Optimising endoscopic management of early gastrointestinal neoplasia

Abstract

I n this issue of the Singapore Medical Journal, Koay et al (1) examined the role of narrow-band imaging (NBI), an image-enhanced endoscopy (IEE) technique, for the diagnosis of duodenal villous atrophy, while Li et al (2) and Tai et al (3) reported the early Singapore experience with colorectal endoscopic submucosal dissection (ESD). The aim of IEE as an adjunct to standard white light endoscopy is to improve endoscopic detection, characterisation and diagnosis of mucosal lesions. This would facilitate subsequent management strategies, including endoscopic resection or surgery. It is thus appropriate to take the opportunity to briefly examine the crucial issue of optimising endoscopic management of early gastrointestinal (GI) neoplasia. This would encompass preprocedural preparation, intraprocedural diagnosis, endoscopic treatment and post-resection follow-up options guided by histopathological findings.Endoscopy is the gold standard test for examining GI mucosa. However, to improve diagnostic yield, the mucosal surface must be clean and not obscured by mucus, fluids or other solid debris. Hence, adequate fasting, appropriate use of mucolytics and anti-foaming agents (for upper endoscopy), and good bowel preparation (for colonoscopy) are crucial. Quality endoscopic examinations are characterised by careful, deliberate and meticulous techniques. Surrogate markers of a quality examination include diagnostic procedure time, cleanliness of mucosal surface, completeness of examination, quality of captured endoscopic images and adenoma detection rates. IEE techniques are an important adjunct to white light endoscopy to improve lesion detection, characterisation and diagnosis. This may be achieved using dye spray chromoendoscopy such as the absorptive dye, Lugol's iodine, for detection of dysplastic oesophageal squamous lesions and the contrast dye, indigo carmine, which is used to highlight mildly elevated or mildly depressed mucosal lesions in the stomach and colon -or by equipment-based optical techniques. The latter techniques include NBI and blue light imaging, which focus on mucosal surface details and can be combined with optical magnification to characterise a detected lesion to determine whether it is neoplastic; if the lesion is neoplastic, the likelihood of deep submucosal involvement and feasibility of curative endoscopic resection are examined.Endoscopic classification systems based on these narrow-bandwidth imaging features have been established for the oesophagus, stomach and colon to guide treatment decisions. These include the intrapapillary capillary loop classification system for oesophageal squamous neoplasia, (4) the BING (Barrett's International NBI Group) classification system for Barrett's oesophagus, (5) the VS (vessel plus surface) classification system for early gastric cancer (6) and the NBI and JNET (Japan NBI Expert Team) classification systems for colorectal neoplasia. (7) It is important for an endoscopist to correctly describe the morphology of a detected lesion using the Paris morphol...