Optical coherence tomography angiography in the diagnosis of retinal microvascular changes in chronic kidney disease (clinical observations)

Фурсова, А. Ж.; Васильева, Мария; Derbeneva, A S; Tarasov, M S; Chubar, N V; Nikulich, I F; Gusarevitch, O G

doi:10.17116/oftalma202113703197

Cited by 11 publications

(5 citation statements)

References 15 publications

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“…Further trials have generated different findings, as they report a reduction of FD at the level of the DCP and an increase in FD in the SCP for hypotensive patients [14]. Fursova et al described a decrease in the circularity index of the FAZ associated with HD treatment [32]. We found no significant difference in regards to FAZ related parameters between ESRD patients treated with HD and control patients.…”

Section: Discussioncontrasting

confidence: 54%

“…FD was observed to be reduced in the group of patients with renal impairment [16]. Various authors describe a negative correlation between OCTA-derived FD values and renal function [15,32,33]. However, it remains unclear whether this correlation is still visible in patients receiving HD treatment.…”

Section: Discussionmentioning

confidence: 98%

“…It remains unclear whether HD itself, or rather the underlying renal disease, has caused the reduction in retinal FD. It is probable that ESRD is the main cause of FD decrease, as it has been shown to be associated with reduction in ocular perfusion [15,32,33]. HD, being the main treatment method for ESRD patients, might have a positive influence on FD values and could therefore attenuate the effect that ESRD has on FD measurement results.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Ocular Perfusion in Patients with End-Stage Renal Disease Receiving Hemodialysis Using Optical Coherence Tomography Angiography

Lahme¹,

Storp²,

Marchiori

et al. 2023

JCM

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Hemodialysis (HD) is known to affect ocular blood flow. This case-control study aims to evaluate macular and peripapillary vasculature in patients with end-stage renal disease (ESRD) receiving HD in comparison to matched controls. A total of 24 eyes of 24 ESRD patients receiving HD and 24 eyes of 24 healthy, age- and gender-matched control subjects were prospectively included in this study. Optical coherence tomography angiography was used to image the superficial (SCP), deep (DCP), and choriocapillary (CC) macular vascular plexus, as well as the radial peripapillary capillaries (RPC) of the optic disc. In addition, retinal thickness (RT) and retinal volume (RV) were compared between both groups. Flow density (FD) values of each retinal layer and data of parameters related to the foveal avascular zone (FAZ), as well as RT and RV, were analyzed using Mann–Whitney U tests. There was no significant difference in FAZ parameters between the two groups. Whole en face FD of the SCP and CC was noticeably reduced in the HD group in comparison to the control group. FD was negatively correlated with the duration of HD treatment. RT and RV were significantly smaller in the study group than in controls. Retinal microcirculation appears altered in patients with ESRD undergoing HD. Concurrently, the DCP appears more resilient towards hemodynamic changes in comparison to the other microvascular retinal layers. OCTA is a useful, non-invasive tool to investigate retinal microcirculation in ESRD patients.

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Section: Discussioncontrasting

confidence: 54%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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Evaluation of Ocular Perfusion in Patients with End-Stage Renal Disease Receiving Hemodialysis Using Optical Coherence Tomography Angiography

Lahme¹,

Storp²,

Marchiori

et al. 2023

JCM

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“…OCTA is a noninvasive, accessible, and relatively inexpensive method for monitoring macular blood ow. Previous studies have shown changes in macular blood ow in patients with hypertension, chronic kidney disease, hemodialysis, diabetes, and in ammatory diseases [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Macular microvasculature in patients with thyroid-associated orbitopathy compared to healthy individuals, foveal avascular zone area as a biomarker for disease activity

Abrishami

Sabermoghaddam

Salahi

et al. 2022

Preprint

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Purpose: The aim of this study was to evaluate macular blood flow in patients with thyroid-associated orbitopathy (TAO) compare to healthy subjects. Methods: This is a cross-sectional study with the convenience sampling method. Macular flow density was assessed using optical coherence tomography angiography (OCTA) and compared between patients with TAO and healthy individuals. We also compared macular flow density in two subgroups of patients based on clinical activity score (CAS). Results: Eighty–five cases, including 30 healthy individuals and 55 patients with TAO, participated. The foveal avascular zone (FAZ) area was significantly higher in the patient group than in the control. A comparison of flow data between the two subgroups of patients showed a significant difference in the FAZ area (p=0.041). Conclusion: We showed that the FAZ area has an increasing trend from healthy individuals to active TAO patients and can be considered a possible candidate for monitoring the disease activity and thyroid-associated vasculopathy.

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“…For example, OCTA evaluation of patients with hypertension has shown that poor control of hypertension was associated with focal ischemia of the choroid, which may be caused by choroid endothelial injury and vasoconstriction 15 . OCTA evaluation of patients with chronic kidney disease (CKD) found that retinal vascular density and the circularity index of the foveal avascular zone gradually decrease as kidney function decreases 16 . Superficial parafoveal density and superficial foveal density were shown to be lower in eyes of patients with than without systemic lupus erythematosus (SLE), with these densities being negatively correlated with SLE Disease Activity Index 17 .…”

Section: Introductionmentioning

confidence: 99%

Ocular microvascular alteration in patients with myocardial infarction—a new OCTA study

Wu,

Hu,

et al. 2024

Sci Rep

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Myocardial infarction is defined as a sudden decrease or interruption in blood flow to the coronary arteries, causing ischemic necrosis of the corresponding cardiomyocytes. It is unclear whether systemic macrovascular alterations are associated with retinal microvascular changes. This study utilized optical coherence tomography angiography (OCTA) to compare variations in conjunctival vascular density and fundus retinal vessel density between patients with myocardial infarction (MI) and healthy controls. This study recruited 16 patients (32 eyes) with MI and 16 healthy controls (32 eyes). The superficial retinal layer (SRL), deep retinal layer (DRL) and conjunctival capillary plexus in each eye were evaluated by OCTA. Parameters measured included the density of the temporal conjunctival capillary, retinal microvascular (MIR) and macrovascular (MAR) alterations and total MIR (TMI). The microvascular density of each retinal region was evaluated by the hemisphere segmentation (SR, SL, IL, and IR), annular partition (C1, C2, C3, C4, C5 and C6), and modified early treatment of diabetic retinopathy study (R, S, L, and I) methods. In the macular area, the superficial and deep retinal microvascular densities displayed notable variations. In the superficial layers, the superficial TMI, superficial MIR, and superficial MAR, as well as densities in the SL, IL, S, L, C1, C2, C5 and C6 regions, were significantly lower in MI patients (p < 0.05 each). In the deep layers, the deep MIR and deep TMI), as well as densities in the SL, IL, L, C1, C2 and C6 regions were significantly lower in MI patients (p < 0.05 each). In contrast, the conjunctival microvascular density was significantly higher in MI patients than in healthy controls (p < 0.001). The microvascular densities measured in the deep and superficial retinal layers and in the conjunctiva differ in MI patients and healthy controls. OCTA is effective in detecting changes in the ocular microcirculation.

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Optical coherence tomography angiography in the diagnosis of retinal microvascular changes in chronic kidney disease (clinical observations)

Cited by 11 publications

References 15 publications

Evaluation of Ocular Perfusion in Patients with End-Stage Renal Disease Receiving Hemodialysis Using Optical Coherence Tomography Angiography

Evaluation of Ocular Perfusion in Patients with End-Stage Renal Disease Receiving Hemodialysis Using Optical Coherence Tomography Angiography

Macular microvasculature in patients with thyroid-associated orbitopathy compared to healthy individuals, foveal avascular zone area as a biomarker for disease activity

Ocular microvascular alteration in patients with myocardial infarction—a new OCTA study

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