Opportunistic infections among individuals with HIV-1/AIDS in the highly active antiretroviral therapy era at a Quaternary Level Care Teaching Hospital

Galisteu, Katia Jaira; Cardoso, Luciana Ventura; Furini, Adriana Antônia da Cruz; Júnior, Arlindo Schiesari; Cesarino, Cláudia Bernardi; Franco, Célia Maria Landi; Baptista, Andréa Regina de Souza; Machado, Ricardo Luiz Dantas

doi:10.1590/0037-8682-0299-2014

Cited by 10 publications

(11 citation statements)

References 15 publications

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“…Despite the advances in controlling opportunistic diseases in patients with HIV/AIDS, especially after ART, the frequency and mortality related to these diseases remain high 13 . Galisteu et al 14 also revealed that opportunistic diseases are frequent and consider that the discovery of their existence is especially related to the lack of adherence to the treatment, which was correlated to low schooling level. Our results also show low schooling level and non-adherence to the ART, especially when related to the recent diagnosis and treatment abandonment.…”

Section: Discussionmentioning

confidence: 99%

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Déficits motores e preditores de perda de mobilidade ao final da internação em indivíduos com neurotoxoplasmose

et al. 2019

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RESUMO A neurotoxoplasmose (NTX) é uma das principais doenças oportunistas presentes em indivíduos portadores do vírus da imunodeficiência humana (HIV). A doença promove lesões cerebrais focais com efeito de massa que podem gerar uma variedade de sequelas capazes de comprometer a realização das atividades da vida diária, dentre elas, a deambulação. O objetivo deste estudo foi verificar os principais déficits motores apresentados e identificar os fatores de risco para a perda de mobilidade ao final da internação. Trata-se de um estudo observacional cuja amostra foi composta por dados de prontuários de indivíduos portadores do vírus HIV e diagnóstico de NTX. Foi realizada a revisão de prontuários eletrônicos e a classificação da mobilidade hospitalar, além da coleta de dados clínicos e epidemiológicos. Aplicou-se estatística descritiva e regressão logística binária. Foram avaliados 161 prontuários, com prevalência do sexo masculino e mediana de idade de 39 anos. Os déficits motores na admissão foram a ausência de deambulação (42,9%), hemiparesia (42,3%), paresia de membros inferiores (37,3%), déficit de equilíbrio (35,4%). Ao final da internação 32,9% não deambulavam. Os preditores para perda da mobilidade ao final da internação foram: utilização de ventilação mecânica invasiva (VMI), inclusão no programa de cuidados paliativos e não deambular na admissão. Os principais déficits motores foram a ausência de deambulação, a hemiparesia à direita e o déficit de equilíbrio.

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Section: Discussionmentioning

confidence: 99%

“…NTX was cited as the second most frequent opportunistic infection in HIV carriers, being directly related to the reduction of TCD4 lymphocytes. Moreover, having a viral load greater than 10,000 copies increases in 90% the chance of developing the disease 14 . We found low levels of TDC4 lymphocytes and high viral load in our study.…”

Section: Discussionmentioning

confidence: 99%

Déficits motores e preditores de perda de mobilidade ao final da internação em indivíduos com neurotoxoplasmose

et al. 2019

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“…The emergence of pandemic spread of AIDS constitute the greatest challenge to public health in modern time, with changing scenario of AIDS epidemic a host of opportunistic infections add to the present epidemic state of some existing infections like tuberculosis (Dabla et al, 2015). Opportunistic infections remain frequent in the ART era even in populations where access to medical care in considered satisfactory, these diseases can arises with any level of viral load and CD 4 + T cell count (Galisteu et al, 2015). Indian guidelines and western country guidelines have certain differences; wherever possible, that gap should be bridged.…”

Section: Introductionmentioning

confidence: 99%

Study of Opportunistic Infections in HIV Seropositive Patients in Tertiary Care Hospital, Maharashtra, India

Kolhe¹,

More²

2017

Int.J.Curr.Microbiol.App.Sci

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“…HIV infection is associated with a very high viral load in the body leading to a progressive depletion of immune cells, particularly CD4 + T cells [ 1 , 2 ]. The infection can be treated with highly active antiretroviral therapy (HAART) consisting of at least three drugs from at least two classes of antiretroviral agents [ 3 ]. However, HAART cannot eliminate latent HIV reservoirs in resting CD 4 + /CD 45 RO + T memory (Tm) cells [ 3 , 4 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…The infection can be treated with highly active antiretroviral therapy (HAART) consisting of at least three drugs from at least two classes of antiretroviral agents [ 3 ]. However, HAART cannot eliminate latent HIV reservoirs in resting CD 4 + /CD 45 RO + T memory (Tm) cells [ 3 , 4 , 6 ]. The best way to completely eliminate this reservoir is to reactivate latent HIV-1 by inducing proviral gene expression [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

PLGA-PEG Nanoparticles Coated with Anti-CD45RO and Loaded with HDAC Plus Protease Inhibitors Activate Latent HIV and Inhibit Viral Spread

et al. 2015

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Activating HIV-1 proviruses in latent reservoirs combined with inhibiting viral spread might be an effective anti-HIV therapeutic strategy. Active specific delivery of therapeutic drugs into cells harboring latent HIV, without the use of viral vectors, is a critical challenge to this objective. In this study, nanoparticles of poly(lactic-co-glycolic acid)-polyethylene glycol diblock copolymers conjugated with anti-CD45RO antibody and loaded with the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) and/or protease inhibitor nelfinavir (Nel) were tested for activity against latent virus in vitro. Nanoparticles loaded with SAHA, Nel, and SAHA + Nel were characterized in terms of size, surface morphology, zeta potential, entrapment efficiency, drug release, and toxicity to ACH-2 cells. We show that SAHA- and SAHA + Nel-loaded nanoparticles can target latently infected CD4+ T-cells and stimulate virus production. Moreover, nanoparticles loaded with SAHA + NEL were capable of both activating latent virus and inhibiting viral spread. Taken together, these data demonstrate the potential of this novel reagent for targeting and eliminating latent HIV reservoirs.

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Opportunistic infections among individuals with HIV-1/AIDS in the highly active antiretroviral therapy era at a Quaternary Level Care Teaching Hospital

Cited by 10 publications

References 15 publications

Déficits motores e preditores de perda de mobilidade ao final da internação em indivíduos com neurotoxoplasmose

Déficits motores e preditores de perda de mobilidade ao final da internação em indivíduos com neurotoxoplasmose

Study of Opportunistic Infections in HIV Seropositive Patients in Tertiary Care Hospital, Maharashtra, India

PLGA-PEG Nanoparticles Coated with Anti-CD45RO and Loaded with HDAC Plus Protease Inhibitors Activate Latent HIV and Inhibit Viral Spread

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