Optimizing nanoencapsulation of Heracleum lasiopetalum by response surface methodology

Abstract

This study was carried out to optimize formulation for Heracleum lasiopetalum (golpar) extract nanoencapsulation by response surface methodology (RSM). The primary water-in-oil emulsion was fabricated by (5%-10%) golpar extract (GE), (40%-35%) emulsifier span 80 (EM), and (50%-60%) sunflower oil (SO). The coating materials were the mixture of Lepidium sativum seed gum (LSG) and whey protein concentrate (WPC) at different ratios (1:0, 1:1, and 0:1). The yield of nanoencapsulation of GE, particle size, and zeta potential was investigated as responses of RSM. The optimal formulation for water-in-oil-in-water emulsion of GE were SO: 50.46%, GE 9.52%, and EM: 36.30% in LSG, SO: 57.07%, GE: 7.12%, and EM: 30.85% in LSG:WPC, and SO: 54.98%, GE: 9.05%, and EM: 39.87% in WPC coating. In conclusion, the nanoencapsulation of GE prepared with the optimized formulation by RSM ensures the gradual release and higher stability to sedimentation during storage with nanometric size and high yield of encapsulation. The nanocapsules of GE can be used as a natural antioxidant in food systems.

Evaluation of the Protective and Healing Effects of Heracleum lasiopetalum Boiss on a Modified Acetic Acid-Induced Ulcerative Colitis Model in Rats

“…Heracleum lasiopetalum (Golpar-e barfi), a plant belonging to the Umbrella family, is found in the humid mountainous areas of Iran, Turkey, and Iraq. In Iranian traditional healing practices, Heracleum lasiopetalum serves various purposes, including its role as an antiseptic, spice, carminative, aid to digestion, flavor enhancer, and food supplement (14). Additionally, several studies have reported the anti-Candida, antibacterial, and antioxidant effects of Heracleum lasiopetalum (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25).…”