Optimization, characterization, and in vitro assessment of alginate-pectin ionic cross-linked hydrogel film for wound dressing applications

Rezvanian, Masoud; Ahmad, Naveed; Amin, Mohd Cairul Iqbal Mohd; Ng, Shiow‐Fern

doi:10.1016/j.ijbiomac.2016.12.079

Cited by 223 publications

(111 citation statements)

References 37 publications

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“…Blank and GM-loaded AX films were prepared by the solvent-casting method [33]. The blank AX films were prepared by using different amounts of AX and glycerol (Table 1).…”

Section: Preparation Of Ax Filmsmentioning

confidence: 99%

“…The plates were incubated for 24 h, and then medium was replaced with 100 µL AX films extracts in sample wells and fresh medium in control wells. Then plates were again incubated for 24 h, and alamarBlue®assay (Invitrogen, Carlsbad, CA, USA) was performed to estimate the percentage of viable cells by measuring the optical density of the control and sample wells using microplate reader at 570 nm [33].…”

Section: Cell Viability Assaymentioning

confidence: 99%

“…The results of the mechanical testing are provided in Table 3. The blank and GM-loaded films prepared by using 2% AX (AXF2 and AXDF2) were damaged immediately after the start of experiments and their results could not be recorded; whereas the films AXF2.5, AXDF2.5, AXDF3, and AXDF3 exhibited tensile strength and elongation at break in the acceptable range [13,33]. Moreover, it was observed that the tensile strength of the films significantly increased with increasing AX content, indicating that higher AX content results in the formation of stronger films.…”

Section: Mechanical Characterizationmentioning

confidence: 99%

“…These results suggest that the WVTR decreased with increasing the AX content and the addition of GM, which can be attributed to the increase in thickness of the film. According to the literature, the WVTR values for normal and injured skin are 204 and 280-5100 g·m −2 per 24 h, respectively [33]. The WVTR of commercially available wound dressings usually range from Swelling is an important criterion for the selection of the films for wound dressing and drug delivery applications because when films are applied on a wound, they absorb the wound fluid and expand [36].…”

Section: Water Vapor Transmission Rate (Wvtr)mentioning

confidence: 99%

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Development and Characterization of Hemicellulose-Based Films for Antibacterial Wound-Dressing Application

et al. 2020

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Hemicelluloses are biopolymers with versatile properties for biomedical applications. Herein, hemicellulose (arabinoxylan)-based antibacterial film dressings were prepared and characterized. Arabinoxylan was isolated from psyllium husk. Blank and gentamicin-loaded films were prepared by the solvent cast method using glycerol as the plasticizer. The appropriate composition of the films was obtained by varying the amounts of arabinoxylan, glycerol, and gentamicin. The films were found to be transparent, smooth, bubble-free, flexible, and easily peelable with 2% to 3% arabinoxylan. They had uniform thickness and swelled up to 60% of their initial size. The mechanical properties and water vapor transmission rate through the films were found to be suitable for wound-dressing application. Fourier transform infrared spectroscopy (FTIR) analysis confirmed drug–film compatibility. In an in vitro release study, more than 85% of the gentamicin was released from the films in 12 h. The antibacterial activities of the gentamicin-loaded films were found to be close to the standard gentamicin solution. The films were found to be cytocompatible in cell viability assay. These results suggested that hemicellulose-based films are promising materials for the dressing of infected wounds.

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“…Blank and GM-loaded AX films were prepared by the solvent-casting method [33]. The blank AX films were prepared by using different amounts of AX and glycerol (Table 1).…”

Section: Preparation Of Ax Filmsmentioning

confidence: 99%

Section: Cell Viability Assaymentioning

confidence: 99%

Section: Mechanical Characterizationmentioning

confidence: 99%

Section: Water Vapor Transmission Rate (Wvtr)mentioning

confidence: 99%

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Development and Characterization of Hemicellulose-Based Films for Antibacterial Wound-Dressing Application

et al. 2020

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“…This occurred because of the alginate chain approximation, which could promote the development of roughness. For example, Rezvanian et al . observed shrinking in their pectin–alginate ionic crosslinked films when they were immersed in 0.5–3.0% CaCl 2 solutions.…”

Section: Resultsmentioning

confidence: 99%

Alginate and carboxymethyl cellulose in monolayer and bilayer films as wound dressings: Effect of the polymer ratio

Trevisol

Fritz

Souza

et al. 2018

J of Applied Polymer Sci

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In this study, we investigated different proportions of alginate and carboxymethyl cellulose (CMC) biopolymers in the formulation of films to act as wound dressings. With the casting method, monolayer and bilayer (BL) films were produced with alginate/ CMC proportions (weight percentages) of 0:100 (0A), 25:75 (25A), 50:50 (50A), 75:25 (75A), and 100:0 (100A). Thin, homogeneous, and continuous films were obtained with glycerol and crosslinking with CaCl 2 . The fluid uptake, film stability, and morphological, mechanical, thermal, and barrier properties were evaluated. A general tendency of the film characteristics was visualized: 50A had intermediary characteristics from both polymers; although the liquid behavior characteristics were improved with increasing CMC content, the mechanical properties worsened. When compared to the monolayer film (50A), the BL film 50A-BL demonstrated a better water vapor transmission rate. In this study, we demonstrated the necessity of varying the polymer concentrations to assist in the production of wound dressings.

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Hydrogel Dressings

Irmukhametova¹,

Mun²,

Khutoryanskiy³

2020

Therapeutic Dressings and Wound Healing Applications

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Optimization, characterization, and in vitro assessment of alginate-pectin ionic cross-linked hydrogel film for wound dressing applications

Cited by 223 publications

References 37 publications

Development and Characterization of Hemicellulose-Based Films for Antibacterial Wound-Dressing Application

Development and Characterization of Hemicellulose-Based Films for Antibacterial Wound-Dressing Application

Alginate and carboxymethyl cellulose in monolayer and bilayer films as wound dressings: Effect of the polymer ratio

Hydrogel Dressings

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