Optimized Extraction, Preliminary Characterization and Evaluation of the in Vitro Anticancer Activity of Phlorotannin-Rich Fraction from the Brown Seaweed, <i>Cystoseira sedoides</i>

Abdelhamid, Amal; Lajili, Sirine; Elkaibi, Mohamed Amine; Salem, Yosra Ben; Abdelhamid, Ameni; Muller, Christian D.; Majdoub, Hatem; Kraı̈em, Jamil; Bouraoui, Abderrahman

doi:10.1080/10498850.2019.1662865

Cited by 27 publications

(19 citation statements)

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“…To overcome such problems, several researchers tested a mixture of water and ethanol in different mixing ratios. Several studies optimized the extraction parameters using statistical models, so that they could get the maximum polyphenol compounds with a possible combination of extraction parameters [ 26 , 27 , 61 , 62 , 63 , 64 ].…”

Section: Emerging Technologies For Extraction Of Marine Phenolicsmentioning

confidence: 99%

Emerging Technologies for the Extraction of Marine Phenolics: Opportunities and Challenges

2020

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Natural phenolic compounds are important classes of plant, microorganism, and algal secondary metabolites. They have well-documented beneficial biological activities. The marine environment is less explored than other environments but have huge potential for the discovery of new unique compounds with potential applications in, e.g., food, cosmetics, and pharmaceutical industries. To survive in a very harsh and challenging environment, marine organisms like several seaweed (macroalgae) species produce and accumulate several secondary metabolites, including marine phenolics in the cells. Traditionally, these compounds were extracted from their sample matrix using organic solvents. This conventional extraction method had several drawbacks such as a long extraction time, low extraction yield, co-extraction of other compounds, and usage of a huge volume of one or more organic solvents, which consequently results in environmental pollution. To mitigate these drawbacks, newly emerging technologies, such as enzyme-assisted extraction (EAE), microwave-assisted extraction (MAE), ultrasound-assisted extraction (UAE), pressurized liquid extraction (PLE), and supercritical fluid extraction (SFE) have received huge interest from researchers around the world. Therefore, in this review, the most recent and emerging technologies are discussed for the extraction of marine phenolic compounds of interest for their antioxidant and other bioactivity in, e.g., cosmetic and food industry. Moreover, the opportunities and the bottleneck for upscaling of these technologies are also presented.

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Section: Emerging Technologies For Extraction Of Marine Phenolicsmentioning

confidence: 99%

Emerging Technologies for the Extraction of Marine Phenolics: Opportunities and Challenges

2020

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“…Using water as extraction solvent a most efficient extraction process with shorter processing times and a higher purity product was obtained [ 185 ]. The same compounds were also attained from the brown seaweed C. sedoides [ 186 ].…”

Section: Novel Liquid–liquid and Solid–liquid Extraction Technologmentioning

confidence: 91%

Macroalgae as a Source of Valuable Antimicrobial Compounds: Extraction and Applications

et al. 2020

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In the last few decades, attention on new natural antimicrobial compounds has arisen due to a change in consumer preferences and the increase in the number of resistant microorganisms. Macroalgae play a special role in the pursuit of new active molecules as they have been traditionally consumed and are known for their chemical and nutritional composition and their biological properties, including antimicrobial activity. Among the bioactive molecules of algae, proteins and peptides, polysaccharides, polyphenols, polyunsaturated fatty acids and pigments can be highlighted. However, for the complete obtaining and incorporation of these molecules, it is essential to achieve easy, profitable and sustainable recovery of these compounds. For this purpose, novel liquid–liquid and solid–liquid extraction techniques have been studied, such as supercritical, ultrasound, microwave, enzymatic, high pressure, accelerated solvent and intensity pulsed electric fields extraction techniques. Moreover, different applications have been proposed for these compounds, such as preservatives in the food or cosmetic industries, as antibiotics in the pharmaceutical industry, as antibiofilm, antifouling, coating in active packaging, prebiotics or in nanoparticles. This review presents the main antimicrobial potential of macroalgae, their specific bioactive compounds and novel green extraction technologies to efficiently extract them, with emphasis on the antibacterial and antifungal data and their applications.

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“…One of the most common mechanisms responsible for phlorotannins anti-proliferative activity is their capacity to interact with multiple mediators of the apoptotic signaling cascade and thus trigger cell death by inducing apoptosis [ 115 , 116 , 130 , 131 , 133 ]. In this context, a hydrophilic fraction obtained from F. vesiculosus acetone extract was shown to induce apoptosis in different pancreatic cell lines through cell cycle arrest, which is comparable to the effects of common chemotherapeutic drugs clinically used, such as gemcitabine [ 120 ].…”

Section: The Contribution Of Phlorotanninsmentioning

confidence: 99%

Brown Algae Phlorotannins: A Marine Alternative to Break the Oxidative Stress, Inflammation and Cancer Network

Catarino

Amarante

Mateus

et al. 2021

Foods

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According to the WHO, cancer was responsible for an estimated 9.6 million deaths in 2018, making it the second global leading cause of death. The main risk factors that lead to the development of this disease include poor behavioral and dietary habits, such as tobacco use, alcohol use and lack of fruit and vegetable intake, or physical inactivity. In turn, it is well known that polyphenols are deeply implicated with the lower rates of cancer in populations that consume high levels of plant derived foods. In this field, phlorotannins have been under the spotlight in recent years since they have shown exceptional bioactive properties, with great interest for application in food and pharmaceutical industries. Among their multiple bioactive properties, phlorotannins have revealed the capacity to interfere with several biochemical mechanisms that regulate oxidative stress, inflammation and tumorigenesis, which are central aspects in the pathogenesis of cancer. This versatility and ability to act either directly or indirectly at different stages and mechanisms of cancer growth make these compounds highly appealing for the development of new therapeutical strategies to address this world scourge. The present manuscript revises relevant studies focusing the effects of phlorotannins to counteract the oxidative stress–inflammation network, emphasizing their potential for application in cancer prevention and/or treatment.

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Optimized Extraction, Preliminary Characterization and Evaluation of the in Vitro Anticancer Activity of Phlorotannin-Rich Fraction from the Brown Seaweed, Cystoseira sedoides

Cited by 27 publications

References 50 publications

Emerging Technologies for the Extraction of Marine Phenolics: Opportunities and Challenges

Emerging Technologies for the Extraction of Marine Phenolics: Opportunities and Challenges

Macroalgae as a Source of Valuable Antimicrobial Compounds: Extraction and Applications

Brown Algae Phlorotannins: A Marine Alternative to Break the Oxidative Stress, Inflammation and Cancer Network

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