Optical Coherence Tomography Angiography in the Multimodal Imaging Evaluation of Interferon-Associated Retinopathy: A Case Report

Abstract

The authors present the case of a 59-year-old woman in treatment with interferon alfa-2b for stage IV melanoma and widespread metastases who presented with interferon-associated retinopathy. An ocular examination revealed multiple retinal cotton-wool spots and hard exudates. Interferon treatment was suspended. The patient was followed up for 5 months following the baseline visit by means of en face optical coherence tomography (OCT), spectral-domain OCT, and OCT angiography. Multimodal imaging was useful in the follow-up of this condition, permitting the characterization of all the lesions hallmarking the interferon-retinopathy and showing that this illness was related to a reduction of the retinal vascular perfusion. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:498-504.].

Dispersion mapping as a simple postprocessing step for Fourier domain Optical Coherence Tomography data

“…Functional OCT techniques use different contrast mechanisms, birefringence in PS OCT or elastic modulus in OCE, to identify sections of a sample with different properties and require little alteration to the system or, in the vast majority of cases, no alterations at all. Techniques that don't add any complexity to the system are very much sought for as they can be universally used for multimodal imaging and, thus, provide complementary data in a single examination [21][22][23][24][25] .…”