Opposite Changes in the Serum Brain-Derived Neurotrophic Factor in Anorexia Nervosa and Obesity

Monteleone, Palmieroi; Tortorella, Alfonso; Martiadis, Vassilis; Serritella, Cristina; Fuschino, Antonio; Maj, Mario

doi:10.1097/01.psy.0000138119.12956.99

Cited by 103 publications

(88 citation statements)

References 29 publications

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“…Because the serum BDNF levels have been reported to change according to age, 31 body weight, BMI, 32 depression, 16,17 metabolic disorders, including diabetes mellitus, [19][20][21] and regular exercise, 33,34 we adjusted the model for these potential confounding factors. The association between the serum BDNF levels and dyssomnia remained statistically significant even after adjusting for these confounders.…”

Section: Discussionmentioning

confidence: 99%

Serum Brain-Derived Neurotrophic Factor Levels Are Associated with Dyssomnia in Females, but not Males, among Japanese Workers

Nishichi

Nufuji

Washio

et al. 2013

Journal of Clinical Sleep Medicine

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Study Objectives: Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that promote the growth and survival of neurons. Recent evidence suggests that BDNF is a sleep regulatory substance that contributes to sleep behavior. However, no studies have examined the association between the serum BDNF levels and dyssomnia. The present study was conducted to clarify the association between the serum BDNF levels and dyssomnia. Methods: A total of 344 workers (age: 40.1 ± 10.5 years, male: 204, female: 140) were included in the study. The serum BDNF levels were categorized into tertiles according to sex. Results: The prevalence of dyssomnia was 35.1% in males and 30.0% in females. In the females, the BDNF levels were found to be negatively associated with dyssomnia after adjusting for age, body mass index, hypertension, dyslipidemia, hyperglycemia, depression, smoking, alcohol intake, and regular exercise. Compared with the females in the high BDNF group, the multivariate odds ratio (95% CI) of dyssomnia was 2.08 (0.62-6.98) in females in the moderate BDNF group and 8.41 (2.05-27.14) in females in the low BDNF group. No such relationships were found in the males. Conclusions: The serum BDNF levels are associated with dyssomnia in Japanese female, but not male, workers. keywords: Serum brain-derived neurotrophic factor, dyssomnia, sex, Japanese worker Citation: Nishichi R; Nufuji Y; Washio M; Shuzo Kumagai S. Serum brain-derived neurotrophic factor levels are associated with dyssomnia in females, but not males, among Japanese workers. J Clin Sleep Med 2013;9(7):649-654.

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Section: Discussionmentioning

confidence: 99%

Serum Brain-Derived Neurotrophic Factor Levels Are Associated with Dyssomnia in Females, but not Males, among Japanese Workers

Nishichi

Nufuji

Washio

et al. 2013

Journal of Clinical Sleep Medicine

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“…In the study on Monteleone et al increased BDNF levels have been observed in the serum of obese women compared with those in healthy women. The level of BDNF has been positively correlated with BMI and weight [14]. Many studies show the correlation between Val homozygotes and greater BMI in comparison to Met carriers in both adults and children in many ethnicities [13,18,30,31].…”

Section: Brain-derived Neurotrophic Factor Val66met Polymorphism In Cmentioning

confidence: 99%

“…The methionine allele is also associated with a greater risk of developing eating disorders, such as bulimia nervosa and binge-eating [26]. Also decreased BDNF levels have been reported in women with anorexia nervosa [14]. Some studies prove the connection between BDNF depletion and greater BMI, by demonstrating lower food intake and greater energy expenditure after administrating exogenous BDNF into the brain [27][28][29].…”

Section: Brain-derived Neurotrophic Factor Val66met Polymorphism In Cmentioning

confidence: 99%

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Brain-Derived Neurotrophic Factor Val66Met Polymorphism in Contex of Executive Functions and Working Memory in Obese Patients

Bieliaski¹,

Lesiewska²,

Jaracz³

et al. 2018

Neuropsychiatry

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Neurothrophins are crucial in the regulation of many processes, such as nerve cells development and neuroplasticity and brain-derived neurothrophic factor (BDNF) is the major one. Researchers still scrutinize the role of BDNF Val66Met polymorphism in eating disorders and cognition, however, literature present inconsistent findings regarding this topic. Most of all, the exact mechanism of how exactly BDNF influences cognitive functioning in obesity is unknown. In our study, we try to elucidate the association of BDNF Val66Met polymorphism with executive functions and working memory on large obese population. 375 obese patients underwent biometric analyses and neuropsychological assessment. The Wisconsin Card Sorting Test (WCST) was used to assess cognitive functions. Genetic polymorphism in BDNF was evaluated in peripheral blood samples.Results indicated that both BDNF Val66Met polymorphism and gender showed significant correlations with BMI, WCST_P and WCST_CLR. Females showed higher BMI values than men,, however males scored higher in WSCT_P and WSCT_CLR. Val/Val carriers presented worse results of WCST and BMI. Kendall's partial rank correlation tests determined that both genotype and BMI showed significant correlations with WCST_CLR, WCST_CC and WCST_1st, in which BMI correlation was stronger. Analysis of mild and morbid obesity showed, that severe obese younger subjects presented worse WCST_P, WCST_NP, and WCST_CLR. Significant interaction effects for WCST parameters were found for gender, age, BMI and BDNF Val66Met. Importantly, in this study none Met/Met carriers were observed.The Val66Met BDNF polymorphism indirectly influenced the poorer cognitive functioning observed in the obese subpopulation with Val/Val genotype, rather than Val/Met genotype. A higher BMI was associated with the Val allele, suggesting that obesity may have deteriorated the activity of the prefrontal cortex. According to results, BDNF Val66Met polymorphism seems to contribute to greater obesity in our study. It is greater BMI, rather than genotype, which caused worse executive functioning and working memory. KeywordsVal66Met BDNF, Neurothrophins, Obesity Neuropsychiatry (London) (2018) 8(1) 112Research Maciej Bieliński the worse scores in WCST, and how BDNF Val66Met influences the severity of obesity. Materials and Methods ParticipantsA total of 375 adult Caucasian patients of Polish nationality were enrolled in this study, including 233 women and 142 men, after excluding secondary reasons of obesity. The mean age of all participants was 54 (range, 20-76) years old; the mean age for women was 52 (20-75) years old, and for men 56 (42-67) years old. The exclusion criteria were individuals with a severe somatic or psychiatric disorder included in the Diagnostic

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“…Human studies have shown that serum BDNF levels are increased in obese women and decreased in women with anorexia nervosa compared with healthy individuals (119). Epidemiological evidence suggests that polymorphisms in BDNF may affect weight; the Val66Met BDNF polymorphism is associated with a lower BMI in healthy subject compared with healthy individuals with alternate polymorphisms (64).…”

Section: Molecular Mechanisms Of Adaptive Responses To Oxidative Stressmentioning

confidence: 99%

Impaired Adaptive Cellular Responses to Oxidative Stress and the Pathogenesis of Alzheimer's Disease

Texel

Mattson

2011

Antioxidants & Redox Signaling

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As is generally true with other age-related diseases, Alzheimer's disease (AD) involves oxidative damage to cellular components in the affected tissue, in this case the brain. The causes and consequences of oxidative stress in neurons in AD are not fully understood, but considerable evidence points to important roles for accumulation of amyloid b-peptide upstream of oxidative stress and perturbed cellular Ca 2+ homeostasis and energy metabolism downstream of oxidative stress. The identification of mutations in the b-amyloid precursor protein and presenilin-1 as causes of some cases of early onset inherited AD, and the development of cell culture and animal models based on these mutations has greatly enhanced our understanding of the AD process, and has greatly expanded opportunities for preclinical testing of potential therapeutic interventions. In this regard, and of particular interest to us, is the elucidation of adaptive cellular stress response pathways (ACSRP) that can counteract multiple steps in the AD neurodegenerative cascades, thereby limiting oxidative damage and preserving cognitive function. ACSRP can be activated by factors ranging from exercise and dietary energy restriction, to drugs and phytochemicals. In this article we provide an overview of oxidative stress and AD, with a focus on ACSRP and their potential for preventing and treating AD. Antioxid. Redox Signal. 14, 1519-1534.

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Opposite Changes in the Serum Brain-Derived Neurotrophic Factor in Anorexia Nervosa and Obesity

Abstract: The BDNF changes observed in AN and obesity are likely secondary adaptive mechanisms aimed at counteracting the change in energy balance that occurs in these syndromes.

Cited by 103 publications

References 29 publications

Serum Brain-Derived Neurotrophic Factor Levels Are Associated with Dyssomnia in Females, but not Males, among Japanese Workers

Serum Brain-Derived Neurotrophic Factor Levels Are Associated with Dyssomnia in Females, but not Males, among Japanese Workers

Brain-Derived Neurotrophic Factor Val66Met Polymorphism in Contex of Executive Functions and Working Memory in Obese Patients

Impaired Adaptive Cellular Responses to Oxidative Stress and the Pathogenesis of Alzheimer's Disease

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