2013
DOI: 10.1167/iovs.13-12664
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Abstract: Ceragenin CSA-138 appears well suited for providing an innate immune-like function to abiotic hydrogel contact lenses for extended periods of time. Elution of even low concentrations of CSA-138 (<0.5 μg) is sufficient to eliminate inocula of 10⁶ CFU of S. aureus and P. aeruginosa.

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Cited by 35 publications
(24 citation statements)
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“…No adverse events were observed, while bacterial counts were decreased dramatically. Similarly, studies involving medical devices [26,94] and bone regrowth [28] demonstrated no toxicity or local cytotoxicity, suggesting that in these venues ceragenins are well tolerated. Considering potential applications of ceragenins, it is likely that they will find use in localized fashion (e.g., topical treatment for infection) and in specific tissues.…”
Section: Discussionmentioning
confidence: 93%
See 1 more Smart Citation
“…No adverse events were observed, while bacterial counts were decreased dramatically. Similarly, studies involving medical devices [26,94] and bone regrowth [28] demonstrated no toxicity or local cytotoxicity, suggesting that in these venues ceragenins are well tolerated. Considering potential applications of ceragenins, it is likely that they will find use in localized fashion (e.g., topical treatment for infection) and in specific tissues.…”
Section: Discussionmentioning
confidence: 93%
“…Ceragenins offer an attractive alternative, in part due to their antimicrobial activities, relatively low cost and stability; additionally, in the specific context of contact lens manufacture, ceragenins offer these attributes: colorless nature of ceragenins, their solubility in the pre-polymers used to produce lenses, their lack of interference in polymerization processes used in lens formation and the thermal stability of ceragenins, allowing autoclaving of finished products [93,94]. Gu et al [94] reported that adding an acrylamide group to a ceragenin, giving CSA-120 (Figure 4), allow it to participate in the radical reaction leading to lens formation, thus covalently attaching the ceragenin to the contact lens. With CSA-120 present as 1.25% of the dry mass of the lens, bacterial biofilm formation was decreased by three logs over 24 hours incubation, when tested in a 10% nutrient medium.…”
Section: Incorporation Of Ceragenins Into Contact Lensesmentioning
confidence: 99%
“…Biofilms of certain species, including Candida , P. aeruginosa , and Fusarium , are resistant to the biocides in standard contact lens solutions but are susceptible to hydrogen peroxide [98]. However, contact lenses made from hydrogels that release ceragenin are reportedly capable of resisting colonization by P. aeruginosa and S. aureus for two and four weeks, respectively [99]. …”
Section: Biofilm Formation and Biofoulingmentioning
confidence: 99%
“…Manyetik yüzeylere bağlanarak oluşturulan bu nanopartiküller hem teşhis hem de tedavi için kullanılabilecek multifonksiyonel formlardır (19,35) . Serageninlerin antibakteriyel etkide doğal immün fonksiyona sahip hidrojel kontakt lensler (17) yada perioperatif cihazla ilişkili infeksiyonlarda kullanılan polimerik kaplı formlar (40) gibi farklı uygulama alanları bulunmaktadır.…”
Section: -Csa'ların In Vitro Etki Spektrumuunclassified