Oral immunoglobulin for preventing necrotizing enterocolitis in preterm and low birth weight neonates

Abstract

Oral immunoglobulin for preventing necrotizing enterocolitis in preterm and low birth weight neonates (Review)

Enteral Feeding Interventions in the Prevention of Necrotizing Enterocolitis: A Systematic Review of Experimental and Clinical Studies

“…Enteral glutamine supplementation did not reduce NEC incidence in a meta-analysis [228]; certainty evidence was low (GRADE approach). Oral administration of IgG or a combination of IgG and IgA did not result in a reduced incidence of NEC (RR 0.84, 95% CI 0.57-1.25), need for NEC related surgery (RR 0.21, 95% CI 0.02-1.75) or death from NEC (RR 1.10, 95% CI 0.47-2.59) in a meta-analysis [229], with low to very low certainty of evidence (GRADE approach).…”

Enteral Feeding Interventions in the Prevention of Necrotizing Enterocolitis: A Systematic Review of Experimental and Clinical Studies

“…Enteral glutamine supplementation did not reduce NEC incidence in a meta-analysis [228]; certainty evidence was low (GRADE approach). Oral administration of IgG or a combination of IgG and IgA did not result in a reduced incidence of NEC (RR 0.84, 95% CI 0.57-1.25), need for NEC related surgery (RR 0.21, 95% CI 0.02-1.75) or death from NEC (RR 1.10, 95% CI 0.47-2.59) in a meta-analysis [229], with low to very low certainty of evidence (GRADE approach).…”

Maternal IgA protects against the development of necrotizing enterocolitis in preterm infants

“…Previous attempts to prevent NEC with intravenous immunoglobulins have largely failed to show efficacy 38 , 39 . However, the repertoire of intravenous antibodies may differ from that of secretory IgA and bacterial specificity was not accounted for in these studies.…”

Percepción del equipo de salud sobre los beneficios del calostro como factor protector de enterocolitis necrotizante en recién nacidos prematuros

“…Respecto al primero, varios participantes plantean que la evidencia científica es aún insuficiente, lo que refleja la discusión científica internacional. Acorde a ésta, hay estudios que favorecen la praxis de suministro enteral trófico con calostro de la madre de las primeras horas de vida, mientras otros discuten su utilidad o nivel de evidencia para la prevención de morbimortalidad neonatal, y específicamente, de ECN 10,11,14,16,17,[26][27][28][29][30][31][32][33] . Otra razón aducida por algunos participantes es el desconocimiento del conjunto de experiencias desarrolladas en Chile.…”

Enteral Feeding Interventions in the Prevention of Necrotizing Enterocolitis: A Systematic Review of Experimental and Clinical Studies

“…Enteral glutamine supplementation did not reduce NEC incidence in a meta-analysis [228]; certainty evidence was low (GRADE approach). Oral administration of IgG or a combination of IgG and IgA did not result in a reduced incidence of NEC (RR 0.84, 95% CI 0.57-1.25), need for NEC related surgery (RR 0.21, 95% CI 0.02-1.75) or death from NEC (RR 1.10, 95% CI 0.47-2.59) in a meta-analysis [229], with low to very low certainty of evidence (GRADE approach).…”

Maternal IgA protects against the development of necrotizing enterocolitis in preterm infants

“…Previous attempts to prevent NEC with intravenous immunoglobulins have largely failed to show efficacy 38 , 39 . However, the repertoire of intravenous antibodies may differ from that of secretory IgA and bacterial specificity was not accounted for in these studies.…”

Percepción del equipo de salud sobre los beneficios del calostro como factor protector de enterocolitis necrotizante en recién nacidos prematuros

“…Respecto al primero, varios participantes plantean que la evidencia científica es aún insuficiente, lo que refleja la discusión científica internacional. Acorde a ésta, hay estudios que favorecen la praxis de suministro enteral trófico con calostro de la madre de las primeras horas de vida, mientras otros discuten su utilidad o nivel de evidencia para la prevención de morbimortalidad neonatal, y específicamente, de ECN 10,11,14,16,17,[26][27][28][29][30][31][32][33] . Otra razón aducida por algunos participantes es el desconocimiento del conjunto de experiencias desarrolladas en Chile.…”

Enteral Feeding Interventions in the Prevention of Necrotizing Enterocolitis: A Systematic Review of Experimental and Clinical Studies

“…Enteral glutamine supplementation did not reduce NEC incidence in a meta-analysis [228]; certainty evidence was low (GRADE approach). Oral administration of IgG or a combination of IgG and IgA did not result in a reduced incidence of NEC (RR 0.84, 95% CI 0.57-1.25), need for NEC related surgery (RR 0.21, 95% CI 0.02-1.75) or death from NEC (RR 1.10, 95% CI 0.47-2.59) in a meta-analysis [229], with low to very low certainty of evidence (GRADE approach).…”

Maternal IgA protects against the development of necrotizing enterocolitis in preterm infants

“…Previous attempts to prevent NEC with intravenous immunoglobulins have largely failed to show efficacy 38 , 39 . However, the repertoire of intravenous antibodies may differ from that of secretory IgA and bacterial specificity was not accounted for in these studies.…”

Percepción del equipo de salud sobre los beneficios del calostro como factor protector de enterocolitis necrotizante en recién nacidos prematuros

“…Respecto al primero, varios participantes plantean que la evidencia científica es aún insuficiente, lo que refleja la discusión científica internacional. Acorde a ésta, hay estudios que favorecen la praxis de suministro enteral trófico con calostro de la madre de las primeras horas de vida, mientras otros discuten su utilidad o nivel de evidencia para la prevención de morbimortalidad neonatal, y específicamente, de ECN 10,11,14,16,17,[26][27][28][29][30][31][32][33] . Otra razón aducida por algunos participantes es el desconocimiento del conjunto de experiencias desarrolladas en Chile.…”