Optimized Synthesis of Biodegradable Elastomer PEGylated Poly(glycerol sebacate) and Their Biomedical Application

Abstract

Poly(glycerol sebacate) (PGS), a biodegradable elastomer, has been extensively explored in biomedical applications for its favorable mechanical properties and biocompatibility. Efforts have been made to fabricate multifunctional PGS copolymer in recent years, in particular PGS-co-PEG (poly(glycerol sebacate)-co-polyethylene glycol) polymers. However, rare research has been systematically conducted on the effect of reactant ratios on physicochemical properties and biocompatibility of PGS copolymer till now. In this study, a serial of PEGylated PGS (PEGS) with PEG content from 20% to 40% and carboxyl to hydroxyl from 0.67 to 2 were synthesized by thermal curing process. The effects of various PEGS on the mechanical strength and biological activity were further compared and optimized. The results showed that the PEGS elastomers around 20PEGS-1.0C/H and 40PEGS-1.5C/H exhibited the desirable hydrophilicity, degradation behaviors, mechanical properties and cell viability. Subsequently, the potential applications of the 20PEGS-1.0C/H and 40PEGS-1.5C/H in bone repair scaffold and vascular reconstruction were investigated and the results showed that 20PEGS-1.0C/H and 40PEGS-1.5C/H could significantly improve the mechanical strength for the calcium phosphate scaffolds and exhibited preferable molding capability for fabrication of the vascular substitute. These results confirmed that the optimized PEGS elastomers should be promising multifunctional substrates in biomedical applications.

Exosomes: A Novel Therapeutic Agent for Cartilage and Bone Tissue Regeneration

“…These materials better support the mechanical requirements of initial implantation and they also provide desirable releasing profiles of bioactive factors. [63][64][65][66] According to recent studies, exosomes have been identified as a novel and effective therapy for skeletal tissue repair. Unfortunately, the common mode of administration for therapeutic exosomes was primarily through injection, in which therapeutic exosomes were unable to be retained at the desired site because they were inevitably rapidly cleared.…”

Recapitulation of In Situ Endochondral Ossification Using an Injectable Hypoxia‐Mimetic Hydrogel

“…Because of its tunable mechanical properties and remarkable biocompatibility, biodegradable elastomer poly(glycerol sebacate)-co-poly(ethylene glycol) (PEGS) has been widely used for various applications in tissue regeneration. [22][23][24][25] Specifically, our group previously found that the viscoelastic PEGS was beneficial to chondrocyte growth and extracellular matrix secretion and thus enhanced cartilage formation during bone regeneration. [26,27] Based on the above rationale, in this study, we endeavored to develop a novel injectable PAA-modified PEGS hydrogel (PEGS/PAA) to induce a hypoxia-based ECO for bone regeneration (Scheme 1B).…”

Targeting Approaches of Nanomedicines in Acute Myeloid Leukemia

“…With advantages of biocompatible, tailored release, prolonging circulation, and functionalizing with specific peptide targeting ligands or antibodies, polymers have been the most intensively explored materials in drug delivery systems. 86 -88…”

“…With advantages of biocompatible, tailored release, prolonging circulation, and functionalizing with specific peptide targeting ligands or antibodies, polymers have been the most intensively explored materials in drug delivery systems. [86][87][88] Polymeric NPs could conjugate hydrophobic drugs by encapsulating to solid cores or water-soluble drugs by covalently attaching, which could control drug release, prolong circulation time, or reduce toxicity. [89][90][91][92] Polylactide (PLA) and poly(lactide-co-glycolide) (PLGA) are commonly used polymers at present.…”