Cochrane Database of Systematic Reviews 2010
Oral budesonide for induction of remission in ulcerative colitis
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Cited by 43 publications
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“…It has an high affinity for the glucocorticoid receptor, and combines an excellent solubility with a strong anti-inflammatory activity. Budesonide exerts its role through a significant downregulation of the inflammation pathways, downregulating several proinflammatory cytokines as tumour necrosis factor-α, IL-1 and 6 (IL-6), and nuclear factor kappa-B 13 14. Budesonide has also lower systemic adverse events when compared with systemic steroids, and the most common of them are Cushingoid face and hypokalemia (due to effects on the endocrine organs) 15…”
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confidence: 99%