Optical and X-ray attenuation properties of hafnium oxide nanoparticles surface functionalized with fucoidan: toward the early diagnosis of atherothrombotic diseases

Sebti, Yasmine; Aid‐Launais, Rachida; Geinguenaud, Frédéric; Chalal, Mohand; Lalatonne, Yoann; Chaubet, Fréderic; Ou, Phalla; Motte, Laurence

doi:10.1039/d2ma01026g

Cited by 3 publications

(4 citation statements)

References 70 publications

(107 reference statements)

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“…Hafnium nanoparticles have also been used for imaging of cardiovascular disease. Sebti et al 114 fabricated hafnium oxide nanoparticle coated with fucoidan, a sulfated polysaccharide with high affinity for P-selectin. Activated platelets that participate in atherothrombosis express P-selectin on their surface.…”

Section: Applications In Imagingmentioning

confidence: 99%

“…Hafnium-based nanomaterials can be designed to exhibit properties advantageous to a broad range of applications such as therapy radiosensitizers, ,,,,− X-ray-based imaging contrast agents, − ,− , sensor components, ,,− semiconductors, ,− ferroelectrics, − and optical device components. ,, As such, appropriate characterization methodology conducive to preparing materials with the relevant properties for each application is critical. Nanomaterial morphology encompasses particle size, shape, and composition .…”

Section: Characterization and Morphologymentioning

confidence: 99%

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Synthesis and Bioapplication of Emerging Nanomaterials of Hafnium

Skrodzki,

Molinaro,

Brown

et al. 2024

ACS Nano

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A significant amount of progress in nanotechnology has been made due to the development of engineered nanoparticles. The use of metallic nanoparticles for various biomedical applications has been extensively investigated. Biomedical research is highly focused on them because of their inert nature, nanoscale structure, and similar size to many biological molecules. The intrinsic characteristics of these particles, including electronic, optical, physicochemical, and surface plasmon resonance, that can be altered by altering their size, shape, environment, aspect ratio, ease of synthesis, and functionalization properties, have led to numerous biomedical applications. Targeted drug delivery, sensing, photothermal and photodynamic therapy, and imaging are some of these. The promising clinical results of NBTXR3, a high-Z radiosensitizing nanomaterial derived from hafnium, have demonstrated translational potential of this metal. This radiosensitization approach leverages the dependence of energy attenuation on atomic number to enhance energy−matter interactions conducive to radiation therapy. High-Z nanoparticle localization in tumor issue differentially increases the effect of ionizing radiation on cancer cells versus nearby healthy ones and mitigates adverse effects by reducing the overall radiation burden. This principle enables material multifunctionality as contrast agents in X-ray-based imaging. The physiochemical properties of hafnium (Z = 72) are particularly advantageous for these applications. A well-placed K-edge absorption energy and high mass attenuation coefficient compared to elements in human tissue across clinical energy ranges leads to significant attenuation. Chemical reactivity allows for variety in nanoparticle synthesis, composition, and functionalization. Nanoparticles such as hafnium oxide exhibit excellent biocompatibility due to physiochemical inertness prior to incidence with ionizing radiation. Additionally, the optical and electronic properties are applicable in biosensing, optical component coatings, and semiconductors. The wide interest has prompted extensive research in design and synthesis to facilitate property fine-tuning. This review summarizes synthetic methods for hafnium-based nanomaterials and applications in therapy, imaging, and biosensing with a mechanistic focus. A discussion and future perspective section highlights clinical progress and elaborates on current challenges. By focusing on factors impacting applicational effectiveness and examining limitations this review aims to support researchers and expedite clinical translation of future hafnium-based nanomedicine.

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Section: Applications In Imagingmentioning

confidence: 99%

Section: Characterization and Morphologymentioning

confidence: 99%

Synthesis and Bioapplication of Emerging Nanomaterials of Hafnium

Skrodzki,

Molinaro,

Brown

et al. 2024

ACS Nano

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“…The specific targeting of functionalized NPs to the target cell type along with good biocompatibility and better X-ray attenuation when compared to unmodified and citrate-modified counterparts, suggests a great potential of the designed formulation as an X-ray contrast agent for diagnosing atherothrombosis. 101 While in another study ultra-small (5 nm) HfO 2 NPs were employed to assess bone microdamage, which is traditionally evaluated using invasive histomorphometry (Fig. 7A-J).…”

Section: Hafnium/hafnia (72) Nanoparticlesmentioning

confidence: 99%

High atomic number nanoparticles to enhance spectral CT imaging aspects

Mutreja,

Maalej,

Kaushik

et al. 2023

Mater. Adv.

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“…Hafnium oxide nanocrystals are particularly interesting since they are relevant for memory devices, − as X-ray CT contrast agents, − for scintillators, ,, for catalysis, or for radiotherapy . While HfO 2 can be synthesized in benzyl alcohol from HfCl 4 in a pressure bomb (autoclave), the reaction can also be performed in a microwave reactor, considerably shortening the reaction time to 3–4 h .…”

Section: Introductionmentioning

confidence: 99%

From Gel to Crystal: Mechanism of HfO₂ and ZrO₂ Nanocrystal Synthesis in Benzyl Alcohol

Goossens,

Aalling-Frederiksen,

Tack

et al. 2024

J. Am. Chem. Soc.

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Nonaqueous sol−gel syntheses have been used to make many types of metal oxide nanocrystals. According to the current paradigm, nonaqueous syntheses have slow kinetics, thus favoring the thermodynamic (crystalline) product. Here we investigate the synthesis of hafnium (and zirconium) oxide nanocrystals from the metal chloride in benzyl alcohol. We follow the transition from precursor to nanocrystal through a combination of rheology, EXAFS, NMR, TEM, and X-ray total scattering (PDF analysis). Upon dissolving the metal chloride precursor, the exchange of chloride ligands for benzylalkoxide liberates HCl. The latter catalyzes the etherification of benzyl alcohol, eliminating water. During the temperature ramp to the reaction temperature (220 °C), sufficient water is produced to turn the reaction mixture into a macroscopic gel. Rheological analysis shows a network consisting of strong interactions with temperature-dependent restructuring. After a few minutes at the reaction temperature, crystalline particles emerge from the gel, and nucleation and growth are complete after 30 min. In contrast, 4 h are required to obtain the highest isolated yield, which we attribute to the slow in situ formation of water (the extraction solvent). We used our mechanistic insights to optimize the synthesis, achieving high isolated yields with a reduced reaction time. Our results oppose the idea that nonaqueous sol−gel syntheses necessarily form crystalline products in one step, without a transient, amorphous gel state.

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Optical and X-ray attenuation properties of hafnium oxide nanoparticles surface functionalized with fucoidan: toward the early diagnosis of atherothrombotic diseases

Abstract: Atherothrombosis is the main cause of death worldwide. An early diagnosis of this pathology is necessary to avoid serious clinical events. In this study, we report hafnium oxide nanoparticles (HfO2...

Cited by 3 publications

References 70 publications

Synthesis and Bioapplication of Emerging Nanomaterials of Hafnium

Synthesis and Bioapplication of Emerging Nanomaterials of Hafnium

High atomic number nanoparticles to enhance spectral CT imaging aspects

From Gel to Crystal: Mechanism of HfO₂ and ZrO₂ Nanocrystal Synthesis in Benzyl Alcohol

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Optical and X-ray attenuation properties of hafnium oxide nanoparticles surface functionalized with fucoidan: toward the early diagnosis of atherothrombotic diseases

Abstract: Atherothrombosis is the main cause of death worldwide. An early diagnosis of this pathology is necessary to avoid serious clinical events. In this study, we report hafnium oxide nanoparticles (HfO2...

Cited by 3 publications

References 70 publications

Synthesis and Bioapplication of Emerging Nanomaterials of Hafnium

Synthesis and Bioapplication of Emerging Nanomaterials of Hafnium

High atomic number nanoparticles to enhance spectral CT imaging aspects

From Gel to Crystal: Mechanism of HfO2 and ZrO2 Nanocrystal Synthesis in Benzyl Alcohol

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From Gel to Crystal: Mechanism of HfO₂ and ZrO₂ Nanocrystal Synthesis in Benzyl Alcohol