Oral benfotiamine plus α-lipoic acid normalises complication-causing pathways in type 1 diabetes

Du, Xing; Edelstein, Diane; Brownlee, Michael

doi:10.1007/s00125-008-1100-2

Cited by 89 publications

(73 citation statements)

References 11 publications

(13 reference statements)

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“…Arora et al [56] Thiamine Improved endothelial-dependent vasodilation in subjects with impaired glucose tolerance and in T2DM patients Du et al [57] Benfotiamine + α-lipoic acid Normalization of AGEs production and prostacyclin synthase activity and decreases hexosamine-modified protein in monocytes without changing glycaemic control in T1DM González-Ortiz et al [58] Thiamine…”

Section: Treatment Resultsmentioning

confidence: 99%

Evidence for altered thiamine metabolism in diabetes: Is there a potential to oppose gluco- and lipotoxicity by rational supplementation?

Pácal¹

2014

WJD

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Growing prevalence of diabetes (type 2 as well as type 1) and its related morbidity due to vascular complications creates a large burden on medical care worldwide. Understanding the molecular pathogenesis of chronic micro-, macro-and avascular complications mediated by hyperglycemia is of crucial importance since novel therapeutic targets can be identified and tested. Thiamine (vitamin B1) is an essential cofactor of several enzymes involved in carbohydrate metabolism and published data suggest that thiamine metabolism in diabetes is deficient. This review aims to point out the physiological role of thiamine in metabolism of glucose and amino acids, to present overview of thiamine metabolism and to describe the consequences of thiamine deficiency (either clinically manifest or latent). Furthermore, we want to explain why thiamine demands are increased in diabetes and to summarise data indicating thiamine mishandling in diabetics (by review of the studies mapping the prevalence and the degree of thiamine deficiency in diabetics). Finally, we would like to summarise the evidence for the beneficial effect of thiamine supplementation in progression of hyperglycemia-related pathology and, therefore, to justify its importance in determining the harmful impact of hyperglycemia in diabetes. Based on the data presented it could be concluded that although experimental studies mostly resulted in beneficial effects, clinical studies of appropriate size and duration focusing on the effect of thiamine supplementation/therapy on hard endpoints are missing at present. Moreover, it is not currently clear which mechanisms contribute to the deficient action of thiamine in diabetes most. Experimental studies on the molecular mechanisms of thiamine deficiency in diabetes are critically needed before clear answer to diabetes community could be given. Key words: Diabetes; Thiamine; Vitamin B1; Transketolase; Benfotiamine; Hyperglycemia; Nephropathy; Metabolic syndrome; Cardiovascular disease; Chronic kidney disease Core tip: Published data suggest deficient action of thiamine in diabetes, however, it is not currently clear by which mechanisms. Plasma levels might be decreased in diabetics (although renal function has a prevailing effect), nevertheless, intracellular concentration of thiamine diphosphate is the crucial parameter and there is not a direct relationship with the plasma thiamine since the rate of transmembrane transport (via thiamine transporters) and intracellular activation by thiamine pyrophosphokinase might affected by hyperglycemia at first place. Experimental studies on the molecular mechanisms of thiamine deficiency in diabetes are critically needed before clear answer to diabetes community could be given.

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Section: Treatment Resultsmentioning

confidence: 99%

Evidence for altered thiamine metabolism in diabetes: Is there a potential to oppose gluco- and lipotoxicity by rational supplementation?

Pácal¹

2014

WJD

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“…According to these studies antioxidant supplementation such as vitamin use, may not be the ideal antioxidant strategy in human diabetic nephropathy. However, some studies that used combined antioxidants therapy or antioxidant with anti-inflammatory agent showed that improvement of albuminuria, HbA1C and MDA in diabetic patients (49)(50)(51)(52).…”

Section: Discussionmentioning

confidence: 99%

Diabetic nephropathy and antioxidants

Tavafi¹

2013

J Nephropathol

132

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“…Pyridoxine is also involved in the protein metabolism and partly in the fat metabolism. Both vitamins potentiate the action of each other [1, 8,9,10,12,13].…”

Section: The Studies In Selecting the Optimal Technology For Obtaininmentioning

confidence: 99%

Some aspects of developing the production technology for combined tablets based on B vitamins

Zhydkova

Krutskykh

2015

Vìsn. farm.

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Oral benfotiamine plus α-lipoic acid normalises complication-causing pathways in type 1 diabetes

Cited by 89 publications

References 11 publications

Evidence for altered thiamine metabolism in diabetes: Is there a potential to oppose gluco- and lipotoxicity by rational supplementation?

Evidence for altered thiamine metabolism in diabetes: Is there a potential to oppose gluco- and lipotoxicity by rational supplementation?

Diabetic nephropathy and antioxidants

Some aspects of developing the production technology for combined tablets based on B vitamins

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