT) cohort.MethodsFamily history of UGI cancer was defined as at least one first-degree relative (parent, child, or sibling) had a history of esophageal or gastric cancer. Cancer death was carried out by ICD-10 code. Family history information was collected at baseline and cancer deaths were assessed at each annual follow-up. The COX proportional risk model was used to estimate the hazard ratio (HR) and 95% confidence interval (95% CI). We compared the positive family history group with the negative to determine the risk of family history on UGI cancer death. The effect of category of relatives, number of relatives with UGI cancer, and diagnosis age of relatives on the UGI death risk were further analyzed. Interaction and stratification analyses were done to see the subgroup effects. Sensitivity analyses were also conducted by exclusion of individuals who were followed up less than three years. We considered controlling of covariates including: gender, age (continuity), community, education level, number of siblings (continuity), BMI (continuity), smoking, alcohol use, fresh fruit intake, fresh vegetable intake, hot beverage intake, edible oil intake, meat intake, and moldy staple food intake. All food intake variables were converted into categorical variables.ResultsFrom1985 to2015, we followed up total 3,318 individuals with 898 UGI cancer deaths (537 from ESCC, 77 from GNCC, and 284 from GCC). In a single factor analysis, family history of UGI cancer increased the risk of death of esophageal squamous cell carcinoma (ESCC) by 27% (HR=1.270, 95%CI1.072-1.504). No associations were observed in gastric cardia carcinoma (GCC) and gastric non-cardia carcinoma (GNCC). After adjusting for multi-factor, a family history of UGI cancer risk of death increased by 31.9% from ESCC (HR=1.319,95%CI:1.110-1.567). Subgroup analysis of different types of relatives with UGI cancers, UGI cancers in the mother (HR=1.457,95%CI:1.200-1.768), brother (HR=1.522,95%CI:1.117-2.073), and sister (HR=1.999,95%CI:1.419-2.817) were independent risk factors for ESCC death, while the father was not. In addition, 2 relatives with UGI cancer (HR=1.495, 95%, CI:1.110-2.013) and ≥3 relatives with UGI cancer (HR=2.836, 95%CI:1.842-4.367) significantly increased the risk of ESCC death, and the trend test was statistically significant (P<0.001). Relatives’ diagnostic age of 51-60 years (HR=1.322, 95%CI:1.046-1.672) and 41-50 years (HR=1.442, 95%CI:1.078-1.930) were the risk factors for ESCC death, with statistical significance in the trend test (P=0.010). No statistically significant result of the family history effect on the risk of death from GCC or GNCC was found. Sensitivity analysis of 80% of subjects, randomly selected, did not change the results.ConclusionA family history of UGI cancer may predict the risk of death from ESCC but not from GCC or GNCC. UGI cancer in the mother may predict the risk of death from ESCC, but not father, which indicates gender differences. Gender and smoking are the interaction items with family history in a similar extent. In the subgroup, the risk of ESCC death is more distinct by family history in younger, female, and better-lifestyle individuals, which indicates the unique role of genetic factors.

show abstract

“…High concentrations of nitrate and nitrite in water are a common characteristic among most countries with a high GC incidence, such as Chile, Costa Rica, and Japan [ 17 ]. Linxian, a rural county of Anyang, Henan Province, is one of the high-incidence regions of upper gastrointestinal (UGI) cancer in China [ 18 ]. The region's arid climate and low annual rainfall make surface water, such as mountain spring water and shallow well water, the primary water resource [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Association between type of drinking water and upper gastrointestinal cancer incidence in the Linxian General Population

Yang

Wang

et al. 2023

BMC Cancer

Self Cite

View full text Add to dashboard Cite

Background This study aimed to explore the association between drinking water source and risk of upper gastrointestinal (UGI) cancer, including esophageal cancer (EC) and gastric cancer (GC), in the Linxian General Population Nutrition Intervention Trial (NIT) cohort. Methods In this study, we used data from the Linxian NIT cohort, which included 29,584 healthy adults aged 40 to 69 years. Subjects were enrolled in April 1986 and followed up until March 2016. Tap water drinking status and demographic characteristics were collected at baseline. Subjects who drank tap water were treated as the exposed group. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were estimated using the Cox proportional hazard model. Results A total of 5,463 cases of UGI cancer were identified during the 30-year follow-up period. After adjusting for multiple factors, the incidence rate of UGI cancer in participants who drank tap water was significantly lower compared with individuals in the control (HR = 0.91, 95% CI: 0.86–0.97). A similar association was observed between tap water drinking and EC incidence (HR = 0.89, 95% CI: 0.82–0.97). The association between drinking tap water and risk of UGI cancer and EC incidence did not vary across the subgroup by age and gender (All Pinteraction > 0.05). For EC incidence, an interaction effect was observed for riboflavin/niacin supplements and drinking water source (Pinteraction = 0.03). No association was observed between drinking water source and GC incidence. Conclusions In this prospective cohort study in Linxian, participants who drank tap water had a lower risk of EC incidence. As a source of drinking water, use of tap water may reduce the risk of EC by avoiding exposure to nitrate/nitrite. Measures should be taken to improve the quality of drinking water in high-incidence areas of EC. Trial registration The trial is registered with ClinicalTrials.gov (NCT00342654, 21/06/2006), and the trial name is Nutrition Intervention Trials in Linxian Follow-up Study.

show abstract

Oral leukoplakia and the long‐term risk of upper gastrointestinal cancer deaths in the Linxian dysplasia population

Cited by 5 publications

References 41 publications

Weight change and all-cause and cause-specific mortality: A 25-year follow-up study

Weight change and all-cause and cause-specific mortality: A 25-year follow-up study

The Association Between Family History of Upper Gastrointestinal Cancer and the Risk of Death from Upper Gastrointestinal Cancer–based on Linxian Dysplasia Nutrition Intervention Trial (NIT) Cohort

Association between type of drinking water and upper gastrointestinal cancer incidence in the Linxian General Population

Contact Info

Product

Resources

About