Oral amyloidosis: an update

Abstract

Background Amyloidosis is a disease characterized by the progressive deposition of abnormal proteins that can occur in any organ. In the oral cavity, the tongue is the most common affected site, usually causing macroglossia. Biopsy is essential for the diagnosis and the occurrence of its systemic form is mandatory to be investigated. This systematic review evaluated the existing information in the literature on Amyloidosis in the oral cavity to allow a more comprehensive and updated analysis of its clinicopathological characteristics, as well as to explore the main forms of treatment and prognostic factors. Material and Methods Electronic searches were undertaken in five databases supplemented by manual scrutiny. Results A total of 111 studies were included with 158 individuals. Conclusions The disease had a higher prevalence in women, the tongue was the most affected site, as well as the systemic form of the disease. The worst prognosis was for cases of systemic amyloidosis associated with multiple myeloma. Key words: Amyloidosis, mouth, Congo red.

The Bloody Crossroads: Interactions between Periodontitis and Hematologic Diseases

“…This can lead to the formation of lumps or plaques, especially on the tongue, contributing to a feeling of stiffness or visible enlargement. Oral amyloidosis in patients with MM is a direct consequence of abnormal protein production by malignant plasma cells and serves as a key diagnostic clue [ 77 , 78 ].…”