Oral administration of indigenous oxalate degrading lactic acid bacteria and quercetin prevents calcium oxalate stone formation in rats fed with oxalate rich diet

Gomathi, Sivasamy; Ponnusamy, Sasikumar; Anbazhagan, Kolandaswamy; Neha, Sarodaya Anand; Sundaresan, Sivapatham; Selvi, M. S.; Selvam, Govindan Sadasivam

doi:10.1016/j.jff.2015.05.011

Cited by 12 publications

(8 citation statements)

References 49 publications

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“…Gomathi et al . () observed that probiotic Lactobacillus strains and quercetin administered to rats significantly reduced urinary oxalate levels and oxidative stress.…”

Section: Introductionmentioning

confidence: 98%

The effects of inulin as a prebiotic supplement and the synbiotic interactions of probiotics to improve oxalate degrading activity

Darilmaz

Sönmez

Beyatlı

2018

Int J of Food Sci Tech

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This paper examines the impact of inulin, Lactobacillus spp. (candidate probiotics), and synbiotic (inulin + Lactobacillus spp.) preparation on oxalate degrading activity and viability of Escherichia coli. In this study, the lowest viability of E. coli was recorded for the synbiotic treatments of Lactobacillus fermentum BP5 (59%) and IP5 (60%). The oxalate degrading activity of L. fermentum IP5 was 38.18 and 29.60% higher than the other strains after growth in 10 mM and 20 mM MRS-ox plus 5% inulin media, respectively. The mixture of three strains demonstrated higher oxalate degrading capacity than the individual strains and showed the same good growth rates (9.43 CFU mL À1 ) as individuals. The study concludes that the addition of prebiotics has a significant effect on probiotics; therefore, a combination of L. fermentum IP5 with inulin could be a viable probiotic-based functional food approach in administering oxalate metabolism and also treatment of E. coli-related infections. Effect of prebiotic on oxalate degradation D. € Onal Darilmaz et al. the MRS-ox plus 5% inulin were found significant (P < 0.05). b Control: MRS broth (pH 6.8) without inulin and E. coli ATCC 11105. c Refrence strains. d Mixed culture: Mixed culture consist of MP1, IP5 and YG7 strains. Effect of prebiotic on oxalate degradation D. € Onal Darilmaz et al. 125 a Values are means AE standard deviations from experimenst done in triplicate. Differences in MRS-ox and MRS-ox plus 5% inulin for degrading activity were found to be significant (P < 0.05). b Control: MRS (pH 6.8) (Without sodium oxalate and inulin). c Refrence strains. d Mixed culture: Mixed culture consist of MP1, IP5 and YG7 strains. Effect of prebiotic on oxalate degradation D. € Onal Darilmaz et al. to be significant (P < 0.05). b Control: MRS (pH 6.8) (Without sodium oxalate and inulin). c Refrence strains. d Mixed culture: Mixed culture consist of MP1, IP5 and YG7 strains. Effect of prebiotic on oxalate degradation D. € Onal Darilmaz et al. Effect of prebiotic on oxalate degradation D. € Onal Darilmaz et al.

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“…Gomathi et al . () observed that probiotic Lactobacillus strains and quercetin administered to rats significantly reduced urinary oxalate levels and oxidative stress.…”

Section: Introductionmentioning

confidence: 98%

The effects of inulin as a prebiotic supplement and the synbiotic interactions of probiotics to improve oxalate degrading activity

Darilmaz

Sönmez

Beyatlı

2018

Int J of Food Sci Tech

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“…Lollo et al (2015b) showed that regular consumption of probiotic Minas Frescal cheese exerted a prophylactic effect against hypertension, and significant effect on renal function parameters could occur over a longer experimental period. Gomathi et al (2015) observed that probiotic Lactobacillus strains and quercetin administered to rats significantly reduced urinary oxalate levels and oxidative stress. In another study conducted by Akoglu et al (2015), Lactobacillus casei Shirota administration twice a day in patients with acute gastroenteritis showed significant effects in the reduction of bowel movements and positive effects on kidney function and inflammation.…”

Section: Introductionmentioning

confidence: 95%

“…Gomathi et al . () observed that probiotic Lactobacillus strains and quercetin administered to rats significantly reduced urinary oxalate levels and oxidative stress. In another study conducted by Akoglu et al .…”

Section: Introductionmentioning

confidence: 98%

Determination of the relationship between oxalate degradation and exopolysaccharide production by different Lactobacillus probiotic strains

Sönmez¹,

Darilmaz

Beyatlı³

2018

Int J of Dairy Tech

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The aim of this study was to evaluate the protective effects of exopolysaccharide (EPS) production on resistance to gastrointestinal digestive conditions and oxalate by probiotic strains of the species Lactobacillus rhamnosus, Lactobacillus fermentum and Lactobacillus brevis. The oxalate‐degrading ability of the strains was determined using an enzymatic assay. The correlation between oxalate degradation rate and EPS production was not significant (P > 0.05); however, the high‐EPS‐producing L. fermentumIP5 and L. brevisYG7 strains showed high oxalate‐degrading activity, whereas the low‐EPS‐producing strain L. fermentumBP5 demonstrated low oxalate‐degrading activity. The present findings suggest that dietary supplementation with the probiotic strain L. fermentumIP5 could be a promising strategy for the prevention of oxalate stone disease.

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“…Several researchers have reported, in vitro, the effect of catechin, resveratrol, epicatechin, hesperidin, hesperitin, and quercetin on the prevention of urolithiasis formation, using crystallization processes, artificial urine, and crystal development in cellular assays [10][11][12]16,[18][19][20][21][22][23][24].…”

Section: In Vitro Investigationsmentioning

confidence: 99%

“…In vitro: renal tubular cell injury induced by oxalate (MDCK cells) at doses 0, 25, 50, and 100 µM In vivo: sodium oxalate (3%) induced urinary crystal deposit formation for 4 weeks Quercetin at 10 mg/kg daily for 4 weeks Increased the cell viability and prevented lipid peroxidation Decreased malondialdehyde levels Increased catalase and superoxide dismutase activity Decreased significantly the number of crystals in kidneys [20] Hyperoxaluria induced by potassium oxalate diet Quercetin at 10 mg/kg daily from 15 to 28 days Altered the increased lipid peroxidation and antioxidant depletion as compared with rats fed with KOx Reduced CaOx aggregation in urine and kidneys Altered the expression of CaOx modulator genes and antioxidant genes (GPx and SOD) [23] Nephrolithiasis induced by ethylene glycol (0.75%) Dose: 2 mg/kg daily for 28 days Increased urine volume Decreased the size of calculi Enhanced the excretion of calcium, oxalate, and phosphate, and increased the levels of magnesium Reduced the levels of BUN and creatinine [24]…”

Section: Catechinmentioning

confidence: 99%

Litholytic Activities of Natural Bioactive Compounds and Their Mechanism Insights

et al. 2021

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Urolithiasis is a disease characterized by the formation of stones, which are crystalline accretions that form in the urinary tract from minerals dissolved in the urine. Moreover, it is considered to be a complex and multifactorial disease, requiring treatment. Unfortunately, current treatments are insufficient or may induce several side effects. In fact, medicinal plants are among the anti-litholytic treatments that are strongly recommended by many studies. Indeed, these natural resources contain bioactive molecules of different natures, such as flavonoids, terpenoids, alkaloids, and phenolic acids, which have recently demonstrated very important anti-litholytic effects. The molecular mechanisms involved are multiple and variable, and can reach cellular and molecular levels. In this review, we have discussed in depth the work that has studied the bioactive molecules of medicinal plants and their major potential against urolithiasis. Scientific databases, including Web of Science, PubMed, and Google Scholar, were searched from their inception until April 2021.The cellular and molecular mechanisms are presented and discussed. Some mechanisms of action related to these bioactive compounds are highlighted. This review could provide a scientific starting point for further studies on urolithiasis and natural bioactive compounds, especially flavonoids.

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Oral administration of indigenous oxalate degrading lactic acid bacteria and quercetin prevents calcium oxalate stone formation in rats fed with oxalate rich diet

Cited by 12 publications

References 49 publications

The effects of inulin as a prebiotic supplement and the synbiotic interactions of probiotics to improve oxalate degrading activity

The effects of inulin as a prebiotic supplement and the synbiotic interactions of probiotics to improve oxalate degrading activity

Determination of the relationship between oxalate degradation and exopolysaccharide production by different Lactobacillus probiotic strains

Litholytic Activities of Natural Bioactive Compounds and Their Mechanism Insights

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