Optimization, characterization and in vitro evaluation of curcumin microemulsions

Bergonzi, Maria Camilla; Hamdouch, R.; Mazzacuva, Francesca; Isacchi, Benedetta; Bilia, Anna Rita

doi:10.1016/j.lwt.2014.06.009

Cited by 88 publications

(53 citation statements)

References 24 publications

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“…10,11) Many approaches that can be used for the enhancement of curcumin bioavailability such as encapsulation, use excipient foods, emulsions, and/or micelles. [12][13][14] An alternative approach that suggested enhancing the bioavailability of curcumin is to develop a curcumin-metal complex. The use of metals in therapeutic drugs offers a large extent of exciting and valuable metallo-pharmaceutical drugs like Cisplatin and Auranfin as anticancer and antiarthritic drugs, respectively.…”

mentioning

confidence: 99%

“…13) Zn was known by its mimetic actions which enforced exploration of the antidiabetic properties of Zn complexes. 14,15) In the present study, we have designed, synthesized, and characterized a curcumin-Zn complex using safe, reproductive and efficient procedures. Comparable evaluation of the antidiabetic potentials of curcumin, Zn, and curcumin-Zn complex was explored.…”

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confidence: 99%

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Dual Effect of Curcumin–Zinc Complex in Controlling Diabetes Mellitus in Experimentally Induced Diabetic Rats

Al-Ali

Fatah

El‐Badry

2016

Biological & Pharmaceutical Bulletin

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Ultrasound-assisted extraction of curcumin from Curcuma longa was performed in an ultrasonic bath at 30°C using ethanol for 40 min. A successful attempt has been made to prepare curcumin-zinc (Zn) complex using a simple chemical procedure. The complex formation and its stoichiometry were characterized using elemental analysis, Fourier transform (FT)-IR and UV spectroscopy which revealed the interaction of Zn(II) ion (M) with curcumin (ligand, L) to proceed via (ML) complex type formation. Oral administration of curcumin-Zn complex at a concentration of 150 mg/kg body weight/rat/d for 45 d in streptozotocin-induced diabetic rats in comparison to curcumin and/or Zn administration exerted a hypoglycemic effect. A significant reduction in blood glucose, glycosylated hemoglobin (Hb)A1c, and lipid profile parameters with an excellent improvement in plasma insulin levels have been attained. Also, the reduced activities of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, and creatinine in the diabetic rats treated with the complex exhibited the non-toxic nature of the curcumin-Zn complex. Finally, the larger extent of the complex in hyperglycemic improvement in comparison to curcumin and/or Zn supplementation was interpreted by its dual action on glucose and insulin maintenance.Key words diabetes; curcumin-zinc complex; dual action; curcumin; zinc metal; diabetes complication Diabetes mellitus, the most common endocrine disorder characterized by a state of chronic hyperglycemia and insulin resistance. Type 2 Diabetes Mellitus (T2DM) is projected to rise over 215 million people worldwide by the year 2010.

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confidence: 99%

mentioning

confidence: 99%

Dual Effect of Curcumin–Zinc Complex in Controlling Diabetes Mellitus in Experimentally Induced Diabetic Rats

Al-Ali

Fatah

El‐Badry

2016

Biological & Pharmaceutical Bulletin

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“…This is probably due to the interaction of the loaded active compound or solubilizing agent with the surfactant layer. However, the average size of the xanthone-incorporated microemulsion was less than 150 nm, which is a satisfactory result for the microemulsion systems [23,24]. Table 2 demonstrates that the viscosity of the xanthone-loaded microemulsion-based gel using carbopol aqua SF-1 at a concentration of 15% was about the same as that using carbopol ETD 2020 at a concentration of 1.5% with Eta values around 24 Pas.…”

Section: Solubility Test Of Xanthonementioning

confidence: 76%

Preparation, Characterization and Antioxidant Activity of Xanthone-Loaded Making (Hodgsonia Heteroclita) Microemulsions

Chansakaow

Sirisa-ard

Khonkarn

2017

Int J Pharm Pharm Sci

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Objective: The aim of this study was to incorporate xanthone into Making (Hodgsonia heteroclita) microemulsions and to evaluate the antioxidant activity of the formulations. Methods:Making oil was obtained from the seed of Hodgsonia heteroclite by a screw press machine. The solubility of xanthone in various oils, surfactants, and co-surfactants was investigated. Stable Making microemulsion and microemulsion-based gel were simultaneously loaded with xanthone. Finally, an in vitro xanthone release study was carried out and antioxidant activity was determined. Results:The optimal formulations of the Making microemulsion consisted of Making oil, capryol 90, tween 80, propylene glycol, and water. The average droplet size of xanthone-loaded Making microemulsion was around 110-130 nm. It was found that the stability of the xanthone-loaded Making microemulsion-based gel was higher than the xanthone-loaded Making microemulsion. Besides, the release of xanthone from the Making microemulsion-based gel was lower than that of the Making microemulsion. Moreover, it was found that the antioxidant activity of both xanthoneloaded Making microemulsion (TEAC and EC values of 9.8 mmol/mg and 14.8 mmol/mg, respectively) and microemulsion-based gel (TEAC and EC values of 9.4 mmol/mg and 18.5 mmol/mg, respectively) remained high even after extended storage conditions. Conclusion:It was concluded that Making oil is an attractive material to deliver xanthone in pharmaceutical applications.

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“…Three microemulsions were developed and characterized, stabilized by non-ionic surfactants Cremophor EL, Tween 20, Tween 80, or lecithin and contained a variety of oils, namely, olive oil, wheat germ oil, and vitamin E. The oral absorption of curcumin microemulsions was investigated in vitro using PAMPA. The optimal formulation consisted of vitamin E (3.3 g/100 g), Tween 20 (53.8 g/100 g), ethanol (6.6 g/100 g), and water (36.3 g/ 100 g), obtaining a percentage of permeation through the artificial membrane of about 70 % [49]. Dendrosomal curcumin, a polymeric micelle of 142 nm with constant physical and chemical stability, synthesized by esterification of oleoyl chloride (0.01 mol) and polyethylene glycol 400 (0.01 mol) was developed and tested for the inhibition on the proliferation of U87MG cells, a cellular model of glioblastoma.…”

Section: Curcumin-loaded Nanoparticles: Increased Efficacy Of a Plethmentioning

confidence: 99%

Improving on Nature: The Role of Nanomedicine in the Development of Clinical Natural Drugs

et al. 2017

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Natural products have been used as a major source of drugs for millennia, and about half of the pharmaceuticals in use today are derived from natural products. However, their efficacy can be limited because of their low hydrophilicity and intrinsic dissolution rate(s), or physical/chemical instability. In addition, they can present scarce absorption, poor pharmacokinetics and bioavailability, scarce biodistribution, first-pass metabolism, trivial penetration and accumulation in the organs of the body, or low targeting efficacy. Novel nanoformulations based on drug delivery systems, namely nanoparticles, micelles, and vesicles, offer significant promise in overcoming these limitations. Nowadays, nanomedicine is crucial in developing appropriate therapeutic treatments of essential drugs, specifically antitumor and antiparasistic agents (i.e., Taxol, vincristine, camptothecin, doxorubicin, artemisinin) and other emerging molecules with pleiotropic functions (i.e., resveratrol, curcumin, salvianolic acid B, honokiol). Additionally, the number of nanoformulations developed with flavonoids, in particular rutin, quercetin, silymarin, and green tea catechins, is constantly increasing, and a significant number of publications have appeared in the last decade pertaining to nanoformulations based on extracts and essential oils. Most of these studies report very promising nanoformulations with sustained release and improved bioavailability at much lower doses than conventional preparations, and in many cases, also a better safety profile.

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Optimization, characterization and in vitro evaluation of curcumin microemulsions

Cited by 88 publications

References 24 publications

Dual Effect of Curcumin–Zinc Complex in Controlling Diabetes Mellitus in Experimentally Induced Diabetic Rats

Dual Effect of Curcumin–Zinc Complex in Controlling Diabetes Mellitus in Experimentally Induced Diabetic Rats

Preparation, Characterization and Antioxidant Activity of Xanthone-Loaded Making (Hodgsonia Heteroclita) Microemulsions

Improving on Nature: The Role of Nanomedicine in the Development of Clinical Natural Drugs

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