2002
DOI: 10.1080/10915810290096432
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Abstract: In a two-generation study of dibromoacetic acid (DBA), Crl SD rats (30 rats/sex/group/generation) were provided DBA in drinking water at 0 (reverse osmosis-deionized water), 50, 250, and 650 ppm (0, 4.4 to 11.6, 22.4 to 55.6, and 52.4 to 132.0 mg/kg/day, respectively; human intake approximates 0.1 microg/kg/day [0.0001 mg/kg/day]). Observations included viability, clinical signs, water and feed consumption, body and organ weights, histopathology, and reproductive parameters (mating, fertility, abortions, prema… Show more

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Cited by 36 publications
(18 citation statements)
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References 53 publications
(76 reference statements)
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“…Several animal studies have linked exposure to brominated HAA with male reproductive defects,2832 including histopathologic changes in the testes and epididymis of rats 33. No laboratory studies have been conducted to support a relationship between exposure to TTHM and hypospadias, likely due to the rarity of hypospadias among laboratory animals.…”
Section: Discussionmentioning
confidence: 99%
“…Several animal studies have linked exposure to brominated HAA with male reproductive defects,2832 including histopathologic changes in the testes and epididymis of rats 33. No laboratory studies have been conducted to support a relationship between exposure to TTHM and hypospadias, likely due to the rarity of hypospadias among laboratory animals.…”
Section: Discussionmentioning
confidence: 99%
“…Routes of exposure to THMs include dermal absorption during hand washing and bathing, inhalation during showering and ingestion of drinking water [28]. Animal studies have consistently demonstrated an association between oral exposure to DBPs including haloacetic acids (HAAs) and trihalomethanes and adverse effects in male reproductive system: acute spermatoxicity, impaired reproductive competence, sperm quality [29], delayed spermiation and distorted sperm motility and morphology [30], histopathologic changes in testis and epididymis [31], transient subfertility [32], altered sperm production and epididymal tubule changes [33].…”
Section: Trihalomethanes In Tap Watermentioning
confidence: 99%
“…Neither sodium chlorate nor DBAA were found to be teratogenic in rodents. (IARC 2000;Christian et al 2002) Our frog embryo results show that malformations do not occur until sodium chlorate or DBAA concentrations approach lethal levels. Skeletal abnormalities seen in rats exposed to BDCM (Christian et al 2000) may compare with notochord maldevelopment seen in our Xenopus embryos.…”
Section: C)mentioning
confidence: 96%