Optical Coherence Tomography Angiography in Neurodegenerative Disorders

Pellegrini, Marco; Vagge, Aldo; Desideri, Lorenzo Ferro; Bernabei, Federico; Triolo, Giacinto; Mastropasqua, Rodolfo; Noce, Chiara Del; Borrelli, Enrico; Sacconi, Riccardo; Iovino, Claudio; Zazzo, Antonio Di; Forlini, Matteo; Giannaccare, Giuseppe

doi:10.3390/jcm9061706

Cited by 50 publications

(33 citation statements)

References 123 publications

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“…As a consequence, the calculated vessel cross sectional area differences are 5.2% for SVP, 10% for ICP, and 3.8% for DCP. These differences, even if not directly comparable, are relevant compared to other retinal conditions affecting vessels diameter and blood flow, as systemic hypertension or central nervous system vascular neurodegenerative diseases [ 18 , 19 ]. Therefore, VHL disease needs to be better investigated in a scenario of complex disorders involving microvasculature.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the presence of tiny clinically undetectable RHs, visible just with fluorescein angiography, cannot be excluded. Another limitation is that genotype-phenotypes correlation was not performed [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. Therefore, we cannot exclude that the genotype of VHL germline mutation may differently influence retinal vascular development and perfusion.…”

Section: Discussionmentioning

confidence: 99%

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Macular Perfusion Impairment in Von Hippel-Lindau Disease Suggests a Generalized Retinal Vessel Alteration

Pilotto

Nacci

Ferrara

et al. 2020

JCM

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Background: To evaluate macular perfusion in patients with Von Hippel–Lindau (VHL) disease. Methods: VHL patients with or without peripheral retinal hemangioblastomas (RHs) were consecutively enrolled. A group of healthy subjects served as controls. Macular perfusion was analyzed by means of OCT angiography (OCTA) in the superficial vascular plexus (SVP), and in the intermediate (ICP) and deep retinal capillary (DCP) plexuses. The following OCTA parameters were measured: Vessel Area Density (VAD), Vessel Length Fraction (VLF), Vessel Diameter Index (VDI) and Fractal Dimension (FD). Results: Sixty-three VHL patients (113 eyes) and 28 healthy controls (56 eyes) were enrolled. All OCTA quantitative parameters were reduced in VHL patients vs. controls, reaching statistical significance for VAD of the SVP (0.348 ± 0.07 vs. 0.369 ± 0.06, p = 0.0368) and VDI of all plexuses (p < 0.03 for all). No significant differences were detected between eyes without or with peripheral RHs. Conclusions: Macular perfusion is reduced in VHL patients demonstrating retinal vessel changes that are independent of the presence of peripheral RHs. VHL gene mutations disrupt the hypoxia-induced (HIF)/vascular endothelium growth factors (VEGF) pathway and the Notch signaling, both essential for the normal retinal vasculogenesis and angiogenesis. Therefore, an anomalous generalized retinal vascular development may be hypothesized in VHL disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Macular Perfusion Impairment in Von Hippel-Lindau Disease Suggests a Generalized Retinal Vessel Alteration

Pilotto

Nacci

Ferrara

et al. 2020

JCM

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“…22 In other neurodegenerative diseases and even mild cognitive disorders, OCTA has been proposed as an additional biomarker for the early diagnosis and disease activity monitoring. 23,24 In this study, we found that ONH microvasculature was somewhat increased compared to the age-matched controls. In many segments, VD was numerically increased in these comparative analyses, although the differences were not statistically signi cant.…”

Section: Discussionmentioning

confidence: 45%

Optic Nerve Head Optical Coherence Tomography Angiography Findings in Patients with Coronavirus Disease 2019

Abrishami

Daneshvar

Emamverdian

et al. 2021

Preprint

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Purpose: To quantify the microvasculature density of the optic nerve head (ONH) using optical coherence tomography angiography (OCTA) analysis.in patients recovered from Coronavirus Disease 2019 (COVID-19) Methods: In a comparative cross-sectional, observational study patients recovered from COVID-19, whom diagnosis of COVID-19 was confirmed by a positive reverse transcription-polymerase chain reaction of a nasopharyngeal sample were included in this study. The. OCTA of ONH was performed at least 2 weeks after recovery from systemic COVID-19. Vascular density (VD) of the all vessels (AV) and small vessels (SV) inside the disc and radial peripapillary capillary (RPC) network density were measured in COVID-19 recovered patients and compared with similar parameters in an age-matched group of normal controls.Results: Twenty-five COVID-19 patients and 22 age-matched normal controls were enrolled in the study and one eye per participant was evaluated. Mean whole image SV VD in the COVID-19 group (49.94 ± 2.22) was not statistically significantly different from that in the control group (49.31 ± 1.93; p-value= 0.308). An increase in RPC VD was found in all AV and SV VD measured, which became statistically significant in whole peripapillary SV VD, peripapillary inferior nasal SV VD, peripapillary inferior temporal SV VD, peripapillary superior nasal SV VD and grid-based AV VD inferior sector (p<0.05 for all comparisons).Conclusion: Unremarkable increase was found in ONH microvasculature in patients who had recovered from COVID-19. These patients may be at risk of ONH vascular complications.

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“…Previous studies have shown that OCT-A is able to detect microvascular retinal alterations and could be useful as a biomarker in the early diagnosis and follow-up of patients affected by different systemic diseases [ 32 , 37 , 53 , 54 ]. However, despite the progress in the diagnosis and the treatment of FD, evidence of correlations of OCTA parameters and systemic findings is low and there are only few studies highlighting such associations [ 31 , 55 ].…”

Section: Discussionmentioning

confidence: 99%

Globotrioasylsphingosine Levels and Optical Coherence Tomography Angiography in Fabry Disease Patients

Wiest

Toro

Nowak

et al. 2021

JCM

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Background: To date, there are no studies associating the dried blood spot (DBS) levels of globotrioasylsphingosine (lysoGb3) with quantitative optical coherence tomography angiography (OCTA) parameters in Fabry disease (FD) patients. Here, we aimed to investigate the association between OCTA vessel density (VD), vessel length density (VLD) with DBS lysoGb3. Methods: A retrospective, single center analysis of all consecutive FD patients enrolled at the Department of Ophthalmology of the University Hospital of Zurich from December 1st, 2017 to September 9th, 2020. An association between VD and VLD detected by OCTA and lysoGb3 was investigated using a linear mixed model. Results: A total of 57 FD patients (23 male, 34 female; 109 eyes) were included. Forty-one patients suffered from the classic phenotype and 16 from the later-onset phenotype. LysoGb3 inversely correlated with VD and VLD in both the superficial (VD: p = 0.034; VLD: p = 0.02) and deep capillary plexus (VD: p = 0.017; VLD: p = 0.018) in the overall FD cohort. Conclusions: Our study shows an association between lysoGb3 and OCTA VD and VLD. This supports the hypothesis that quantitative OCTA parameters might be useful as diagnostic biomarkers for evaluating systemic involvement in FD, and possibly other diseases.

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Optical Coherence Tomography Angiography in Neurodegenerative Disorders

Cited by 50 publications

References 123 publications

Macular Perfusion Impairment in Von Hippel-Lindau Disease Suggests a Generalized Retinal Vessel Alteration

Macular Perfusion Impairment in Von Hippel-Lindau Disease Suggests a Generalized Retinal Vessel Alteration

Optic Nerve Head Optical Coherence Tomography Angiography Findings in Patients with Coronavirus Disease 2019

Globotrioasylsphingosine Levels and Optical Coherence Tomography Angiography in Fabry Disease Patients

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