Oral aluminum administration and oxidative injury

Katyal, Ranjan; Desigan, B.; Sodhi, Chhinder P.; Ojha, Sudarshan

doi:10.1007/bf02778195

Cited by 40 publications

(30 citation statements)

References 13 publications

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“…In the present experiment, there was a significant increase in lipid peroxidation following AlCl 3 exposure, determined by TBARS and HP levels in rat testes. Our result are in agreement with many authors who have reported a significant increase in TBARS and HP in the kidney, liver and brain of rats exposed to aluminum salts [41,[49][50][51] . Also, our findings correlate with those published by Yousef et al [25] who demonstrated that, in rabbits orally treated with AlCl 3 , there was a significant increase in the level of TBARS in the seminal plasma.…”

Section: Discussionsupporting

confidence: 94%

Camel’s Milk Alleviates Oxidative Stress and Lipid Peroxidation Induced by Chronic Aluminum Chloride Exposure in Rat’s Testes

Al‐Hashem¹

2009

American J. of Applied Sciences

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Problem statement: The present study was carried out to examine the effectiveness of Camel's milk in alleviating aluminum chloride (AlCl 3 )-induced oxidative stress and lipid peroxidation in rat testes. Approach: White albino male rats (230-250 g) were divided into three groups of 10 rats: A control group, treated with normal saline and two experimental groups, the AlCl 3 treated group and the Camel's milk-AlCl 3 treated group. The first experimental group, the AlCl 3 treated group, received 0.5 mg kg −1 of AlCl 3 orally. The second experimental group was fed 1 mL of fresh Camel's milk 10 min prior to the administration of oral AlCl 3 . All rats were treated every day for 30 days. Lipid peroxidation, as determined by testicular concentration of Thiobarbituric Acid Reactive Substances (TBARS) and Hydroperoxide (HP) levels and the oxidative stress status, as measured by glutathione (GSH) levels, Superoxide Dismutase (SOD) and Catalase (CAT) activity, were evaluated in the rat testes. Results: Oral administration of AlCl 3 induced lipid peroxidation and oxidative stress in rat testes, which was indicated by a significant increase in lipid peroxidation biomarkers (TBARS and HP) and a significant decrease in the GSH content and SOD and CAT activities. When rats received Camel's milk before being given AlCl 3 , lipid peroxidation and oxidative stress parameters were restored to normal levels. In the testes from rats fed Camel's milk TBARS and HP levels were significantly reduced and, conversely, GSH content, SOD and CAT activities were significantly increased compared to rats that received only AlCl 3 . Conclusion: Treatment with Camel's milk prior to AlCl 3 alleviates AlCl 3 -associated hazards and protects testicular tissue from AlCl 3 toxicity.

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Section: Discussionsupporting

confidence: 94%

Camel’s Milk Alleviates Oxidative Stress and Lipid Peroxidation Induced by Chronic Aluminum Chloride Exposure in Rat’s Testes

Al‐Hashem¹

2009

American J. of Applied Sciences

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“…In the present report, we observed a significant increase in lipid peroxidation after AlCl 3 exposure, as measured in terms of TBARS and HP levels in the liver and kidney of the rats. These result are in agreement with many studies that also demonstrated a significant increase in TBARS and HP in the kidney, liver and the brain of rats after intoxication by aluminum salts [53,60,63,64] . The increased lipid peroxidation is due to inhibition or a change in the activity of non-enzymatic and enzymatic components of the oxidative system, i.e., GSH, SOD and CAT, in the liver and kidney.…”

Section: Discussionsupporting

confidence: 93%

“…Our results demonstrated that oral administration of AlCl 3 caused a significant increase in serum cholesterol and triglycerides, which may indicate a loss of membrane integrity, disturbance of lipid metabolism and/or liver dysfunction [52] . With regards to renal damage, biochemical findings in this study are in agreement with other studies [11,14,47,53] demonstrating that the oral administration of AlCl 3 resulted in a significant increase in serum urea and creatinine and a substantial decrease in total protein and albumin levels compared to control animals. Collectively, these findings demonstrate that accumulation of aluminum in the kidneys may promote degeneration of renal tubular cells leading to nephrotoxicity [11,14] .…”

Section: Discussionsupporting

confidence: 92%

“…Szilagyi et al [47] reported that alterations in serum urea may be related to metabolic disturbances secondary to renal dysfunction. Alternatively, Katyal et al [53] published that the increase in urea serum concentration in aluminumtreated animals may be due to aluminum-mediated changes in liver function; urea is the end product of protein catabolism. Albumin is the most abundant protein in human plasma, representing 55-65% of the total protein.…”

Section: Discussionmentioning

confidence: 99%

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Camel's Milk Protects against Aluminum Chloride-Induced Toxicity in the Liver and Kidney of White Albino Rats

Al‐Hashem¹

2009

American Journal of Biochemistry and Biotechnology

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Problem statement: Aluminum chloride (AlCl 3 ) is commonly used in daily life but it can be potentially toxic. Therefore, the present study was carried out to investigate the protective effects of camel's milk against aluminum-induced biochemical alterations and oxidative stress in the liver and kidney of white albino rats. Approach: White albino male rats (230-250 g) were divided into three groups of 10 rats: a control group treated with normal saline, the AlCl 3 -treated group and the camel's milk-AlCl 3 -treated group. The AlCl 3 treated group received 0.5 mg kg −1 of AlCl 3 orally. The camel's milk-AlCl 3 -treated group was fed 1 mL of fresh camel's milk 10 minutes prior to the administration of oral AlCl 3 . All rats were treated every day for 30 days. Liver and kidney biochemical serum parameters were analyzed. Lipid peroxidation, as determined by the tissue concentrations of thiobarbituric acid reactive substances (TBARS) and hydrogen peroxide (HP), and the oxidative stress status, as measured by glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) activity, were evaluated in the kidney and liver of treated rats. Results: Data showed that the oral administration of AlCl 3 resulted in statistically significant increases in the serum levels of urea, creatinine, bilirubin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), cholesterol and triglycerides; the total amount of protein and albumin were also significantly decreased. However, these parameters were within normal levels in the rats given camel's milk prior to AlCl 3 . Additionally, oral administration of AlCl 3 induced lipid peroxidation in the liver and kidney, which was indicated by a significant increase in lipid peroxidation biomarkers (TBARS and HP) and a significant decrease in the activities of GSH, SOD and CAT. In all rats treated with camel's milk before being given AlCl 3 , lipid peroxidation and oxidative stress parameters were within normal levels. Conclusion: Treatment with camel's milk prior to AlCl 3 exposure alleviates AlCl 3 -associated hazards and protects the kidney and liver from AlCl 3 toxicity.

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“…Our results are in agreement with other authors that a signifi cant increase in TBARs in the liver and kidney after aluminum intoxication. 21,22 This elevation of LPO in the liver and kidney was evident by the increased production of TBARS, which suggests participation of free-radical induced oxidative cell injury in mediating the toxicity of Al. 21 Abubakar et al, ascertained that even small quantities of aluminum in hepatocytes associated with an increase in ROS and peroxidation.…”

Section: Discussionmentioning

confidence: 95%

Evaluation of antioxidant effect of Salacia oblonga against aluminum chloride induced visceral toxicity in albino rats

Nathiya

Nandhini

2014

Int J Basic Clin Pharmacol

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Oral aluminum administration and oxidative injury

Cited by 40 publications

References 13 publications

Camel’s Milk Alleviates Oxidative Stress and Lipid Peroxidation Induced by Chronic Aluminum Chloride Exposure in Rat’s Testes

Camel’s Milk Alleviates Oxidative Stress and Lipid Peroxidation Induced by Chronic Aluminum Chloride Exposure in Rat’s Testes

Camel's Milk Protects against Aluminum Chloride-Induced Toxicity in the Liver and Kidney of White Albino Rats

Evaluation of antioxidant effect of Salacia oblonga against aluminum chloride induced visceral toxicity in albino rats

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