Optic Nerve Head Measurements With Optical Coherence Tomography: A Phantom-Based Study Reveals Differences Among Clinical Devices

Agrawal, Anant; Baxi, Jigesh; Calhoun, William; Chen, Chieh Li; Ishikawa, Hiroshi; Schuman, Joel S.; Wollstein, Gadi; Hammer, Daniel X.

doi:10.1167/iovs.15-18738

Cited by 15 publications

(13 citation statements)

References 18 publications

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“…Previous studies have highlighted that these differences are likely to be due to both the instruments internal algorithms as well as scan patterns. [ 29 , 30 ] Spectralis derived optic disc measurements consistently produced the weakest correlations and the greatest number of outliers with beta PPA being a main contributing factor. Analysis of these outliers showed that variations in disc area measurements between the two instruments resulted from markedly different delineation of the BMO location in the areas of beta PPA ( Fig 3B ).…”

Section: Discussionmentioning

confidence: 96%

The impact of optic nerve and related characteristics on disc area measurements derived from different imaging techniques

et al. 2018

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PurposeOptic nerve head (ONH) assessment and its interpretation in healthy patients and those with glaucoma remains a pivotal topic specifically considering rapid advancements in imaging technologies. We undertook a large-scale, mixed cohort, comparative study to assess the correlation of optic disc measurements between different imaging modalities and investigated the impact of patient and disc associated parameters.MethodsONH sizes were obtained from one randomly selected eye of each of 209 patients using stereophotography, confocal scanning laser ophthalmoscopy and two different optical coherence tomographers (OCT). Patient related data, glaucoma status and optic disc variables, specifically oblique insertion, torsion, presence of beta PPA and spherical equivalent were recorded. Measurements between imaging modalities were analysed using Pearson correlation, linear regression analysis and Blend-Altman plots. Individual variables were compared applying multivariate regression analysis, ANOVA and chi square statistics was used to determine correlations between patient and clinical characteristics.ResultsAbsolute measurements significantly differed between imaging modalities generally producing smaller measurements for OCT derived measurements of Bruch’s membrane opening (BMO). Pairwise correlations between imaging modalities were between 0.83 and 0.93 for discs without myopia, oblique insertion, or beta PPA. These features impacted on measurements for individual modalities and consequently contributed to inconsistencies and variability.ConclusionIn comparison to planimetry, OCT derived BMO measurements are more variable in the presence of oblique insertion, beta PPA or magnification errors due to myopia. Impact of these factors, however, differs between instruments and needs to be considered to accurately interpret optic disc features in particular within the context of glaucoma diagnosis.

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Section: Discussionmentioning

confidence: 96%

The impact of optic nerve and related characteristics on disc area measurements derived from different imaging techniques

et al. 2018

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“…However, literature has shown that OCT data from the leading OCT brands are comparable. [25][26][27] Several studies have looked at the optic disc size of people across races. One of the key differences highlighted is the larger optic disc size in people of African descent.…”

Section: Discussionmentioning

confidence: 99%

Optic disc morphometry using spectral domain optical coherence tomography in a Nigerian population

Awe

Onakpoya

Adeoye

2021

European Journal of Ophthalmology

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Purpose: To assess morphological optic disc dimensions using spectral-domain optical coherence tomography (OCT) in a Nigerian population. Materials and method: Good quality SD-OCT scans of the optic disc of 147 eyes of 88 participants were selected, enrolled, and retrospectively reviewed. All subjects had optic nerve head and retinal nerve fibre layer OCT imaging, as well as analysis, done using the Topcon 3D OCT-1 Maestro®. The age, sex, and some OCT-generated optic disc dimensions namely disc area (DA), vertical disc diameter (VDD), horizontal disc diameter (HDD) were retrieved from the database and analyzed. Results: The mean age of the study subjects was 52.6±20.9 years with a range of 8–90 years; male to female ratio was 1:1.3. The right eye and left eye accounted for 75 and 72 of the 147 scans respectively. The mean DA, VDD, and HDD were 2.54 ± 0.48 mm2, 1926.5 ± 189.6 μm and 1673.9 ± 173.9 μm, respectively. Males had significantly larger DA than females (2.56 ± 0.53 mm2 vs 2.51 ± 0.44 mm2, p = 0.043). The mean DA and VDD of eyes of subjects aged 21–40 years were significantly higher compared to subjects aged 60 years and more ( p = 0.008 and 0.001, respectively). Conclusion: The mean optic disc area and diameters are larger than those reported in similar studies involving blacks and other races. The mean disc area reduces with increasing age.

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“…Differences in the mean RNFL thickness between Stratus and Spectralis OCT (106.2 ± 6.9 µm vs 100.0 ± 7.3 µm) have been reported, and concluded not to be interchangeable in a clinical evaluation [6]. Agrawal et al showed that built-in algorithms may be the main cause for differences in the measured layer thicknesses [9]. A reported mean difference between Spectralis and Cirrus devices RNFL thicknesses was 6.7 µm, when device's own software was used, and the thickness difference was reduced to 0.1 µm when custom software was used [5].…”

Section: Discussionmentioning

confidence: 99%

“…Unfortunately, current commercial OCT devices have a poor inter-brand repeatability regarding the assessment of the retinal layers, limiting the interchangeable use of different devices. Differences between devices have been observed both in human eyes [1][2][3][4][5][6][7] and in specially developed phantom eyes [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

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Testing a phantom eye under various signal-to-noise ratio conditions using eleven different OCT devices

Heikka¹,

Ometto²,

Montesano³

et al. 2020

Biomed. Opt. Express

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We compared eleven OCT devices in their ability to quantify retinal layer thicknesses under different signal-strength conditions, using a commercially available phantom eye. We analyzed a medium-intensity 50 µm layer in an identical manner for all devices, using the provided log-scale images and a reconstructed linear-scale tissue reflectivity metric. Thickness measurements were highly comparable when the data were analyzed in an identical manner. With optimal signal strength, the thickness of the 50 µm layer was overestimated by a mean of 4.3 µm in the log-scale images and of 2.7 µm in the linear-scale images.

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Optic Nerve Head Measurements With Optical Coherence Tomography: A Phantom-Based Study Reveals Differences Among Clinical Devices

Cited by 15 publications

References 18 publications

The impact of optic nerve and related characteristics on disc area measurements derived from different imaging techniques

The impact of optic nerve and related characteristics on disc area measurements derived from different imaging techniques

Optic disc morphometry using spectral domain optical coherence tomography in a Nigerian population

Testing a phantom eye under various signal-to-noise ratio conditions using eleven different OCT devices

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