Joseph T. Neary, You-Fang Shi, Yuan Kang, Minh D. Tran
Extracellular nucleotides play important trophic roles in development and CNS injury but functions of distinct purinergic receptors and related signaling pathways have not been fully elucidated. Here we have identified opposing effects of P2X and P2Y receptors on the ability of FGF2 to induce proliferation in primary cultures of rat cortical astrocytes. Low concentrations of ATP enhanced DNA synthesis induced by FGF2 whereas high concentrations inhibited FGF2-induced proliferation. Comparison of concentration…
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