Optical Coherence Tomography Angiography Findings of Microvascular and Neural Changes in Primary Pulmonary Hypertension

Gu, S. Q.; Li, Zijing; Zhang, Yichi; Liu, Yingmei; Zeng, Peng; Zeng, Rui; Wang, Wenhui; Xiao, Jianhui

doi:10.1097/iae.0000000000002940

Cited by 3 publications

(9 citation statements)

References 29 publications

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“…By the time the loss of vision is obvious, the retinal lesions already worsened with the development of SLE lesions and treatment became relatively difficult. OCTA is used as a non-invasive, time-saving measure that provides detailed information on the perfusion of the ocular vascular network ( 17 ). It shows the microvascular condition without the use of a dye and is a safer screening test for patients.…”

Section: Discussionmentioning

confidence: 99%

Retinal Microvasculature and Conjunctival Vessel Alterations in Patients With Systemic Lupus Erythematosus—An Optical Coherence Tomography Angiography Study

et al. 2021

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Purpose: To evaluate the conjunctival and fundus retinal vessel density in patients with systemic lupus erythematosus (SLE) with optical coherence tomography angiography (OCTA), and to investigate the relationship between vessel density and clinical indicators.Methods: Twelve patients with SLE (24 eyes) and 12 healthy controls (24 eyes) were recruited. OCTA was used to examine the superficial retina layer (SRL) and deep retina layer (DRL) in the macular retina and conjunctival capillary plexus of each eye. We calculated the density of the temporal conjunctival vessels, fundus microvascular (MIR), macrovascular (MAR) and total MIR(TMI) and compared the results in both groups. We used annular partitioning (C1–C6), hemispheric quadrants, and Early Treatment Diabetic Retinopathy Study partitioning (ETDRS) to analyze changes in the retinal vascular density. Correlation analysis was used to investigate the association between blood capillary density and clinical indicators.Results: OCTA results showed significant differences in the conjunctival microvascular density (p < 0.001). There was no significant difference in MIR, TMI, and MAR in the superficial layers between the SLE and healthy group (p > 0.05). The DRL and DTMI (Deeper TMI) densities were decreased in the macular regions of SLE patients (p < 0.05). In the hemispheric segmentation analysis, the superficial MIR was significantly decreased in the IL (inferior left) region of the SLE patients (p < 0.05), and the deep MIR in the IR (inferior right) region was significantly reduced (p < 0.05). In the ETDRS partitioning analysis, the superficial MIR in the inferior, right, and left subdivisions was significantly decreased in the SLE patients (p < 0.05). In the circular segmentation analysis, the deep MIR in the C1 and C3 regions was significantly reduced in SLE patients (p < 0.05), while the superficial MIR density was decreased only in the C3 region (p < 0.05). The conjunctival vascular density was negatively correlated with the STMI (Superficial TMI) (r = −0.5107; p = 0.0108) and DTMI (r = −0.9418, p < 0.0001). There was no significant correlation between vascular density and SLEDAI-2k (Systemic Lupus Erythematosus Disease Activity Index−2000) (P > 0.05).Conclusion: Clinically, patients with SLE and patients suspected of SLE should receive OCTA examination in a comprehensive eye examination to detect changes in ocular microcirculation at an early stage.

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Section: Discussionmentioning

confidence: 99%

Retinal Microvasculature and Conjunctival Vessel Alterations in Patients With Systemic Lupus Erythematosus—An Optical Coherence Tomography Angiography Study

et al. 2021

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“…The difference in the thickness of SFCT in patients with PAH and CTEPH is interesting and may be a result of higher pulmonary arterial blood pressure in the course of PAH, when compared with secondary PH (ocular symptoms are also more common in PAH). 3,29,30 The mean mPaP in PAH patients without eye fundus symptoms described by Gu et al 1 was 53.500 ± 15.464, whereas patients with CTEPH in Cohort 1 of this study had a lower value (32.81 ± 10.39).…”

Section: Discussionmentioning

confidence: 43%

“…20–22 However, no changes were found when the FAZ was assessed in glaucoma and obstructive sleep apnea syndrome or in patients with PAH. 1,23…”

Section: Discussionmentioning

confidence: 99%

“…These include a decrease in the density of vessels of the retinal vascular plexuses and increased choroidal thickness. 1 The increased pressure in the pulmonary artery in the course of CTEPH initially leads to increased pressure in the superior vena cava, then the eyeballs, which causes impairment to retinal and choroidal circulation. A subsequent increase in eye venous pressure effects perfusion and elevates the risk of hypoxia and retinal oedema.…”

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confidence: 99%

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Optical Coherence Tomography Angiography Findings in Patients With Chronic Thromboembolic Pulmonary Hypertension

Krajewski

Turczyńska

Gołębiewska

et al. 2022

Retina

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Purpose: To investigate microvascular changes in the retina and choroid of chronic thromboembolic pulmonary hypertension (CTEPH) patients in comparison with healthy control subjects.Methods: This observational clinical cohort study included 36 CTEPH patients (72 eyes) and 65 healthy control subjects (130 eyes). Optical coherence tomography (OCT) and optical coherence tomography angiography images were obtained from each participant using the AngioVue Imaging System (Optovue, Inc, Freemont, CA).Results: A number of differences were found in the CTEPH cohort, including reductions in mean vessel density at the deep vascular complex of the macula and a reduction in mean subfoveal choroidal thickness. Furthermore, the CTEPH group displayed an increase in foveal avascular zone. The presence of at least one systemic disease, including arterial hypertension, diabetes, chronic coronary syndrome, and/or hyperlipidemia, in CTEPH patients increased the range of vascular complications. The presence of comorbidity was concomitant with a decrease in mean vessel density in the superficial vascular complex of the macula, excluding the fovea, and a decrease in mean vessel density in the radial peripapillary capillary plexus.Conclusion: Measurements of the foveal avascular zone and vessel density of the DVC and subfoveal choroidal thickness may be useful and sensitive predictors of retinal and choroidal circulation impairment in CTEPH patients without systemic disease.

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“…FLV was significantly higher in DR patients than in control group [ 21 ] and was an independent predictor of diabetic peripheral neuropathy [ 18 ]. In addition, changes in GCC parameters have been found in patients with systemic diseases such as chronic kidney disease [ 22 ], Alzheimer’s disease [ 23 ] and primary pulmonary hypertension [ 24 ], which may provide useful evidence for early detection of retinal nerve damage. Therefore, GCC parameters are considered to be the most sensitive indicators of any adverse factors affecting the retina [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Changes of retinal ganglion cell complex after vitrectomy in rhegmatogenous retinal detachment patients and its correlation with inflammatory blood biomarkers

et al. 2022

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Purpose To compare retinal ganglion cell complex (GCC) parameters between rhegmatogenous retinal detachment (RRD) eyes and normal contralateral eyes after vitrectomy and to evaluate their correlation with inflammatory blood markers. Methods We investigated 25 eyes that underwent vitrectomy due to RRD. Venous blood samples were collected from all participants before 08:00 a.m. on the second day of admission after a 12-hour fast for blood counts. The differences of retinal structure between RRD and contralateral eyes were compared 1 week postoperatively. Results Focal loss volume (FLV) (2.009 ± 1.286)% was significantly increased compared with the contralateral eyes (p < 0.001). Monocyte-to-high-density lipoprotein was significantly positively correlated with GCC thickness parameters, and negatively correlated with FLV and global loss volume (GLV). Postoperative best-corrected visual acuity was negatively correlated with GLV (p = 0.039, R2 = 0.172). Conclusion Retinal ganglion cells (RGCs) loss might present early postoperatively in RRD eyes, and was associated with systemic inflammation. RGCs loss might affect postoperative vision.

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Optical Coherence Tomography Angiography Findings of Microvascular and Neural Changes in Primary Pulmonary Hypertension

Cited by 3 publications

References 29 publications

Retinal Microvasculature and Conjunctival Vessel Alterations in Patients With Systemic Lupus Erythematosus—An Optical Coherence Tomography Angiography Study

Retinal Microvasculature and Conjunctival Vessel Alterations in Patients With Systemic Lupus Erythematosus—An Optical Coherence Tomography Angiography Study

Optical Coherence Tomography Angiography Findings in Patients With Chronic Thromboembolic Pulmonary Hypertension

Changes of retinal ganglion cell complex after vitrectomy in rhegmatogenous retinal detachment patients and its correlation with inflammatory blood biomarkers

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