Oral contraceptive use changes brain activity and mood in women with previous negative affect on the pill—A double-blinded, placebo-controlled randomized trial of a levonorgestrel-containing combined oral contraceptive

Gingnell, Malin; Engman, Jonas; Frick, Andreas; Moby, Lena; Wikström, Johan; Fredrikson, Mats; Sundström‐Poromaa, Inger

doi:10.1016/j.psyneuen.2012.11.006

Cited by 126 publications

(111 citation statements)

References 62 publications

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“…We found that women who had changed a hormonal contraceptive method because of a decrease in sexual desire had about an eightfold increased odds of considering stopping or changing their hormonal contraceptive method again, which is consistent with earlier findings 25 . Recall bias must, however, be considered and the calculated OR should be interpreted with some caution.…”

Section: Similarities and Differencessupporting

confidence: 91%

“…Half of the 13 women who used the LNG-IUS and reported reduced sexual desire had experienced the same adverse effect earlier with another hormonal contraceptive method. In a small randomised clinical trial, Gingnell et al 25 showed that women with subjective reports of previous COC-induced mood deterioration displayed depressed mood and mood swings when re-exposed to COCs.…”

Section: Similarities and Differencesmentioning

confidence: 99%

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Hormonal contraception and sexual desire: A questionnaire-based study of young Swedish women

Malmborg

Persson

Brynhildsen

et al. 2015

The European Journal of Contraception & Reproductive Health

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Section: Similarities and Differencessupporting

confidence: 91%

Section: Similarities and Differencesmentioning

confidence: 99%

Hormonal contraception and sexual desire: A questionnaire-based study of young Swedish women

Malmborg

Persson

Brynhildsen

et al. 2015

The European Journal of Contraception & Reproductive Health

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“…In the study by Nyberg (22) with the aim of improving the physical and mood symptoms in women using third generation OCPs, results showed that the level of negative mood reduced and positive mood increased 3 months after taking 250 mg norgestimat and 35 mg ethinyl estradiol. Another study reported that in women taking second generation of oral contraceptives, mood swings, depression and fatigue was higher than the control group receiving placebo (23) and other studies have also reported that the level of negative mood increased in second generation oral contraceptives consumers (24-26). …”

Section: Discussionmentioning

confidence: 93%

A Comparison of Second and Third Generations Combined Oral Contraceptive Pills’ Effect on Mood

Shahnazi

Khalili

Kochaksaraei

et al. 2014

Iran Red Crescent Med J

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Background:Most women taking combined oral contraceptives (COCs) are satisfied with their contraceptive method. However, one of the most common reasons reported for discontinuation of combined oral contraceptives (COCs) is mood deterioration.Objectives:This study aimed to compare effects of the second and third generation oral contraceptive pills on the mood of reproductive women.Materials and Methods:This randomized, double-blind, controlled clinical trial was conducted in reproductive women at health centers in Tehran, Iran. Participants were randomized into the second and third generation oral contraceptive groups. Positive and negative moods were recorded using positive affect, negative affect scale (PANAS) tools at the end the second and fourth months of the study. Data analysis was carried out using ANOVA and P Values < 0.05 was considered significant.Results:Statistically significant difference was seen in positive and negative mood changes in women receiving contraceptive pills. The second generation oral contraceptive pills resulted in a decrease in positive mood (95% CI: 43.39 to 38.32 in second month and 43.39 to 26.05 in four month) and increase in negative mood (95% CI: 14.23 to 22.04 in second month and 14.23 to 32.26 in four month - P < 0.001), but the third generation led to an increase in positive mood (95% CI: 22.42 to 25.60 in second month and 22.42 to 33.87 in four month) and decrease in negative mood (95% CI: 36.78 to 31.97 in second month and 36.78 to 22.65 in four month - P < 0.001).Conclusions:Third generation combined oral contraceptive pills have a better effect on mood in women in reproductive ages than the second generation pills. It can be recommended as a proper combined oral contraceptive in Iran.

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“…T deficiency in women has been associated with a broad range of undesired effects [3,4], some of which, including mood disturbances and interference with sexual function, have been reported as side effects of COCs [5][6][7][8]. Normalizing total T and other androgen levels in women using a COC may be achieved by the co-administration of the natural human adrenal androgen dehydroepiandrosterone (DHEA), because it is orally bioavailable [9] and partially metabolized into T [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Restoring testosterone levels by adding dehydroepiandrosterone to a drospirenone containing combined oral contraceptive: I. Endocrine effects

et al. 2015

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Oral contraceptive use changes brain activity and mood in women with previous negative affect on the pill—A double-blinded, placebo-controlled randomized trial of a levonorgestrel-containing combined oral contraceptive

Cited by 126 publications

References 62 publications

Hormonal contraception and sexual desire: A questionnaire-based study of young Swedish women

Hormonal contraception and sexual desire: A questionnaire-based study of young Swedish women

A Comparison of Second and Third Generations Combined Oral Contraceptive Pills’ Effect on Mood

Restoring testosterone levels by adding dehydroepiandrosterone to a drospirenone containing combined oral contraceptive: I. Endocrine effects

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