Optical trapping for biosensing: materials and applications

Rodríguez‐Sevilla, Paloma; Labrador‐Páez, Lucía; Jaque, Daniel; Haro‐González, P.

doi:10.1039/c7tb01921a

Cited by 54 publications

(34 citation statements)

References 103 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Optical trapping has emerged as a reliable technique to achieve precise translation and rotational control over micro‐ and nanostructures . It is a contactless technique that has been already used for long‐term studies of single cells and bacteria .…”

Section: Introductionmentioning

confidence: 99%

Single‐Cell Biodetection by Upconverting Microspinners

Ortiz‐Rivero

Prorok

Skowickł

et al. 2019

Small

Self Cite

View full text Add to dashboard Cite

Near-infrared-light-mediated optical tweezing of individual upconverting particles has enabled all-optical single-cell studies, such as intracellular thermal sensing and minimally invasive cytoplasm investigations. Furthermore, the intrinsic optical birefringence of upconverting particles renders them lightdriven luminescent spinners with a yet unexplored potential in biomedicine. In this work, the use of upconverting spinners is showcased for the accurate and specific detection of single-cell and single-bacteria attachment events, through real-time monitoring of the rotation velocity of the spinner. The physical mechanisms linking single-attachment to the angular deceleration of upconverting spinners are discussed in detail. Concomitantly, the upconversion emission generated by the spinner is harnessed for simultaneous thermal sensing and thermal control during the attachment event. Results here included demonstrate the potential of upconverting particles for the development of fast, highsensitivity, and cost-effective systems for single-cell biodetection. www.advancedsciencenews.com Figure 6. a) Time evolution of rotation velocity of a surface functionalized single UCSPN during the process of adhesion of a single bacterium. The control data, obtained with a nonfunctionalized UCSPN, is also shown for comparison. This control data has been obtained during the process of interaction between a single bacterium and the nonfunctionalized UCSPN. The bacterium-UCSPN friction produces a transient decrease in the angular velocity. b) Sequential optical images of both functionalized and nonfunctionalized UCSPN obtained when a bacterium circulates in their proximity. Note, that bacterium adhesion is only observed for the surface functionalized UCSPN. 9 of 9) www.advancedsciencenews.com (

show abstract

Section: Introductionmentioning

confidence: 99%

Single‐Cell Biodetection by Upconverting Microspinners

Ortiz‐Rivero

Prorok

Skowickł

et al. 2019

Small

Self Cite

View full text Add to dashboard Cite

show abstract

“…Presently, optical trapping is employed as a tool for a wide range of experiments of biological relevance. Some of the biological applications of optical trapping methods were reviewed by Fazal and Block [118] and by Villangca et al [119] Optical trapping for biosensing was recently reviewed by Rodríguez-Sevilla et al [120] The most widespread applications of optical trapping in biology are briefly discussed in the following sections and shown schematically in Reproduced with permission. [126] Copyright 2005, Springer Nature.…”

Section: Applications For Biological Samplesmentioning

confidence: 99%

Strategies for Optical Trapping in Biological Samples: Aiming at Microrobotic Surgeons

Bunea

Glückstad

2019

Laser & Photonics Reviews

View full text Add to dashboard Cite

Optical trapping and manipulation of objects down to the Ångstrom level has revolutionized research at the smallest scales in all natural sciences. The flexibility of optical trapping methods facilitates real‐time monitoring of the dynamics of biological processes in model systems and even in living cells. Different optical trapping and manipulation approaches allow displacement of nanostructures with subnanometer precision and force measurements with femtonewton precision. Due to inherent constraints of optical methods, most optical trapping experiments are performed in water or simple aqueous solutions. However, in recent years, there is an ever‐growing interest of shifting from simple aqueous media towards more biologically‐relevant media. Precise optical trapping and manipulation, combined with state‐of‐the‐art microfabrication, will enable the development of microrobotic “surgeons” with tremendous potential for biomedical and microengineering applications. This review introduces the basics of optical trapping and discusses its applications for biological samples, with focus on trapping in biological media and strategies for overcoming the challenges of optical manipulation in complex environments as a stepping‐stone for microrobotic “surgeons.”

show abstract

“…The possibility of non-destructively trapping and transport of individual sub-micrometer objects are highly benefit in different fields of life sciences [1][2][3][4] like microfabrication [5], chemical research [6], optics [7] and biological [8], including the precise control of single biomolecules and drug delivery to living cells. The multidisciplinary nature of optomechanical manipulation of nanoparticles has allowed bringing together seemingly unrelated fields, such as electromagnetic or/and acoustical physics, biology, paving the way for a plethora of emerging applications.…”

Section: Introductionmentioning

confidence: 99%

Recent Trends in Optical Manipulation Inspired by Mesoscale Photonics and Diffraction Optics

Minin

2020

J-BPE

View full text Add to dashboard Cite

The spatial resolution of conventional optics, which is need for nondestructively trapping of microobjects, is limited by diffraction to nearly half the wavelength. Despite this limitation, the use of optical methods is one of the main directions in biological and biomedical researches, since only the use of optical methods has a minimal effect on living organisms. Quick progress in this field is based on a large extent on the development of new optical technologies and significant progress in the mesoscale photonics enabled the researches to obtain novel, previously unachievable information. Below we discussed some recent trends in optical manipulations on wavelength scale based on diffractive elements mesoscale dielectric particles as a field localization object and classical diffractive optical elements with unusual properties.

show abstract

Optical trapping for biosensing: materials and applications

Cited by 54 publications

References 103 publications

Single‐Cell Biodetection by Upconverting Microspinners

Single‐Cell Biodetection by Upconverting Microspinners

Strategies for Optical Trapping in Biological Samples: Aiming at Microrobotic Surgeons

Recent Trends in Optical Manipulation Inspired by Mesoscale Photonics and Diffraction Optics

Contact Info

Product

Resources

About