Optimal Glass-Forming Solvent Brings Sublimation Dynamic Nuclear Polarization to <sup>129</sup>Xe Hyperpolarization Biomedical Imaging Standards

Capozzi, Andrea; Roussel, Christophe; Comment, Arnaud; Hyacinthe, Jean-Noël

doi:10.1021/jp5124053

Cited by 23 publications

(36 citation statements)

References 40 publications

(101 reference statements)

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“…Although hp 129 Xe can be obtained through dynamic nuclear polarization (25) with high spin-polarization levels of up to P = 30% (26), at present only SEOP can produce hp 129 Xe with P ≥ 90%. Furthermore, SEOP is currently the only method to provide hp 83 Kr for biomedical MRI applications (24).…”

mentioning

confidence: 98%

Molecular hydrogen and catalytic combustion in the production of hyperpolarized⁸³Kr and¹²⁹Xe MRI contrast agents

Rogers

Hill-Casey

Stupic

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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Hyperpolarized (hp) 83 Kr is a promising MRI contrast agent for the diagnosis of pulmonary diseases affecting the surface of the respiratory zone. However, the distinct physical properties of 83 Kr that enable unique MRI contrast also complicate the production of hp 83 Kr. This work presents a previously unexplored approach in the generation of hp 83 Kr that can likewise be used for the production of hp 129 Xe. Molecular nitrogen, typically used as buffer gas in spin-exchange optical pumping (SEOP), was replaced by molecular hydrogen without penalty for the achievable hyperpolarization. In this particular study, the highest obtained nuclear spin polarizations were P = 29% for 83 Kr and P = 63% for 129 Xe. The results were reproduced over many SEOP cycles despite the laser-induced on-resonance formation of rubidium hydride (RbH). Following SEOP, the H 2 was reactively removed via catalytic combustion without measurable losses in hyperpolarized spin state of either Xe can be obtained through dynamic nuclear polarization (25) with high spin-polarization levels of up to P = 30% (26) He-N 2 mixture or pure N 2 gas. The buffer gas serves a dual purpose as it prevents destructive radiation trapping, originating from radiative electronic relaxation of rubidium (27, 28), but also causes pressure broadening of the Rb D 1 linewidth. Rubidium line broadening maximizes adsorption of laser light emitted by high-power solid devices, even if those are line narrowed. Following SEOP, hp 129

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mentioning

confidence: 98%

Molecular hydrogen and catalytic combustion in the production of hyperpolarized⁸³Kr and¹²⁹Xe MRI contrast agents

Rogers

Hill-Casey

Stupic

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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“…Recently, Capozzi et al [82] has proposed a DNP method to hyperpolarize Xe nuclei, at very low temperature, using different organic solvents and TEMPO radical ( Figure 3). …”

Section: (A) Dnp Methodsmentioning

confidence: 99%

129Xenon NMR: Review of recent insights into porous materials

Weiland

Springuel‐Huet

Nossov

et al. 2016

Microporous and Mesoporous Materials

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“…A home-built spectrometer was used to record the NMR spectra with small flip angle pulses (2)(3)(4)(5)(6). The repetition time between excitations was no shorter than 20 min.…”

Section: Dnp Systemmentioning

confidence: 99%

Low‐temperature dynamic nuclear polarization of gases in Frozen mixtures

Pourfathi

Clapp

Kadlecek

et al. 2015

Magnetic Resonance in Med

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Purpose To present a new cryogenic technique for preparing gaseous compounds in solid mixtures for polarization using dynamic nuclear polarization (DNP). Methods 129Xe and 15N2O samples were prepared using the presented method. Samples were hyperpolarized at 1.42K at 5T. 129Xe was polarized at 1.65K and 1.42K to compare enhancement. Polarization levels for both samples and T1 relaxation times for the 129Xe sample were measured. Sample pulverization for the 129Xe and controlled annealing for both samples were introduced as additional steps in sample preparation. Results Enhancement increased by 15% due to a temperature drop from 1.65K to 1.42K for the 129Xe sample. A polarization level of 20±3% for the 129Xe sample was achieved, a 2-fold increase from 10±1% after pulverization of the sample at 1.42K. T1 of the 129Xe sample was increased by more than 3-fold via annealing. In the case of 15N2O, annealing led to a ~2-fold increase in the signal level after DNP. Conclusion The presented technique for producing and manipulating solid gas/glassing agent/radical mixtures for DNP led to high polarization levels in 129Xe and 15N2O samples. These methods show potential for polarizing other gases using DNP technology.

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Optimal Glass-Forming Solvent Brings Sublimation Dynamic Nuclear Polarization to ¹²⁹Xe Hyperpolarization Biomedical Imaging Standards

Cited by 23 publications

References 40 publications

Molecular hydrogen and catalytic combustion in the production of hyperpolarized⁸³Kr and¹²⁹Xe MRI contrast agents

Molecular hydrogen and catalytic combustion in the production of hyperpolarized⁸³Kr and¹²⁹Xe MRI contrast agents

129Xenon NMR: Review of recent insights into porous materials

Low‐temperature dynamic nuclear polarization of gases in Frozen mixtures

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Optimal Glass-Forming Solvent Brings Sublimation Dynamic Nuclear Polarization to 129Xe Hyperpolarization Biomedical Imaging Standards

Cited by 23 publications

References 40 publications

Molecular hydrogen and catalytic combustion in the production of hyperpolarized83Kr and129Xe MRI contrast agents

Molecular hydrogen and catalytic combustion in the production of hyperpolarized83Kr and129Xe MRI contrast agents

129Xenon NMR: Review of recent insights into porous materials

Low‐temperature dynamic nuclear polarization of gases in Frozen mixtures

Contact Info

Product

Resources

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Optimal Glass-Forming Solvent Brings Sublimation Dynamic Nuclear Polarization to ¹²⁹Xe Hyperpolarization Biomedical Imaging Standards

Molecular hydrogen and catalytic combustion in the production of hyperpolarized⁸³Kr and¹²⁹Xe MRI contrast agents

Molecular hydrogen and catalytic combustion in the production of hyperpolarized⁸³Kr and¹²⁹Xe MRI contrast agents