Optimal operation of simulated moving bed units for nonlinear chromatographic separations

Mazzotti, Marco; Storti, Giuseppe; Morbidelli, Massimo

doi:10.1016/s0021-9673(97)00048-4

Cited by 542 publications

(428 citation statements)

References 13 publications

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“…However, for non-linear competitive adsorption isotherms, which is the common case in chiral separations, the selection of the SMB operating conditions is not straightforward. The conditions for complete enantiomer separation were analyzed in the frame of the equilibrium theory, where mass transfer resistances and axial dispersion are neglected [15,16] Nevertheless, if mass transfer resistance is important, the region for complete separation is reduced and 100% pure enantiomers may not be obtained. In these cases, a purity criteria can be proposed and the region for separation (where both enantiomers purities are at least equal to the proposed purity criteria) can be evaluated.…”

Section: Simulation Resultsmentioning

confidence: 99%

Chiral separation by SMB chromatography

Pais

Loureiro

Rodrigues

2000

Separation and Purification Technology

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The paper deals with chiral separation by simulated moving bed (SMB) chromatography. A model for the prediction of the cyclic steady-state performance of the SMB, based on the analogy with the true moving bed (TMB), is developed assuming multicomponent adsorption equilibria, axial dispersion flow and the linear driving force approximation to describe the intraparticle mass transfer rate. The simulation package is used to predict the effect of operating variables on the process performance and to define the regions for enantiomers separation. The influence of mass transfer resistance in the separation region is analyzed. A practical tool for choosing the better SMB operating conditions as a function of the feed flow-rate is proposed. The experimental operation of a pilot unit of SMB, Licosep 12-26 (Novasep, France), is carried out for the separation of enantiomers and illustrated with two systems: the bi-naphthol and the chiral epoxide enantiomers. Experimental results and model predictions are compared in terms of process performance and internal concentration profiles.

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Section: Simulation Resultsmentioning

confidence: 99%

Chiral separation by SMB chromatography

Pais

Loureiro

Rodrigues

2000

Separation and Purification Technology

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“…The method adopted for the design of the experimental conditions (Mazzotti et al, 1997), as well as the assumption of linearity of the isotherms which describe the system were adequate for the range of concentrations tested, not higher than 5 g/L in the feed. The levels of enantiomeric purity were high, mainly for the stream of interest, i. e., the raffinate, whose purity was comparable to that of the standard ketamine S enantiomer.…”

Section: Discussionmentioning

confidence: 99%

“…After determination of the Henry constants, the procedure described by Mazzotti et al (1997) allowed choice of the operational conditions for SMB unit operation. It was assumed that the system operates under conditions dilute enough to be correctly represented by the linear isotherms.…”

Section: Continuous Runs In the Smb Unitmentioning

confidence: 99%

Simulated moving-bed adsorption for separation of racemic mixtures

Santos

Veredas

Silva

et al. 2004

Braz. J. Chem. Eng.

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-The two enantiomers that constitute a racemate have different activities when employed as pharmaceuticals. Due to this fact, fully recognized today, the pharmaceutical industry has been forced to market pure enantiomers instead of the racemic mixture whenever a chiral compound is involved. The simulated moving bed (SMB) is a chromatographic process that, unlike traditional HPLC systems, operates continuously without losing the enantiomeric purity of the outlet streams. The present work describes the enantioseparation of the anesthetic ketamine in a semipreparative-scale SMB unit. The chiral stationary phase employed was the microcrystalline cellulose triacetate. The outlet streams were analyzed by an on-line system, composed by an UV/VIS meter and a polarimeter, and also by HPLC. The analysis indicated purity values up to 100% for the stream of interest and up to 97.7% for the other stream.

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“…They assumed that mass transfer resistances and axial dispersion are negligible, and the adsorption equilibria were described through a variable selectivity modified Langmuir isotherm. [26] The conditions to achieve complete separation were evaluated considering the equivalent true moving bed operation. Following the assumptions of the equilibrium theory, they provided explicit criteria for the choice of the SMB operating conditions that lead to complete separation of a binary mixture.…”

Section: Design Of Smb Chiral Separationsmentioning

confidence: 99%

“…Operating conditions for complete separation under equilibrium theory: Langmuir adsorption isotherms. [26] …”

Section: Steady-state Tmb Modelmentioning

confidence: 99%

Design of SMB Chiral Separations Using the Concept of Separation Volume

Rodrigues

Pais

2005

Separation Science and Technology

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The article deals with chiral separation by simulated moving bed (SMB) chromatography. When mass transfer resistances are negligible, equilibrium theory provides explicit criteria for the choice of the SMB operating conditions. However, in the presence of mass transfer resistances, the SMB operating conditions should be evaluated through simulation. Using a package based on the analogy with the true moving bed operation, this work shows how mass transfer resistance can affect the conditions for enantiomers separation, as well as the critical values stated by equilibrium theory. The concept of separation volume is applied to show how the flow-rate constraints, in presence of mass transfer

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Optimal operation of simulated moving bed units for nonlinear chromatographic separations

Cited by 542 publications

References 13 publications

Chiral separation by SMB chromatography

Chiral separation by SMB chromatography

Simulated moving-bed adsorption for separation of racemic mixtures

Design of SMB Chiral Separations Using the Concept of Separation Volume

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