Journal of Chromatography A 2012 DOI: 10.1016/j.chroma.2012.01.057 View full text
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Monzure-Khoda Kazi, Bijan Medi, Mohammad Amanullah

Abstract: This work addresses optimization of an improved single-column chromatographic (ISCC) process for the separation of guaifenesin enantiomers. Conventional feed injection and fraction collection systems have been replaced with customized components facilitating simultaneous separation and online monitoring with the ultimate objective of application of an optimizing controller. Injection volume, cycle time, desorbent flow rate, feed concentration, and three cut intervals are considered as decision variables. A mul…

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