Optical coherence tomography and visual evoked potentials: which is more sensitive in multiple sclerosis?

Maggio, G. Di; Santangelo, Roberto; Guerrieri, Simone; Bianco, Mariangela; Ferrari, Laura De; Medaglini, S.; Rodegher, Mariaemma; Colombo, Bruno; Moiola, Lucia; Chieffo, Raffaella; Carro, Ubaldo Del; Martinelli, Vittorio; Comi, Giancarlo; Leocani, Letizia

doi:10.1177/1352458514524293

Cited by 67 publications

(59 citation statements)

References 30 publications

(33 reference statements)

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“…12,13 Our VEP results are also similar to a prior study in which in 48 of the 85 (56%) pediatric patients with MS demonstrated VEP prolongation more than 2.5 SDs beyond control mean latencies and/or reduced amplitudes. 2 Also in line with our findings, another study of 14 pediatric patients with MS reported no difference in VEP latencies between MS-ON eyes and MS non-ON eyes ( p = 0.524) or between MS-ON eyes and MS fellow eyes ( p = 0.654).…”

Section: Discussionsupporting

confidence: 89%

Optical coherence tomography and visual evoked potentials in pediatric MS

Waldman

Liu

Lavery

et al. 2017

Neurol Neuroimmunol Neuroinflamm

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Objective:To determine the relative ability of optical coherence tomography (OCT) and pattern-reversal visual evoked potentials (pVEPs) to detect visual pathway involvement in pediatric-onset MS.Methods:Pediatric-onset MS participants (onset <18 years) and healthy controls (HCs) underwent OCT (Cirrus HD-OCT) and pVEPs. Retinal nerve fiber layer (RNFL), ganglion cell layer to inner plexiform layer (GCL-IPL), and P100 pVEP latency were measured. Generalized estimating equation models were used to compare the groups, adjusting for age and intereye correlations.Results:Twenty-four pediatric MS participants, 14 with a history of remote (>6 months) optic neuritis (ON) in one eye (8 participants) or both the eyes (6 participants), and 24 HCs were enrolled. RNFL thinning (<83 μm, 2 SDs below HC eyes) occurred in 50% of ON eyes vs 5% of non-ON eyes. Prolonged VEP latency (>109 msec) occurred in 58% of ON eyes and 55% of non-ON eyes. A clinical history of ON predicted RNFL (p < 0.001) and GCL-IPL thinning (p = 0.011), whereas prolonged pVEP latency in children with MS occurred independent of ON history.Conclusions:OCT and pVEPs provide complementary but distinct insights. OCT is sensitive to retinal changes in the context of clinical ON, whereas pVEPs are useful to detect disseminated lesions of the visual pathway in children with MS.

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Section: Discussionsupporting

confidence: 89%

Optical coherence tomography and visual evoked potentials in pediatric MS

Waldman

Liu

Lavery

et al. 2017

Neurol Neuroimmunol Neuroinflamm

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“…There are studies that find both of these methods to be helpful for subclinical involvement detection (Trip et al, 2005;Fisher et al, 2006; Klistorner et al, 2008;Naismith et al, 2009;Talman et al, 2010). Our study showed significant correlation between RNFLT with mean VEP amplitude and latency, as previously observed (Naismith et al, 2009;Di Maggio et al, 2014). However, a few authors have described a relationship between RNFLT and P 100 latency, (Fatehi et al, 2012), and with N75/P 100 latency (Trip et al, 2005).…”

supporting

confidence: 81%

“…We found a significant positive correlation between RNFLT and mean N75/P100 amplitude in patients without ON (r s = 0.43; p < 0.001), and after ON (r s = 0.45; p < 0.001). Both in patients without p < 0.001) (Di Maggio et al 2014). Afferent visual pathways represent an acute demyelination episode through acute ON, while in the case of chronic, subclinical retinopathy and optic neuropathy -diffuse, chronic central nervous system damage.…”

mentioning

confidence: 89%

“…MS often affects visual pathways, as almost 70% of MS patients will experience an optic neuritis (ON) episode in their lifetime (Di Maggio et al 2014). Afferent visual pathways represent an acute demyelination episode through acute ON, while in the case of chronic, subclinical retinopathy and optic neuropathy -diffuse, chronic central nervous system damage.…”

Section: Functional and Structural Evaluation Of Afferent Visual Systmentioning

confidence: 99%

See 1 more Smart Citation

Functional and Structural Evaluation of Afferent Visual System in Multiple Sclerosis Patients / Funkcionālas un Strukturālas Redzes Sistēmas Izmaiņas Multiplās Sklerozes Pacientiem

Pastare

Ķire

Erts

et al. 2015

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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There is insufficient information about the progress and variability of multiple sclerosis (MS). Afferent visual pathways are an appropriate MS clinical model. Optical coherence tomography (OCT) allows to perform precise measurements of axonal tissue in the retinal nerve fibre layer (RNFL). Visual evoked potentials (VEP) provide information about the functional status of visual pathways. The aim of our study was to use OCT and VEP to evaluate MS patients with and without optic neuritis (ON) history and to determine relationships between functional and structural changes. The cross-sectional study included 76 relapsing-remitting MS patients and 28 healthy controls. The lowest mean VEP N75/P100 amplitude was found in ON affected eyes (8.16 mkV, SD = 4.60). However, it was observed that the mean amplitude in patients without ON (M = 9.86; SD = 4.63) was by 4.64 mkV lower than in controls (p < 0.001). Similarly, the mean P 100 latency in ON eyes was 9.26 ms longer than in eyes of patients without ON history (p < 0.01). RNFL in the temporal segment (RNFLT) was the thinnest in ON eyes, and even in patient eyes without ON, it was thinner than in controls. We found a significant positive correlation between RNFLT and mean N75/P100 amplitude in patients without ON (r s = 0.43; p < 0.001), and after ON (r s = 0.45; p < 0.001). Both in patients without p < 0.001) (Di Maggio et al. 2014). Afferent visual pathways represent an acute demyelination episode through acute ON, while in the case of chronic, subclinical retinopathy and optic neuropathy -diffuse, chronic central nervous system damage. For better understanding of MS, recently a new biological marker was proposed -optical coherence tomography (OCT), which allows to perform precise measurements of retinal axonal tissue in the retinal nerve fiber layer (RNFL). Visually evoked potentials (VEP) provide information about functional status of visual pathways.The aim of our study was to use VEP and OCT to evaluate MS patients with and without ON history and to determine relationships between functional and structural changes. MATERIALS AND METHODSThe cross-sectional study included 76 relapsing-remitting MS patients who were divided into two groups:-MS patients without ON symptoms in history; -MS patients with ON history.In the MS patient group with ON history, ON-affected eyes (ON+) and contralateral, ON-unaffected eyes (ON-) were analysed separately The control group included 28 age-matched and sexmatched healthy individuals. -refraction disorders exceeding ± 6 diopters;-other neurological and ophthalmic diseases, which could affect the afferent visual system; -inability to participate in visual system examinations.A history of ON was determined on the basis of symptoms and clinical signs (Voss et al., 2011). Neurological examination of patients with disability was assessed using the Kurzke Expanded Disability Status Scale (EDSS). In clinical assessment of the ophthalmological condition, the following functional and structural visual system tests were made separatel...

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“…Thus, any diagnostic model being developed should prioritize OCT measures as critical and visual function measures as enhancing the model. Based on previous studies that demonstrated RNFL thickness and visual evoked potentials (VEP) have similar sensitivities in optic neuritis eyes, it may be interesting to include VEP in a future diagnostic model with GCIP thickness and/or PMB thickness …”

Section: Discussionmentioning

confidence: 99%