Opsins and gonadal circadian rhythm in the swordfish (Xiphias gladius) ovary: Their potential roles in puberty and reproductive seasonality

Basili, Danilo; Gioacchini, Giorgia; Todisco, Vittoria; Candelma, Michela; Marisaldi, Luca; Pappalardo, Luigi; Carnevali, Oliana

doi:10.1016/j.ygcen.2020.113707

Cited by 5 publications

(5 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sleep behavior, regulated by the summation of circadian rhythms and homeostasis, should be considered when assessing the environmental risk of psychoactive substances. The circadian rhythm disorders in fish species posed by psychoactive substances (e.g., CF and KET) pouring into aquatic system should be a concern [ 76 ]. The results of the present experiments demonstrate that the duration of fish immobility during the dark period can efficiently reflect the phenotype of the alterations in sleep state induced by a combination of CF and KET, consistent with previously proposed criteria [ 49 ].…”

Section: Resultsmentioning

confidence: 99%

Antagonistic interaction between caffeine and ketamine in zebrafish: Implications for aquatic toxicity

Wang,

Xu,

2024

Environmental Science and Ecotechnology

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Antagonistic interaction between caffeine and ketamine in zebrafish: Implications for aquatic toxicity

Wang,

Xu,

2024

Environmental Science and Ecotechnology

View full text Add to dashboard Cite

“…TIPIN is part of the replisome complex and binds the replication fork-protection complex TIMELESS, which is involved in circadian rhythm regulation ( 47 ). Circadian rhythms are well known to play key roles in animal reproduction ( 48 ). The existing body of research suggests that during the chronotype and the circadian timekeeping system change during the puberty, including endogenous rhythm period and sensitivity to environmental time cues ( 49 ).…”

Section: Discussionmentioning

confidence: 99%

Identifying Environmental Endocrine Disruptors Associated With the Age at Menarche by Integrating a Transcriptome-Wide Association Study With Chemical-Gene-Interaction Analysis

Feng

Qin

et al. 2022

Front. Endocrinol.

View full text Add to dashboard Cite

Menarche is the first occurrence of menstrual bleeding and one of the most important events of female puberty. Alarmingly, over the last several decades, the mean age at menarche (AAM) has decreased. Environmental endocrine disruptors (EEDs) are chemicals that may interfere with the endocrine system, resulting in adverse developmental, immunological, neurological, and reproductive effects in humans. Thus, the effects of EEDs on fertility and reproduction are growing concerns in modern societies. In this study, we aimed to determine the influence of genetic and environmental factors on AAM. We used data from an AAM genome-wide association study of 329,345 women to conduct a transcriptome-wide association study (TWAS) with FUSION software. As references, we determined the gene-expression levels in the hypothalamus, pituitary gland, ovaries, uterus, and whole blood. We performed Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses using the significantly dysregulated genes identified by the TWAS. Using the STRING database, we also generated a protein–protein-interaction network to analyze common AAM-specific genes identified by the TWAS with different tissues. We performed chemical-related gene set enrichment analysis (CGSEA) and identified significant TWAS genes to uncover relationships between different chemicals and AAM. The TWAS identified 9,848 genes; among these, 1580 genes were significant (P < 0.05), and 11 genes were significant among the hypothalamus, pituitary, ovary, uterus, and whole blood. CGSEA identified 1,634 chemicals, including 120 chemicals significantly correlated with AAM. In summary, we performed a TWAS (for genetic factors) and CGSEA (for environmental factors) focusing on AAM and identified several AAM-associated genes and EEDs. The results of this study expand our understanding of genetic and environmental factors related to the onset of female puberty.

show abstract

“…Liver samples were collected from swordfish females already caught and analyzed in previous studies using different approaches and for different purposes [3,4,9] (Table S1). Briefly, the animals were caught by commercial long-liners in the central and western Mediterranean Sea.…”

Section: Sample Collectionmentioning

confidence: 99%

“…The lower jaw to fork length (LJFL) (min = 97 cm; max = 190 cm) and total weight (TW) (min = 8 kg; max = 90 kg) were recorded for each specimen. Repro-ductive status of females was previously determined by histological analysis [3,4,9], and 22 immature and 28 mature females were included in this study. The samples were collected following the guidelines of the International Commission for the Conservation of Atlantic Tuna (ICCAT).…”

Section: Sample Collectionmentioning

confidence: 99%

“…Recently, RNA-seq was widely applied in several studies for the conservation and preservation of the fisheries resource, investigating genes involved in adaptation to environmental changes [7,8]. Notably, swordfish ovarian and liver transcriptome analysis was performed [4,9]. In particular, the transcriptome of ovaries from mature and immature females, caught in the breeding season, were investigated in order to identify and characterize the molecular network involved in sexual maturity and in the circadian rhythm.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Window of Vulnerability: Chronic Environmental Stress Does Not Impair Reproduction in the Swordfish Xiphias gladius

Gioacchini

Filippi

Debernardis

et al. 2023

Animals

Self Cite

View full text Add to dashboard Cite

Xiphias gladius is an important fishing resource. The Mediterranean stock is affected by overfishing and is declining. In this light, the aim of this study was to evaluate the cross-talk among metabolism, stress response, immune system and reproduction in immature and mature females, coupling histological and transcriptomic approaches. The transcriptome of livers from 3 immature and 3 mature females was analyzed using the Artificial Intelligence RNA-Seq. For the histological analysis, ovary and liver samples were collected from 50 specimens caught during the reproductive season in the Mediterranean Sea. A total of 750 genes were differentially expressed between the livers. The gene ontologtabey analysis showed 91 upregulated and 161 downregulated biological process GO terms. Instead, the KEGG enrichment analysis revealed 15 enriched pathways. Furthermore, the binding occurring between estrogen receptors and aryl hydrocarbon receptor nuclear translocator, upregulated in mature females, could be liable for the inhibition of detoxification pathway. Indeed, at the histological level, mature females showed a higher density and number of melanomacrophage centers, biomarkers of stress. The present findings reveal the cross-talk among response to environmental stressors, metabolism and reproduction, highlighting that mature females invest a lot of energy in reproduction instead of immune response and detoxification.

show abstract

Opsins and gonadal circadian rhythm in the swordfish (Xiphias gladius) ovary: Their potential roles in puberty and reproductive seasonality

Cited by 5 publications

References 52 publications

Antagonistic interaction between caffeine and ketamine in zebrafish: Implications for aquatic toxicity

Antagonistic interaction between caffeine and ketamine in zebrafish: Implications for aquatic toxicity

Identifying Environmental Endocrine Disruptors Associated With the Age at Menarche by Integrating a Transcriptome-Wide Association Study With Chemical-Gene-Interaction Analysis

A Window of Vulnerability: Chronic Environmental Stress Does Not Impair Reproduction in the Swordfish Xiphias gladius

Contact Info

Product

Resources

About