Optimization of calcium pectinate gel beads for sustained-release of catechin using response surface methodology

Lee, Ji Soo; Chung, Donghwa; Lee, Hyeon Gyu

doi:10.1016/j.ijbiomac.2008.01.003

Cited by 24 publications

(1 citation statement)

References 32 publications

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“…Loading catechins, mostly EGCG, into a biopolymer vehicle is one way to protect them from GIT instability and for the sustained-delivery of catechins. However, the biopolymer vehicle candidate must pass several criteria, such as biocompatibility, toxicity, physical-mechanical properties and acid-environment characteristics [14].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Gelatin-γ-Polyglutamic Acid-Based Hydrogel for the In Vitro Controlled Release of Epigallocatechin Gallate (EGCG) from Camellia sinensis

et al. 2013

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Abstract:The antioxidant property and other health benefits of the most abundant catechin, epigallocatechin gallate (EGCG), are limited because of poor stability and permeability across intestine. Protecting the EGCG from the harsh gastrointestinal tract (GIT) environment can help to increase its bioavailability following oral administration. In this study, EGCG was loaded to hydrogel prepared from ionic interaction between an optimized concentration of gelatin and γ-polyglutamic acid (γ-PGA), with ethylcarbodiimide (EDC) as the crosslinker. Physicochemical characterization of hydrogel was done using Fourier transform-infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). The dependence of the swelling degree (SD) of the hydrogel to the amount of gelatin, γ-PGA, EDC, swelling time and pH was determined. A high SD of the crosslinked hydrogel was noted at pH 4.5, 6.8 OPEN ACCESSPolymers 2014, 6 40 and 9.0 compared to pH 7.4, which describes pH-responsiveness. Approximately 67% of the EGCG from the prepared solution was loaded to the hydrogel after 12 h post-loading, in which loading efficiency was related to the amount of EDC. The in vitro release profile of EGCG at pH 1.2, 6.8 and 7.4, simulating GIT conditions, resulted in different sustained release curves. Wherein, the released EGCG was not degraded instantly compared to free-EGCG at controlled temperature of 37 °C at different pH monitored against time. Therefore, this study proves the potential of pH-responsive gelatin-γ-PGA-based hydrogel as a biopolymer vehicle to deliver EGCG.

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Section: Introductionmentioning

confidence: 99%

Synthesis of Gelatin-γ-Polyglutamic Acid-Based Hydrogel for the In Vitro Controlled Release of Epigallocatechin Gallate (EGCG) from Camellia sinensis

et al. 2013

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Aceclofenac‐Loaded Plantago ovata F. Husk Mucilage‐Zn⁺²‐Pectinate Controlled‐Release Matrices

et al. 2017

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The current study is aimed at developing Plantago ovata F. husk mucilage (PHM)‐blended Zn2+‐crosslinked low methoxyl (LM) pectinate (PHM‐Zn2+‐LM‐pectinate) controlled‐release matrices containing aceclofenac (ACF) for the management of rheumatoid arthritis (RA) in patients with an outright zinc deficiency. The ACF‐encapsulated hydrogel matrices are accomplished by ionic gelation using ZnSO4 as a crosslinker. The matrix diameter ranges from 1.39 ± 0.14 to 1.62 ± 0.16 mm. These formulations demonstrate excellent drug encapsulation efficiency (DEE, 63.80 ± 1.73–90.56 ± 2.72%) and controlled drug‐release behavior over a prolonged period of time (Q10 h, 51.42 ± 3.10 to 92.60 ± 2.38%). The drug‐elution patterns of different matrices are best‐fitted by a zero‐order kinetic model with a case‐II‐transport‐driven mechanism. The matrices also depict pH‐dependent swelling and degradation properties. In addition, the composites are characterized by scanning electron microscopy (SEM), Fourier transform IR (FTIR), and powder X‐ray diffraction (P‐XRD) analyses. Thus, the newly developed PHM‐Zn+2‐LM‐pectinate matrices could be appropriate for controlled ACF delivery along with Zn supplementation in the effective treatment of RA.

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Ionically Gelled Pectinates in Drug Delivery

Nayak¹,

Hasnain²,

Pal

2021

Ionically Gelled Biopolysaccharide Based Systems in Drug Delivery

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Optimization of calcium pectinate gel beads for sustained-release of catechin using response surface methodology

Cited by 24 publications

References 32 publications

Synthesis of Gelatin-γ-Polyglutamic Acid-Based Hydrogel for the In Vitro Controlled Release of Epigallocatechin Gallate (EGCG) from Camellia sinensis

Synthesis of Gelatin-γ-Polyglutamic Acid-Based Hydrogel for the In Vitro Controlled Release of Epigallocatechin Gallate (EGCG) from Camellia sinensis

Aceclofenac‐Loaded Plantago ovata F. Husk Mucilage‐Zn⁺²‐Pectinate Controlled‐Release Matrices

Ionically Gelled Pectinates in Drug Delivery

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Optimization of calcium pectinate gel beads for sustained-release of catechin using response surface methodology

Cited by 24 publications

References 32 publications

Synthesis of Gelatin-γ-Polyglutamic Acid-Based Hydrogel for the In Vitro Controlled Release of Epigallocatechin Gallate (EGCG) from Camellia sinensis

Synthesis of Gelatin-γ-Polyglutamic Acid-Based Hydrogel for the In Vitro Controlled Release of Epigallocatechin Gallate (EGCG) from Camellia sinensis

Aceclofenac‐Loaded Plantago ovata F. Husk Mucilage‐Zn+2‐Pectinate Controlled‐Release Matrices

Ionically Gelled Pectinates in Drug Delivery

Contact Info

Product

Resources

About

Aceclofenac‐Loaded Plantago ovata F. Husk Mucilage‐Zn⁺²‐Pectinate Controlled‐Release Matrices