Oral lactoferrin for the treatment of sepsis and necrotizing enterocolitis in neonates

Abstract

The safety and efficacy of different preparations and doses of lactoferrin need to be established in neonates. Well designed adequately powered randomized multicenter trials are needed to address the efficacy and safety of lactoferrin in the treatment of neonatal sepsis and necrotizing enterocolitis. These trials should evaluate long-term neurodevelopmental and pulmonary outcomes in addition to short-term outcomes.

Data Mining a Medieval Medical Text Reveals Patterns in Ingredient Choice That Reflect Biological Activity against Infectious Agents

“…; it can also enhance the sensitivity of these microbes to modern antibiotics (86,87). Clinical research into the antimicrobial potential of breast milk or its component proteins is, however, lacking (88). It is interesting that donkey milk is suggested to be a substitute (Lylye of Medicynes, fol.…”

Data Mining a Medieval Medical Text Reveals Patterns in Ingredient Choice That Reflect Biological Activity against Infectious Agents

“…; it can also enhance the sensitivity of these microbes to modern antibiotics (86,87). Clinical research into the antimicrobial potential of breast milk or its component proteins is, however, lacking (88). It is interesting that donkey milk is suggested to be a substitute (Lylye of Medicynes, fol.…”

Role of probiotics VSL#3 in prevention of suspected sepsis in low birthweight infants in India: a randomised controlled trial

“… 11 12 A Cochrane review showed moderate to low quality evidence that oral lactoferrin with or without probiotics decreases sepsis and NEC in preterm infants. 25 The mechanism for efficacy of probiotics in reducing the incidence of sepsis in VLBW infants is probably similar to that for NEC. 26 11 However, in a further study by Lin et al , 12 the effect of reduction in the incidence of sepsis was not confirmed.…”

Breast Milk and Saliva Lactoferrin Levels and Postnatal Cytomegalovirus Infection

“…42 In addition, a recent clinical trial found that enteral bovine lactoferrin was safe and protective against bacterial sepsis in preterm infants. 43,44 Identifying an association between postnatal CMV acquisition and lower levels of lactoferrin could provide evidence of a potential role for lactoferrin as a prophylactic agent against postnatal CMV.…”

Data Mining a Medieval Medical Text Reveals Patterns in Ingredient Choice That Reflect Biological Activity against Infectious Agents

“…; it can also enhance the sensitivity of these microbes to modern antibiotics (86,87). Clinical research into the antimicrobial potential of breast milk or its component proteins is, however, lacking (88). It is interesting that donkey milk is suggested to be a substitute (Lylye of Medicynes, fol.…”

Role of probiotics VSL#3 in prevention of suspected sepsis in low birthweight infants in India: a randomised controlled trial

“… 11 12 A Cochrane review showed moderate to low quality evidence that oral lactoferrin with or without probiotics decreases sepsis and NEC in preterm infants. 25 The mechanism for efficacy of probiotics in reducing the incidence of sepsis in VLBW infants is probably similar to that for NEC. 26 11 However, in a further study by Lin et al , 12 the effect of reduction in the incidence of sepsis was not confirmed.…”

Breast Milk and Saliva Lactoferrin Levels and Postnatal Cytomegalovirus Infection

“…42 In addition, a recent clinical trial found that enteral bovine lactoferrin was safe and protective against bacterial sepsis in preterm infants. 43,44 Identifying an association between postnatal CMV acquisition and lower levels of lactoferrin could provide evidence of a potential role for lactoferrin as a prophylactic agent against postnatal CMV.…”

Data Mining a Medieval Medical Text Reveals Patterns in Ingredient Choice That Reflect Biological Activity against Infectious Agents

“…; it can also enhance the sensitivity of these microbes to modern antibiotics (86,87). Clinical research into the antimicrobial potential of breast milk or its component proteins is, however, lacking (88). It is interesting that donkey milk is suggested to be a substitute (Lylye of Medicynes, fol.…”

Role of probiotics VSL#3 in prevention of suspected sepsis in low birthweight infants in India: a randomised controlled trial

“… 11 12 A Cochrane review showed moderate to low quality evidence that oral lactoferrin with or without probiotics decreases sepsis and NEC in preterm infants. 25 The mechanism for efficacy of probiotics in reducing the incidence of sepsis in VLBW infants is probably similar to that for NEC. 26 11 However, in a further study by Lin et al , 12 the effect of reduction in the incidence of sepsis was not confirmed.…”

Breast Milk and Saliva Lactoferrin Levels and Postnatal Cytomegalovirus Infection

“…42 In addition, a recent clinical trial found that enteral bovine lactoferrin was safe and protective against bacterial sepsis in preterm infants. 43,44 Identifying an association between postnatal CMV acquisition and lower levels of lactoferrin could provide evidence of a potential role for lactoferrin as a prophylactic agent against postnatal CMV.…”