Optical ring resonators for biochemical and chemical sensing

Sun, Yuze; Fan, Xudong

doi:10.1007/s00216-010-4237-z

Cited by 317 publications

(214 citation statements)

References 69 publications

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“…Therefore, the existance of the immobilized antibody leads to wavelength shifts. 6,37,38 Moreover, as shown in Fig. 3(d), in order to explore the effect of an antibody thin layer on the resonance, we calculated the theoretical scattering cross-section spectra of a PS microsphere using Mie scattering theory.…”

Section: Wgm Spectra Evaluation Of the Antibody Immobilization Ps Micmentioning

confidence: 99%

Optical Characterization of the Antigen-Antibody Thin Layer Using the Whispering Gallery Mode

et al. 2014

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We immobilized an antibody (anti-β-Galactosidase) on a polystyrene microsphere by using a covalent bond, and observed the resonance peaks in the scattered light intensity spectra related to the whispering gallery mode (WGM) excitation of the microsphere. The amount and the optical parameters, i.e., thickness and refractive index, of anti-β-Galactosidase on the sphere surface were evaluated based on an absorbance measurement and a resonance peak shift measurement, respectively. Moreover, we measured the variation of the WGM spectra depending on the concentration of the enzyme solution (β-Galactosidase), which allowed us to optically evaluate the thickness and the refractive index of the antigen-antibody layer from the shift of the WGM spectra peak.

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Section: Wgm Spectra Evaluation Of the Antibody Immobilization Ps Micmentioning

confidence: 99%

Optical Characterization of the Antigen-Antibody Thin Layer Using the Whispering Gallery Mode

et al. 2014

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“…Optical resonators are an emerging technology for high sensitivity miniaturized biological or biochemical sensing [37]. Because in these devices the interaction length between the light and liquid sample is not limited by the physical length but is related to the number of revolutions of light in the resonator, characterised by the quality factor Q, they allow to obtain high sensitivity with very compact dimensions.…”

Section: Optofluidic Resonatorsmentioning

confidence: 99%

Optofluidics: a new tool for sensing

Testa¹,

Persichetti²,

Zeni

et al. 2013

SPIE Proceedings

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Over the last years optofluidics has emerged as a very promising field. The integration at microscopic level between optics and microfluidics provides a number of unique characteristics that cannot be obtained with solid materials only. This paper briefly reviews the state of the art on optofluidics for sensing applications. We first describe the different approaches in order to realized optofluidic waveguides. These waveguides allow an increased interaction efficiency between the light and the liquid substance that can be very useful in sensing applications (fluorescence, absorption spectroscopy, etc.). We then illustrate high sensitive optofluidic devices such as Mach-Zehnder interferometers, FabryPérot cavities and ring resonators. Examples of applications of optofluidic sensors for chemical and biological analysis are given.

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“…These challenges have been partly addressed by a range of label-free diagnostic platforms, many based on optical 1,2 or electrochemical [3][4][5] transduction of a biological event. Resonant silicon photonic devices such as microrings [6][7][8] and photonic crystal cavities 1,9,10 have been demonstrated to have considerable potential, as they offer high sensitivity, label-free detection in a format that can be mass-manufactured and have been commercialized successfully 11 . The critical property of silicon, which is the key to its widespread use in photonic biosensors, is its high refractive index.…”

mentioning

confidence: 99%

“…In part, this is due to the apparent conflict between the optimal material properties required by electrochemical and photonic sensors; electrochemistry requires materials of high conductivity, that is, high doping density, while ideal photonic materials have a low doping density in order to minimize free carrier losses. For example, a doping density of nE10 18 cm À 3 , which leads to a moderate conductivity of E45 S cm À 1 , is already sufficient to limit the Q-factor (resonance frequency divided by the spectral width at half maximum) to B10,000-much lower than the typical values of 40,000-140,000 associated with microring resonator sensors 7,8,12,13 .…”

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confidence: 99%

The Electro-Photonic Silicon Biosensor

Colas¹

2017

Dual-Mode Electro-Photonic Silicon Biosensors

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The emergence of personalized and stratified medicine requires label-free, low-cost diagnostic technology capable of monitoring multiple disease biomarkers in parallel. Silicon photonic biosensors combine high-sensitivity analysis with scalable, low-cost manufacturing, but they tend to measure only a single biomarker and provide no information about their (bio)chemical activity. Here we introduce an electrochemical silicon photonic sensor capable of highly sensitive and multiparameter profiling of biomarkers. Our electrophotonic technology consists of microring resonators optimally n-doped to support high Q resonances alongside electrochemical processes in situ. The inclusion of electrochemical control enables site-selective immobilization of different biomolecules on individual microrings within a sensor array. The combination of photonic and electrochemical characterization also provides additional quantitative information and unique insight into chemical reactivity that is unavailable with photonic detection alone. By exploiting both the photonic and the electrical properties of silicon, the sensor opens new modalities for sensing on the microscale.

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Optical ring resonators for biochemical and chemical sensing

Cited by 317 publications

References 69 publications

Optical Characterization of the Antigen-Antibody Thin Layer Using the Whispering Gallery Mode

Optical Characterization of the Antigen-Antibody Thin Layer Using the Whispering Gallery Mode

Optofluidics: a new tool for sensing

The Electro-Photonic Silicon Biosensor

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