Optimization and physicochemical characterization of a triamcinolone acetonide-loaded NLC for ocular antiangiogenic applications

Follicular delivery of spironolactone via nanostructured lipid carriers for management of alopecia

“…21 The predicted R 2 values were in reasonable agreement with the adjusted R 2 in all responses (approximately 0.2 difference between them) (Table 3). 22,23 Adequate precision measured the signal-to-noise ratio to ensure that the model can be used to navigate the design space.…”

Curcumin-loaded nanostructured lipid carriers (NLCs) for nasal administration: design, characterization, and in vivo study

“…During processing of the samples, machine was coated with a heater tape and the temperature of the homogenization circuit was maintained at 85 ± 0.5 C to avoid the risk of boiling, in the sample-collecting deposit, a digital thermometer was placed. Ultimately, the resulting hot o/w nanoemulsion was cooled to 4 ± 0.5 C, recrystallization of the lipid and CRM-loaded NLCs (CRM-NLCs) were generated (Araújo et al, 2010). The CRM-NLCs' aqueous dispersion was centrifuge at 45 000 rpm for 35 min at room temperature by using Optima ''MAX-XP'' ultracentrifuge (Beckman Coulter, Nyon, Switzerland) for the separation of the nano-particulate system.…”

“…The z-average and PDI values were obtained at an angle of 90 using disposable polystyrene cells having 10 mm diameter cells at 25 C, which were equilibrating for 120 s. Refractive index (RI), for size measurement of lipid NPs dispersion, was set as RI ¼ 1.330 (abs ¼ 0.01). All measurements were performed in triplicate at 25 C (Araújo et al, 2010;.…”

The Impact of Variables on Particle Size of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers; A Comparative Literature Review

“…8 Nanolipid carriers have gained much interest in pharmaceutical sciences for several delivery routes, e.g., dermal, 11,12 oral, 13 parenteral, 14 pulmonary, [15][16][17][18] and ocular. 19,20 Solid lipid nanoparticles (SLNs) were introduced in the early 1990s as drug carriers. 21 They are prepared from one or blends of two or more solid lipids.…”