Oral lactoferrin for the treatment of sepsis and necrotizing enterocolitis in neonates

Abstract

The safety and efficacy of different preparations and doses of lactoferrin needs to be established in neonates. Well designed adequately powered randomized multicenter trials are needed to address the efficacy and safety of lactoferrin in the treatment of neonatal sepsis and necrotizing enterocolitis. These trials should evaluate long-term neurodevelopmental and pulmonary outcomes in addition to short-term outcomes (e.g. mortality).

Intestinal Epithelial Barrier Function and Necrotizing Enterocolitis

“…56 Lactoferrin concentration is very high in human colostrum. 57 Oral lactoferrin prophylaxis has been found to reduce the incidence of late-onset sepsis in infants weighing less than 1500 g. 58 Recent work describes its effect on neonatal myeloid cells in their conversion to myeloid-derived-suppressor-cells, thus blocking intestinal inflammation and experimental NEC. 59 While large-scale randomized clinical trials are needed, current evidence does not support a protective effect against NEC of exogenous lactoferrin when given alone.…”

“…59 While large-scale randomized clinical trials are needed, current evidence does not support a protective effect against NEC of exogenous lactoferrin when given alone. [58][59][60] the epItheLIAL LAyer…”

Intestinal Epithelial Barrier Function and Necrotizing Enterocolitis

“…56 Lactoferrin concentration is very high in human colostrum. 57 Oral lactoferrin prophylaxis has been found to reduce the incidence of late-onset sepsis in infants weighing less than 1500 g. 58 Recent work describes its effect on neonatal myeloid cells in their conversion to myeloid-derived-suppressor-cells, thus blocking intestinal inflammation and experimental NEC. 59 While large-scale randomized clinical trials are needed, current evidence does not support a protective effect against NEC of exogenous lactoferrin when given alone.…”

“…59 While large-scale randomized clinical trials are needed, current evidence does not support a protective effect against NEC of exogenous lactoferrin when given alone. [58][59][60] the epItheLIAL LAyer…”

Breast Milk and Saliva Lactoferrin Levels and Postnatal Cytomegalovirus Infection

“…42 In addition, a recent clinical trial found that enteral bovine lactoferrin was safe and protective against bacterial sepsis in preterm infants. 43,44 Identifying an association between postnatal CMV acquisition and lower levels of lactoferrin could provide evidence of a potential role for lactoferrin as a prophylactic agent against postnatal CMV.…”

Datamining a medieval medical text reveals patterns in ingredient choice that reflect biological activity against the causative agents of specified infections

“…; it can also enhance the sensitivity of these microbes to modern antibiotics 90,91 . Clinical research into the antimicrobial potential of breast milk or its component proteins is, however, lacking 92 . It is interesting that donkey milk is suggested as a substitute (Lylye of Medicynes, fol.…”

Intestinal Epithelial Barrier Function and Necrotizing Enterocolitis

“…56 Lactoferrin concentration is very high in human colostrum. 57 Oral lactoferrin prophylaxis has been found to reduce the incidence of late-onset sepsis in infants weighing less than 1500 g. 58 Recent work describes its effect on neonatal myeloid cells in their conversion to myeloid-derived-suppressor-cells, thus blocking intestinal inflammation and experimental NEC. 59 While large-scale randomized clinical trials are needed, current evidence does not support a protective effect against NEC of exogenous lactoferrin when given alone.…”

“…59 While large-scale randomized clinical trials are needed, current evidence does not support a protective effect against NEC of exogenous lactoferrin when given alone. [58][59][60] the epItheLIAL LAyer…”

Breast Milk and Saliva Lactoferrin Levels and Postnatal Cytomegalovirus Infection

“…42 In addition, a recent clinical trial found that enteral bovine lactoferrin was safe and protective against bacterial sepsis in preterm infants. 43,44 Identifying an association between postnatal CMV acquisition and lower levels of lactoferrin could provide evidence of a potential role for lactoferrin as a prophylactic agent against postnatal CMV.…”

Datamining a medieval medical text reveals patterns in ingredient choice that reflect biological activity against the causative agents of specified infections

“…; it can also enhance the sensitivity of these microbes to modern antibiotics 90,91 . Clinical research into the antimicrobial potential of breast milk or its component proteins is, however, lacking 92 . It is interesting that donkey milk is suggested as a substitute (Lylye of Medicynes, fol.…”

Intestinal Epithelial Barrier Function and Necrotizing Enterocolitis

“…56 Lactoferrin concentration is very high in human colostrum. 57 Oral lactoferrin prophylaxis has been found to reduce the incidence of late-onset sepsis in infants weighing less than 1500 g. 58 Recent work describes its effect on neonatal myeloid cells in their conversion to myeloid-derived-suppressor-cells, thus blocking intestinal inflammation and experimental NEC. 59 While large-scale randomized clinical trials are needed, current evidence does not support a protective effect against NEC of exogenous lactoferrin when given alone.…”

“…59 While large-scale randomized clinical trials are needed, current evidence does not support a protective effect against NEC of exogenous lactoferrin when given alone. [58][59][60] the epItheLIAL LAyer…”

Breast Milk and Saliva Lactoferrin Levels and Postnatal Cytomegalovirus Infection

“…42 In addition, a recent clinical trial found that enteral bovine lactoferrin was safe and protective against bacterial sepsis in preterm infants. 43,44 Identifying an association between postnatal CMV acquisition and lower levels of lactoferrin could provide evidence of a potential role for lactoferrin as a prophylactic agent against postnatal CMV.…”

Datamining a medieval medical text reveals patterns in ingredient choice that reflect biological activity against the causative agents of specified infections

“…; it can also enhance the sensitivity of these microbes to modern antibiotics 90,91 . Clinical research into the antimicrobial potential of breast milk or its component proteins is, however, lacking 92 . It is interesting that donkey milk is suggested as a substitute (Lylye of Medicynes, fol.…”