Optic Nerve Hypoplasia, Big Discs, Large Cupping, and Vascular Brain Malformation Embolized: 22 Years of Follow-up

Congenital Optic Nerve Anomalies

“…1 Interestingly, megalopapilla has been reported to occur simultaneously with ONH, suggesting prenatal loss of optic nerve axons may not alter the genetically predetermined size of scleral canals. 231,232 Rare cases of megalopapilla with basal encephalocele exist and are associated with midfacial anomalies. 226 Patients with megalopapilla should be screened for normal-tension glaucoma.…”

Congenital Optic Nerve Anomalies

“…1 Interestingly, megalopapilla has been reported to occur simultaneously with ONH, suggesting prenatal loss of optic nerve axons may not alter the genetically predetermined size of scleral canals. 231,232 Rare cases of megalopapilla with basal encephalocele exist and are associated with midfacial anomalies. 226 Patients with megalopapilla should be screened for normal-tension glaucoma.…”

Large Cups in Normal-Sized Optic Discs

“…A small optic disc size is not a prerequisite for ONH.33 It has been demonstrated that ONH might be associated with large optic discs and large cups. 31,35 The term hypoplasia means "incomplete develop¬ ment or underdevelopment," according to Dorland's Medi¬ cal Dictionary™ and to Robins' Pathologic Basis of Dis¬ ease. 17 Consequently, any prenatal, perinatal, or postnatal lesion affecting the number of retinal ganglion cells be¬ fore the system is fully developed (about the age of 1 year) should strictly be referred to as hypoplasia and not at¬ rophy.…”

Congenital Optic Nerve Anomalies

“…1 Interestingly, megalopapilla has been reported to occur simultaneously with ONH, suggesting prenatal loss of optic nerve axons may not alter the genetically predetermined size of scleral canals. 231,232 Rare cases of megalopapilla with basal encephalocele exist and are associated with midfacial anomalies. 226 Patients with megalopapilla should be screened for normal-tension glaucoma.…”

Large Cups in Normal-Sized Optic Discs

“…A small optic disc size is not a prerequisite for ONH.33 It has been demonstrated that ONH might be associated with large optic discs and large cups. 31,35 The term hypoplasia means "incomplete develop¬ ment or underdevelopment," according to Dorland's Medi¬ cal Dictionary™ and to Robins' Pathologic Basis of Dis¬ ease. 17 Consequently, any prenatal, perinatal, or postnatal lesion affecting the number of retinal ganglion cells be¬ fore the system is fully developed (about the age of 1 year) should strictly be referred to as hypoplasia and not at¬ rophy.…”

Congenital Optic Nerve Anomalies

“…1 Interestingly, megalopapilla has been reported to occur simultaneously with ONH, suggesting prenatal loss of optic nerve axons may not alter the genetically predetermined size of scleral canals. 231,232 Rare cases of megalopapilla with basal encephalocele exist and are associated with midfacial anomalies. 226 Patients with megalopapilla should be screened for normal-tension glaucoma.…”

Large Cups in Normal-Sized Optic Discs

“…A small optic disc size is not a prerequisite for ONH.33 It has been demonstrated that ONH might be associated with large optic discs and large cups. 31,35 The term hypoplasia means "incomplete develop¬ ment or underdevelopment," according to Dorland's Medi¬ cal Dictionary™ and to Robins' Pathologic Basis of Dis¬ ease. 17 Consequently, any prenatal, perinatal, or postnatal lesion affecting the number of retinal ganglion cells be¬ fore the system is fully developed (about the age of 1 year) should strictly be referred to as hypoplasia and not at¬ rophy.…”