Optical innovations in surgery

Boer, Esther de; Harlaar, Niels J.; Taruttis, Adrian; Nagengast, Wouter B.; Rosenthal, Eben L.; Ntziachristos, Vasilis; Dam, van Gooitzen

doi:10.1002/bjs.9713

Cited by 141 publications

(116 citation statements)

References 74 publications

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“…Next to visualization of other targets with antibodies, smaller fragments like nanobodies targeting specific tumor markers, such as carbonic anhydrase IX, HER2, and CEA, have been developed more recently for imaging solid tumors. This could also be validated by NIR optical imaging (in situ and ex vivo) and MAPI in future translational clinical studies (41)(42)(43). Moreover, this study has shown that MAPI can be used ex vivo to cross-correlate the fluorescent-labeled therapeutic drug bevacizumab and its tumor-specific targeting and local tumor distribution in humans by using excised specimens.…”

Section: Discussionmentioning

confidence: 74%

“…Currently, three studies are ongoing to determine feasibility of a fluorescent endoscope attached to the camera system after administration of 4.5 mg bevacizumab-IRDye800CW intravenously to detect rectal cancer, esophageal cancer, and premalignant and malignant polyps in familial adenomatous polyposis (ClinicalTrials.gov identifiers NCT01972373, NCT02129933, and NCT02113202). This approach is therefore of interest not only for tumor visualization and characterization in intraoperative surgical guidance, but also for diagnostic purposes, drug development, and treatment monitoring (42).…”

Section: Discussionmentioning

confidence: 99%

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Tumor-Specific Uptake of Fluorescent Bevacizumab–IRDye800CW Microdosing in Patients with Primary Breast Cancer: A Phase I Feasibility Study

Lamberts

Koch

Jong

et al. 2017

Clinical Cancer Research

230

191

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Purpose: To provide proof of principle of safety, breast tumorspecific uptake, and positive tumor margin assessment of the systemically administered near-infrared fluorescent tracer bevacizumab-IRDye800CW targeting VEGF-A in patients with breast cancer.Experimental Design: Twenty patients with primary invasive breast cancer eligible for primary surgery received 4.5 mg bevacizumab-IRDye800CW as intravenous bolus injection. Safety aspects were assessed as well as tracer uptake and tumor delineation during surgery and ex vivo in surgical specimens using an optical imaging system. Ex vivo multiplexed histopathology analyses were performed for evaluation of biodistribution of tracer uptake and coregistration of tumor tissue and healthy tissue.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Tumor-Specific Uptake of Fluorescent Bevacizumab–IRDye800CW Microdosing in Patients with Primary Breast Cancer: A Phase I Feasibility Study

Lamberts

Koch

Jong

et al. 2017

Clinical Cancer Research

230

191

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“…Initially used in the detection of macular degeneration8, the technique of angiography using indocyanine green (ICG) has been used to identify sentinel lymph nodes9, to determine the extent of oncological resections10 and to study hepatic function11. Recent studies have also demonstrated its usefulness in evaluating the vascular blood flow of intestinal anastomoses12.…”

Section: Introductionmentioning

confidence: 99%

Parathyroid gland angiography with indocyanine green fluorescence to predict parathyroid function after thyroid surgery

Fortuny

Belfontali

Sadowski

et al. 2016

British Journal of Surgery

148

130

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BackgroundPostoperative hypoparathyroidism remains the most common complication following thyroidectomy. The aim of this pilot study was to evaluate the use of intraoperative parathyroid gland angiography in predicting normal parathyroid gland function after thyroid surgery.MethodsAngiography with the fluorescent dye indocyanine green (ICG) was performed in patients undergoing total thyroidectomy, to visualize vascularization of identified parathyroid glands.ResultsSome 36 patients underwent ICG angiography during thyroidectomy. All patients received standard calcium and vitamin D supplementation. At least one well vascularized parathyroid gland was demonstrated by ICG angiography in 30 patients. All 30 patients had parathyroid hormone (PTH) levels in the normal range on postoperative day (POD) 1 and 10, and only one patient exhibited asymptomatic hypocalcaemia on POD 1. Mean(s.d.) PTH and calcium levels in these patients were 3·3(1·4) pmol/l and 2·27(0·10) mmol/l respectively on POD 1, and 4·0(1.6) pmol/l and 2·32(0·08) mmol/l on POD 10. Two of the six patients in whom no well vascularized parathyroid gland could be demonstrated developed transient hypoparathyroidism. None of the 36 patients presented symptomatic hypocalcaemia, and none received treatment for hypoparathyroidism.Conclusion PTH levels on POD 1 were normal in all patients who had at least one well vascularized parathyroid gland demonstrated during surgery by ICG angiography, and none required treatment for hypoparathyroidism.

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“…Initially ICG was used in ophthalmology for the detection of macular degeneration (36). Subsequently, ICG angiography has been used to identify sentinel lymph nodes (37), determine the extent of oncologic resections (38), and study hepatic function (39).…”

Section: Fluorescent Techniques With Icg In Neck Surgerymentioning

confidence: 99%

A reappraisal of vascular anatomy of the parathyroid gland based on fluorescence techniques

Sadowski¹,

Fortuny²,

Triponez³

2017

Gland Surg.

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Optical innovations in surgery

Cited by 141 publications

References 74 publications

Tumor-Specific Uptake of Fluorescent Bevacizumab–IRDye800CW Microdosing in Patients with Primary Breast Cancer: A Phase I Feasibility Study

Tumor-Specific Uptake of Fluorescent Bevacizumab–IRDye800CW Microdosing in Patients with Primary Breast Cancer: A Phase I Feasibility Study

Parathyroid gland angiography with indocyanine green fluorescence to predict parathyroid function after thyroid surgery

A reappraisal of vascular anatomy of the parathyroid gland based on fluorescence techniques

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