Oral Anticoagulation and Antiarrhythmic Drug Therapy for Atrial Fibrillation

Reiffel, James A.

doi:10.19102/icrm.2018.091201

Cited by 3 publications

(1 citation statement)

References 29 publications

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“…20,23 The high concomitant use of anticoagulant and antiplatelet agents followed by antihypertensive and lipid-lowering agents in this study and others is explained by the use of these agents for primary or secondary prevention of cardiovascular events or to treat the associated comorbidities in this population. 24,25 Beta-blockers were the most commonly prescribed antiarrhythmic drugs. Similar findings have been reported previously.…”

Section: Discussionmentioning

confidence: 99%

Overview of the use of antiarrhythmic drugs at a tertiary hospital in Oman

et al. 2023

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Background: Antiarrhythmic drugs are commonly used to treat arrhythmia. However, data on the usage pattern of antiarrhythmic drugs, associated side effects, and the role of clinical pharmacist interventions in the Middle East are scarce. Objective: The purpose of this study was to describe the usage pattern, side effects, and clinical pharmacist interventions of antiarrhythmic drugs at the Sultan Qaboos University Hospital (SQUH), a tertiary care hospital in Oman. Methods: This retrospective observational study included adult patients (≥18 years) who received at least one dose of antiarrhythmic drugs at SQUH between January 2020 and December 2021. Ethical approval was obtained prior to conducting the study. Results: In total, 400 patients were enrolled in this study. Their mean age was 62.5 ± 16.6 years (range:19-96), and 55.3% (221/400) were male. Atrial arrhythmias were the most commonly observed (344/400, 86.0%). Beta-blockers (337/500, 67.4%) were the most prescribed class of drugs. The most commonly prescribed drugs were bisoprolol (263/400, 65.8%), carvedilol (65/400, 16.3%), and amiodarone (59/400, 14.8%). The majority of patients (300/400, 75.0%) received monotherapy, whereas 25% (100/400) received combination therapy. A total of 109 side effects were reported in 45 patients, resulting in an incidence rate of 11.3 %, with cardiovascular side effects accounting for the majority (41/109, 37.6%) of these. Amiodarone had the highest prevalence of adverse effects (33/109, 30.3%). A total of 122 clinical pharmacist interventions were observed in 13.0 % (52/400) of patients. Beta-blockers were associated with more than half of the interventions (61/122, 50.0%). Age (61.84 years vs. 66.75 years; p=0.047), comorbidities (83.6% vs. 96.2%; p=0.019), renal impairment (19.6% vs. 40.4%; p=0.001, heart failure (11.8% vs. 28.9%; p=0.002), concomitant medications (84.5% vs. 98.1%; p=0.004), polypharmacy (51.1% vs. 69.2%; p=0.022) and duration of therapy of less than one year (9.3% vs. 27.3%; p<0.001) was significantly associated with the need for intervention. Conclusion: Beta-blockers were the most commonly prescribed antiarrhythmic drugs in SQUH. Amiodarone was associated with the highest prevalence of side effects. Clinical pharmacy intervention at the SQUH was mainly related to antiarrhythmic drug selection and dose optimization.

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Section: Discussionmentioning

confidence: 99%

Overview of the use of antiarrhythmic drugs at a tertiary hospital in Oman

et al. 2023

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A disposable edoxaban sensor chip using carbon paste electrode grafted with molecularly imprinted polymer

2023

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Computer Simulation of Catheter Cryoablation for Pulmonary Vein Isolation

Rivera,

Bernal,

Martínez-Peláez

et al. 2024

Healthcare

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Cryoablation is a well-established medical procedure for surgically treating atrial fibrillation. Cryothermal catheter therapy induces cellular necrosis by freezing the insides of pulmonary veins, with the goal of disrupting abnormal electrical heart signals. Nevertheless, tissue damage induced by cold temperatures may also lead to other complications after cardiac surgery. In this sense, the simulation of catheter ablation can provide safer environments for training and the performance of cryotherapy interventions. Therefore, in this paper, we propose a novel approach to help better understand how temperature rates can affect this procedure by using computer tools to develop a simulation framework to predict lesion size and determine optimal temperature conditions for reducing the risk of major complications. The results showed that a temperature profile of around −40 °C caused less penetration, reduced necrotic damage, and smaller lesion size in the tissue. Instead, cryotherapy close to −60 °C achieved a greater depth of temperature flow inside the tissue and a larger cross-section area of the lesion. With further development and validation, the framework could represent a cost-effective strategy for providing personalized modeling, better planning of cryocatheter-based treatment, and preventing surgical complications.

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Oral Anticoagulation and Antiarrhythmic Drug Therapy for Atrial Fibrillation

Cited by 3 publications

References 29 publications

Overview of the use of antiarrhythmic drugs at a tertiary hospital in Oman

Overview of the use of antiarrhythmic drugs at a tertiary hospital in Oman

A disposable edoxaban sensor chip using carbon paste electrode grafted with molecularly imprinted polymer

Computer Simulation of Catheter Cryoablation for Pulmonary Vein Isolation

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