Optofluidic microsystems for chemical and biological analysis

Fan, Xudong; White, Ian M.

doi:10.1038/nphoton.2011.206

Cited by 812 publications

(543 citation statements)

References 98 publications

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“…Another application lies in chemical and biological sensing, particularly in optofluidic setups 226 . One sensing mechanism uses the shift of resonance frequency to detect the change of refractive index in the surroundings.…”

Section: Applications Of Bics and Quasi-bicsmentioning

confidence: 99%

Bound states in the continuum

et al. 2016

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Bound states in the continuum are waves that, defying conventional wisdom, remain localized even though they coexist with a continuous spectrum of radiating waves that can carry energy away. Their existence was first proposed in quantum mechanics and, being a general wave phenomenon, later identified in electromagnetic, acoustic, and water waves. They have been studied in a wide variety of material systems such as photonic crystals, optical waveguides and fibers, piezoelectric materials, quantum dots, graphene, and topological insulators. This Review describes recent developments in this field with an emphasis on the physical mechanisms that lead to these unusual states across the seemingly very different platforms. We discuss recent experimental realizations, existing applications, and directions for future work.

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Section: Applications Of Bics and Quasi-bicsmentioning

confidence: 99%

Bound states in the continuum

et al. 2016

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“…Certain conventional microfabrication technologies, such as soft [4][5][6] or UV lithography, 7 have been used to integrate two-dimensional (2D) microoptical devices, including optical waveguides, microring resonators, and distributed feedback dye lasers, with microfluidics. [2][3][4][5][6][7][8] These optofluidic chips afford a wide range of applications in light propagation, wavelength tuning and microfluidic lasing. The integration of three-dimensional (3D) optical micro/ nanostructures has further advanced the functionalization of optofluidic devices.…”

Section: Introductionmentioning

confidence: 99%

In-channel integration of designable microoptical devices using flat scaffold-supported femtosecond-laser microfabrication for coupling-free optofluidic cell counting

Niu

et al. 2015

Light Sci Appl

118

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The high-precision integration of three-dimensional (3D) microoptical components into microfluidics in a customizable manner is crucial for optical sensing, fluorescence analysis, and cell detection in optofluidic applications; however, it remains challenging for current microfabrication technologies. This paper reports the in-channel integration of flexible two-dimensional (2D) and 3D polymer microoptical devices into glass microfluidics by developing a novel technique: flat scaffold-supported hybrid femtosecond laser microfabrication (FSS-HFLM). The scaffold with an optimal thickness of 1-5 mm is fabricated on the lower internal surface of a microfluidic channel to improve the integration of high-precision microoptical devices on the scaffold by eliminating any undulated internal channel surface caused by wet etching. As a proof of demonstration, two types of typical microoptical devices, namely, 2D Fresnel zone plates (FZPs) and 3D refractive microlens arrays (MLAs), are integrated. These devices exhibit multicolor focal spots, elongated (.three times) focal length and imaging of the characters 'RIKEN' in a liquid channel. The resulting optofluidic chips are further used for coupling-free white-light cell counting with a success rate as high as 93%. An optofluidic system with two MLAs and a W-filter is also designed and fabricated for more advanced cell filtering/counting applications.

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“…Recent developments in optofluidic cell analysis techniques include optical fibers [18] and on-chip waveguides [19,20], integrated into microfluidic systems so as to create embedded optical traps. There have also been several reports of optical propulsion of cells along waveguides.…”

Section: Biophotonicsmentioning

confidence: 99%

Long‐distance laser propulsion and deformation‐ monitoring of cells in optofluidic photonic crystal fiber

Unterkofler

Garbos

Euser

et al. 2012

Journal of Biophotonics

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We introduce a unique method for laser‐propelling individual cells over distances of 10s of cm through stationary liquid in a microfluidic channel. This is achieved by using liquid‐filled hollow‐core photonic crystal fiber (HC‐PCF). HC‐PCF provides low‐loss light guidance in a well‐defined single mode, resulting in highly uniform optical trapping and propulsive forces in the core which at the same time acts as a microfluidic channel. Cells are trapped laterally at the center of the core, typically several microns away from the glass interface, which eliminates adherence effects and external perturbations. During propagation, the velocity of the cells is conveniently monitored using a non‐imaging Doppler velocimetry technique. Dynamic changes in velocity at constant optical powers up to 350 mW indicate stress‐induced changes in the shape of the cells, which is confirmed by bright‐field microscopy. Our results suggest that HC‐PCF will be useful as a new tool for the study of single‐cell biomechanics. (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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Optofluidic microsystems for chemical and biological analysis

Cited by 812 publications

References 98 publications

Bound states in the continuum

Bound states in the continuum

In-channel integration of designable microoptical devices using flat scaffold-supported femtosecond-laser microfabrication for coupling-free optofluidic cell counting

Long‐distance laser propulsion and deformation‐ monitoring of cells in optofluidic photonic crystal fiber

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