Oral Hairy Leukoplakia

Zunt, Susan L.; Tomich, Charles E.

doi:10.1111/j.1524-4725.1990.tb01566.x

Cited by 7 publications

(1 citation statement)

References 33 publications

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“…EBV is associated with lymphoid and epithelial cancers, including Burkitt’s lymphoma, Hodgkin’s disease, and nasopharyngeal and gastric malignancies [2–8]. In immunocompromised individuals, EBV is associated with diverse complications including immunoblastic lymphomas and oral hairy leukoplakia, an epithelial lesion [9–11]. …”

Section: Introductionmentioning

confidence: 99%

Characteristics of Epstein–Barr virus envelope protein gp42

et al. 2010

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Epstein-Barr virus (EBV) glycoprotein 42 (gp42) is a membrane protein essential for fusion and entry of EBV into host B-lymphocytes. Gp42 is a member of the protein fold family C-type lectin or lectin-like domains (CLECT or CTLD) and specifically is classified as a natural-killer receptor (NKR)- like CLECT. Literature review and phylogenetic comparison show that EBV gp42 shares a common structure with other NKR-like CLECTs and possibly with many viral CTLDs, but does not appear to exhibit some common binding characteristics of many CTLDs, such as features required for calcium binding. The flexible N-terminal region adjacent to the CTLD fold is important for binding to other EBV glycoproteins and for a cleavage site that is necessary for infection of host cells. From structural studies of gp42 unbound and bound to receptor and extensive mutational analysis, a general model of how gp42 triggers membrane fusion utilizing both the flexible N-terminal region and the CTLD domain has emerged.

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Section: Introductionmentioning

confidence: 99%