Oral candidiasis of COVID‐19 patients: Case report and review of evidence

Riad, Abanoub; Gomaa, Esraa; Hocková, Barbora; Klugar, Miloslav

doi:10.1111/jocd.14066

Cited by 51 publications

(80 citation statements)

References 15 publications

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“…This study provides the first evidence on oral SE following CoronaVac administration including oral ulcerations (4.4%), dysgeusia (0.9%), and oral paresthesia (0.3%). However, oral SEs were rarely reported, and some of these oral mucocutaneous lesions and oral conditions were previously reported by COVID-19 patients [28][29][30][31][32][33][34].…”

Section: Discussionmentioning

confidence: 98%

Prevalence and Risk Factors of CoronaVac Side Effects: An Independent Cross-Sectional Study among Healthcare Workers in Turkey

Riad

Sağıroğlu

Üstün

et al. 2021

JCM

Self Cite

119

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Background: COVID-19 vaccine hesitancy is a serious threat to mass vaccination strategies that need to be accelerated currently in order to achieve a substantial level of community immunity. Independent (non-sponsored) studies have a great potential to enhance public confidence in vaccines and accelerate their uptake process. Methods: A nationwide cross-sectional study for the side effects (SE) of CoronaVac was carried out in February 2021 among Turkish healthcare workers who were recently vaccinated. The questionnaire inquired about local and systemic SEs that occurred in the short-term, within four weeks, following vaccination. Results: A total of 780 healthcare workers were included in this study; 62.5% of them experienced at least one SE. Injection site pain (41.5%) was the most common local SE, while fatigue (23.6%), headache (18.7%), muscle pain (11.2%) and joint pain (5.9%) were the common systemic SEs. Female healthcare workers (67.9%) were significantly more affected by local and systemic SEs than male colleagues (51.4%). Younger age, previous infection, and compromised health status (chronic illnesses and regular medicines uptake) can be associated with an increased risk of CoronaVac SEs; Conclusions: The independent research shows a higher prevalence of CoronaVac SEs than what is reported by phase I–III clinical trials. In general, the results of this study confirm the overall safety of CoronaVac and suggest potential risk factors for its SEs. Gender-based differences and SEs distribution among age groups are worth further investigation.

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Section: Discussionmentioning

confidence: 98%

Prevalence and Risk Factors of CoronaVac Side Effects: An Independent Cross-Sectional Study among Healthcare Workers in Turkey

Riad

Sağıroğlu

Üstün

et al. 2021

JCM

Self Cite

119

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“…Heterozygous Factor V Leiden mutation was suspected to be the trigger of the thromboembolic events that were experienced by the patient, in addition to being a predisposing factor for the oral mucositis episode that followed the COVID-19 vaccination [ 49 , 50 ]. Oral mucosal lesions were increasingly reported in COVID-19 patients in the last months; therefore, the oral side effects of COVID-19 vaccines may mimic the COVID-19-associated oral symptoms [ 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 ].…”

Section: Discussionmentioning

confidence: 99%

Side Effects of mRNA-Based and Viral Vector-Based COVID-19 Vaccines among German Healthcare Workers

Klugar

Riad

Mekhemar

et al. 2021

Biology

Self Cite

185

157

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Background: the increasing number of COVID-19 vaccines available to the public may trigger hesitancy or selectivity towards vaccination. This study aimed to evaluate the post-vaccination side effects of the different vaccines approved in Germany; Methods: a cross-sectional survey-based study was carried out using an online questionnaire validated and tested for a priori reliability. The questionnaire inquired about demographic data, medical and COVID-19-related anamneses, and local, systemic, oral, and skin-related side effects following COVID-19 vaccination; Results: out of the 599 participating healthcare workers, 72.3% were females, and 79.1% received mRNA-based vaccines, while 20.9% received a viral vector-based vaccine. 88.1% of the participants reported at least one side effect. Injection site pain (75.6%) was the most common local side effect, and headache/fatigue (53.6%), muscle pain (33.2%), malaise (25%), chills (23%), and joint pain (21.2%) were the most common systemic side effects. The vast majority (84.9%) of side effects resolved within 1–3 days post-vaccination; Conclusions: the mRNA-based vaccines were associated with a higher prevalence of local side effects (78.3% vs. 70.4%; Sig. = 0.064), while the viral vector-based vaccine was associated with a higher prevalence of systemic side effects (87.2% vs. 61%; Sig. < 0.001). Females and the younger age group were associated with an increased risk of side effects either after mRNA-based or viral vector-based vaccines. The gender- and age-based differences warrant further rigorous investigation and standardized methodology.

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“…The oral cavity represents a vital locus for exhibiting extrapulmonary symptoms of SARS-CoV-2 [49][50][51]. The oral manifestations of COVID-19 patients varied significantly, and they included dysgeusia, xerostomia, aphthous stomatitis, herpetic ulcers, oral mucositis, salivary gland involvement, and fungal co-infections such as oral candidiasis and mucormycosis [49,[52][53][54][55][56][57][58][59][60]. However, the pathophysiology of these symptoms is not fully understood, and a number of hypotheses have been proposed to explain them, including inflammatory response; the direct infiltration of SARS-CoV-2 to the lining epithelium of the oral cavity, which was found to be rich with angiotensin-converting enzyme 2 (ACE2) receptors; and secondary infection [49,50].…”

Section: Discussionmentioning

confidence: 99%

Side Effects of mRNA-Based COVID-19 Vaccine: Nationwide Phase IV Study among Healthcare Workers in Slovakia

et al. 2021

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mRNA-based COVID-19 vaccines such as BNT162b2 have recently been a target of anti-vaccination campaigns due to their novelty in the healthcare industry; nevertheless, these vaccines have exhibited excellent results in terms of efficacy and safety. As a consequence, they acquired the first approvals from drug regulators and were deployed at a large scale among priority groups, including healthcare workers. This phase IV study was designed as a nationwide cross-sectional survey to evaluate the post-vaccination side effects among healthcare workers in Slovakia. The study used a validated self-administered questionnaire that inquired about participants’ demographic information, medical anamneses, COVID-19-related anamnesis, and local, systemic, oral, and skin-related side effects following receiving the BNT162b2 vaccine. A total of 522 participants were included in this study, of whom 77% were females, 55.7% were aged between 31 and 54 years, and 41.6% were from Banska Bystrica. Most of the participants (91.6%) reported at least one side effect. Injection site pain (85.2%) was the most common local side effect, while fatigue (54.2%), headache (34.3%), muscle pain (28.4%), and chills (26.4%) were the most common systemic side effects. The reported side effects were of a mild nature (99.6%) that did not require medical attention and a short duration, as most of them (90.4%) were resolved within three days. Females and young adults were more likely to report post-vaccination side effects; such a finding is also consistent with what was previously reported by other phase IV studies worldwide. The role of chronic illnesses and medical treatments in post-vaccination side effect incidence and intensity requires further robust investigation among large population groups.

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Oral candidiasis of COVID‐19 patients: Case report and review of evidence

Cited by 51 publications

References 15 publications

Prevalence and Risk Factors of CoronaVac Side Effects: An Independent Cross-Sectional Study among Healthcare Workers in Turkey

Prevalence and Risk Factors of CoronaVac Side Effects: An Independent Cross-Sectional Study among Healthcare Workers in Turkey

Side Effects of mRNA-Based and Viral Vector-Based COVID-19 Vaccines among German Healthcare Workers

Side Effects of mRNA-Based COVID-19 Vaccine: Nationwide Phase IV Study among Healthcare Workers in Slovakia

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