Oral Carcinoma Cuniculatum: A  New Entity in the Clinicopathological  Spectrum of Oral Squamous Cell  Carcinoma

Datar, Uma Vasant; Kale, Alka D; Mane, Deepa

doi:10.7860/jcdr/2017/23437.9226

Cited by 23 publications

(31 citation statements)

References 10 publications

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“…Oral carcinoma cuniculatum (CC) is a rare, unacquainted variant of oral squamous cell carcinoma (OSCC) 1. It is similar to cutaneous CC, which was first described by Aird et al in 1954, in its clinicopathological findings and biological behavior 2…”

Section: Introductionmentioning

confidence: 99%

Oral carcinoma cuniculatum, an unacquainted variant of oral squamous cell carcinoma: A systematic review

2018

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PurposeOral carcinoma cuniculatum is a rare well-differentiated variant of oral squamous cell carcinoma. The purpose was to systematically review its unique features to differentiate it from other variants as verrucous carcinoma, papillary squamous cell carcinoma and well-differentiated squamous cell carcinoma.Materials and MethodsA systematic review was performed using MEDLINE, Dentistry and Oral Sciences Source and PubMed databases and any existing articles related to the research subject missed in the search strategy to screen ones reporting cases occurring exclusively in the oral cavity in English literature. Variables analyzed included clinical, etiologic, imaging, histopatholgical features, treatment, follow-up and survival rates.ResultsFrom 229 hits, 17 articles with 43 cases were included in the systematic review. Clinically it showed a female predilection with pain and/or ulceration of a relatively long duration and exudation being the most common symptoms. Histologically, it showed more endophytic features comprising well-differentiated squamous epithelium with absent or minimal cytological atypia and multiple keratin filled crypts or cuniculus. Inflammatory stromal reaction and discharging abscesses were reported in most of the cases. Bone destruction was predominant in most imaging features. Complete surgical resection with a safety margin was the treatment of choice in most of the cases with few recorded recurrence cases.ConclusionApprehensive knowledge of oral carcinoma cuniculatum unique features is essential to avoid its misdiagnosis and provide proper treatment especially for recurrent cases.

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Section: Introductionmentioning

confidence: 99%

Oral carcinoma cuniculatum, an unacquainted variant of oral squamous cell carcinoma: A systematic review

2018

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“…Oral CC represents 2.7% of oral squamous cell carcinomas [10]. Intraoral sites include attached gingiva, palatal mucosa, tongue, edentulous alveolus and mandible [4]. Our patient had exophytic growth involving buccal and lingual aspect of 47 and also extended over edentulous area adjacent to it.…”

Section: Discussionmentioning

confidence: 66%

“…Clinically it presents as a slow growing, painful and non healing verrucous exophytic mass the surface of which may be papillary, nodular, cobble stone and/or ulcerated [4,9,11]. It appears like an over ripened orange with squashy mass [2].…”

Section: Discussionmentioning

confidence: 99%

“…In this present case lesser staining expressions were observed with p53 and Ki67. Fifty CC cases were reported till date in oral cavity, with low recurrence despite rare metastasis and CC has got better prognosis than oral squamous cell carcinoma and aggressive when compared to verrucous carcinoma [4].…”

Section: Discussionmentioning

confidence: 99%

“…Clinically, it presents as a mucosal exophytic growth, whereas histologically it shows both papilliferous and verrucous growth patterns. It is a rare entity and till date only 50 cases involving the oral cavity have been reported in the literature [4]. We hereby report a case of CC involving the mandibular alveolar mucosa of a female patient.…”

Section: Introductionmentioning

confidence: 87%

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Carcinoma Cuniculatum of the Alveolar Mucosa: A Rare Variant of Squamous Cell Carcinoma

Sivapathasundharam

Kavitha

Padmapriya

2018

Head and Neck Pathol

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Carcinoma cuniculatum is one of the variants of squamous cell carcinoma. It is significantly rare with an incidence rate < 1% compared to other histological variants of squamous cell carcinoma. Various etiologic factors implicated are trauma, HPV, chronic inflammation and alcohol consumption but real causative agent still remains unclear. Initially it resembles plantar wart which slowly progress to bulky exophytic mass in the sole of the foot, where cases have been reported first. In the oral cavity it presents clinically as an exophytic growth and slowly invades the jaw and destroys the underlying bone. Microscopically it exhibits as both exophytic and endophytic epithelial masses along with well differentiated and pronounced hyperkeratosis. Treatment includes surgical resection alone unlike other variants which are treated by radiation with or without chemotherapy. Here we present a case of carcinoma cuniculatum occurred in alveolar mucosa of a 47 years old female. It presented as an exophytic growth in mandibular alveolar region, with histological features consistent with carcinoma cuniculatum.

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Cuneiform (cuniculatum) variant of oral squamous cell carcinoma revisited: Presentation of two cases and literature review of a rare entity

et al. 2022

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Background Oral carcinoma cuniculatum (OCC) is a rare, locally aggressive tumor, which tends to invade underlying bone. We present two cases of OCC, one demonstrating invasion of the mandible and the other limited to the tongue. Methods An 87‐year‐old male presented with a right‐sided buccogingival lesion. Biopsy results led to a diagnosis of verrucous hyperplasia, which was later revised to OCC. Additionally, a 94‐year‐old female presented with a left lateral tongue lesion. A biopsy showed in‐situ and invasive keratinizing squamous cell carcinoma that was later defined as a soft tissue OCC. Results Following surgical resection, the diagnosis of OCC was established in both patients. We provide a comprehensive literature review of OCC in the context of both case presentations. Conclusions OCC is a rare entity, which has a tendency to be misdiagnosed. We emphasize the importance of recognizing the common features of OCC in order to aid in accurate diagnosis.

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Oral Carcinoma Cuniculatum: A New Entity in the Clinicopathological Spectrum of Oral Squamous Cell Carcinoma

Cited by 23 publications

References 10 publications

Oral carcinoma cuniculatum, an unacquainted variant of oral squamous cell carcinoma: A systematic review

Oral carcinoma cuniculatum, an unacquainted variant of oral squamous cell carcinoma: A systematic review

Carcinoma Cuniculatum of the Alveolar Mucosa: A Rare Variant of Squamous Cell Carcinoma

Cuneiform (cuniculatum) variant of oral squamous cell carcinoma revisited: Presentation of two cases and literature review of a rare entity

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