Opsoclonus-Myoclonus-Ataxia Syndrome Related to the Novel Coronavirus (COVID-19)

Sanguinetti, Shayna; Ramdhani, Ritesh A.

doi:10.1097/wno.0000000000001129

Cited by 32 publications

(33 citation statements)

References 7 publications

(8 reference statements)

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“…The phenomenology of myoclonus as an immunemediated condition by SARS-CoV-2 seems to be quite homogenous. Indeed, like our, patients presented with generalized myoclonus, predominantly action induced, involving trunk and the limbs [3][4][5][6] and accompanied in some cases, by cerebellar signs [1,7] or opsoclonus [8,9]). In the case described here, a brainstem reticular generator seems to be more likely according to the involvement of the axial muscles, the presence of a startle phenomenon, the normality of the EEG, the absence of a C reflex, and the lack of response to symptomatic treatment by levetiracetam.…”

Section: Discussionsupporting

confidence: 72%

Isolated generalized myoclonus immune-mediated by SARS-CoV-2: an illustrative videotaped case

Otmani

Moutaouakil

Ouazzani³

et al. 2021

Neurol Sci

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Myoclonus in the context of COVID-19 is an increasingly recognized condition. The occurrence in an ICU context in hypoxic patients, with metabolic disorders, taking several types of medication, makes difficult to establish a precise cause. Also, the implication of SARS-CoV-2 by direct invasion of the CNS or by immune-mediated phenomena is not yet clear. Currently, a dozen of cases of myoclonus as a predominant clinical manifestation, immune-mediated by SARS-Cov-2 are published. In all these cases, myoclonus was preceded by respiratory or other suggestive symptoms (e.g., anosmia) for this infection making straightforward the causal link. We describe a case of an isolated generalized myoclonus without other clinical complaints nor chest CT scan abnormalities nor SARS-CoV-2 RNA detection on nasopharyngeal swabs and on the CSF, as a para-infectious phenomenon of COVID-19 infection with excellent response to steroids perfusion. This challenging diagnosis was made upon confirmation of seroconversion (serology was negative at admission, then positive for IgM at day 6, then for both IgM and IgG at day 10) underlying that repeating serology is a diagnostic key to capture a similar findings. Supplementary Information The online version contains supplementary material available at 10.1007/s10072-021-05164-8.

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Section: Discussionsupporting

confidence: 72%

Isolated generalized myoclonus immune-mediated by SARS-CoV-2: an illustrative videotaped case

Otmani

Moutaouakil

Ouazzani³

et al. 2021

Neurol Sci

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“…Etiologies include toxins, paraneoplastic syndromes and post infectious 2 . Our Case in an infant corroborates two reports associating opsoconus-myoclonus syndrome (OMS) with COVID-19 in older patients 3 , 4 .…”

supporting

confidence: 91%

Opsoclonus After COVID-19 in an Infant

Heald

Devine

Smith

et al. 2021

Pediatric Neurology

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“…Myoclonus is defined as a sudden, brief, “shock-like”, nonepileptic involuntary movement [ 9 ], which has been described as a symptom of SARS-CoV-2 infection [ 10 ]. Opsoclonus-Myoclonus-Ataxia syndrome (OMAS) associated COVID-19 infection has been reported recently [ 11 12 ].…”

mentioning

confidence: 99%

“…Opsoclonus-Myoclonus-Ataxia syndrome (OMAS) associated COVID-19 infection has been reported recently [ 11 12 ].…”

mentioning

confidence: 99%

Opsoclonus-Myoclonus-Ataxia Syndrome (OMAS) Associated with SARS-CoV-2 Infection: Post-Infectious Neurological Complication with Benign Prognosis

Urrea-Mendoza¹,

Okafor²,

Ravindran³

et al. 2021

Tremor and Other Hyperkinetic Movements

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The novel coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) is the cause of the COVID-19 pandemic [ 5 ]. SARS-Cov-2 demonstrates partial resemblance to SARS-CoV and MERS-CoV in phylogenetic analysis, clinical manifestations, and pathological findings [ 6 , 7]. Reports emerging from China have described ataxia as a neurological symptom of the SARS-CoV-2 infection [ 5 ]. Opsoclonus consists of back-to-back multidirectional conjugate saccades without an inter-saccadic interval [ 8 ]. Myoclonus is defined as a sudden, brief, “shock-like”, nonepileptic involuntary movement [ 9 ], which has been described as a symptom of SARS-CoV-2 infection [ 10 ]. Opsoclonus-Myoclonus-Ataxia syndrome (OMAS) associated COVID-19 infection has been reported recently [ 11 12 ].

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Opsoclonus-Myoclonus-Ataxia Syndrome Related to the Novel Coronavirus (COVID-19)

Abstract: Supplemental Digital Content is Available in the Text.

Cited by 32 publications

References 7 publications

Isolated generalized myoclonus immune-mediated by SARS-CoV-2: an illustrative videotaped case

Isolated generalized myoclonus immune-mediated by SARS-CoV-2: an illustrative videotaped case

Opsoclonus After COVID-19 in an Infant

Opsoclonus-Myoclonus-Ataxia Syndrome (OMAS) Associated with SARS-CoV-2 Infection: Post-Infectious Neurological Complication with Benign Prognosis

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