Oral hairy leukoplakia is seen in immunossupressed persons caused particularly by human immunodeficiency virus or organ-transplanted subjects and in individuals presenting malignant neoplasias. Epstein-Barr virus (EBV) is associated with hairy leukoplakia and its presence must be proved to confirm the diagnosis. We report a case of oral hairy leukoplakia like-lesion in a immunocompetent young person where in situ hybridization was EBV negative.