“…The main research gap with respect to the milk-run design problem is the lack of an explicit, deterministic model representing inventory behavior in the case of cyclically repeated delivery profile schedules with levelled lot sizes. Furthermore, the literature offers no operational model that would simultaneously take into account transport concept assignment, frequency assignment, and the milk-run scheduling decision [13,17,23,24]. Milk-run problems of component/part/commodity distribution can be classified similarly to the exhaustively studied extensions of the VRP, such as the capacitated and consistent VRP with multi-trip multi-traffic pick-up and delivery problem with time windows and synchronization which is a combination of variants of the VRP with multiple trips, VRP with time windows, and capacitated routing and delivery problem [7,13,22,23,25,26].…”